PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ywhae Ppp2r2a 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2r2a Eed 24457600 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ksr1 Ppp2r2a 12932319 innatedb exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxl16 Ppp2r2a 24390425 biogrid exp, ortho P Ppp2cb Ppp2r2a 24390425 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2r2a Ppp2r1a 16857963 intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2r2a Mlh1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct6a Ppp2r2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2r2a Dapk1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Arhgef2 Ppp2r2a ortho GP G G G G G G G G G G G G G G G G G G G G G Dsp Ppp2r2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G Ndrg1 Ppp2r2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct5 Ppp2r2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2r2a Lats2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2r2a Rps6kb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ntrk1 Ppp2r2a ortho Ppp2r2a Ppme1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Egfr Ppp2r2a ortho GP G G G G G G G G G G G G G G G G G Rps28 Ppp2r2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gc Ppp2r2a ortho GP G G G G G G G G G G Ppp2r2a Ppp2r2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct8 Ppp2r2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2r2a Ankle2 ortho P Ppp2r2a Ecsit ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tgfbr1 Ppp2r2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2r2a Rbm7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2r2a BC055107 ortho Fabp5 Ppp2r2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2r2a Sik2 ortho Cct7 Ppp2r2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2r2a Strn3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2r2a Ppp2r2d ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ptpn14 Ppp2r2a ortho G Ppp2r2a Rps6kb2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Ier2 Ppp2r2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct2 Ppp2r2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2r2a Ncapd3 ortho P Ppp2r2a Chek2 ortho G G G G G G G G G G G G G G G G G G G G Ppp2r2a Cdk17 ortho P Foxc1 Ppp2r2a ortho G G G G G G G G Jun Ppp2r2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rrn3 Ppp2r2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct4 Ppp2r2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Notch1 Ppp2r2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2r2a Skiv2l2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cftr Ppp2r2a ortho G G G G G G G G Cacna1s Ppp2r2a ortho G G G G G G Abce1 Ppp2r2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspa4l Ppp2r2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2r2a Hdac5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2r2a Wdr4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Sertad4 Ppp2r2a ortho Cdk16 Ppp2r2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tcp1 Ppp2r2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2r2a Ppp2r1b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2r2a Cul3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2r2a Smurf1 ortho Ppp2r2a Tceal1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2r2a Fam122a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Grin2d Ppp2r2a ortho G Ppp2r2a Yars ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smad1 Ppp2r2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2r2a Grk5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct3 Ppp2r2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2r2a Xpo1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2r2a Rab11fip5 ortho G G G G G G G G G G G G G G G G G G G G G G G G Ppp3ca Ppp2r2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tuba4a Ppp2r2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Grin1 Ppp2r2a ortho G G G G G G G G Eif4ebp1 Ppp2r2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Grb2 Ppp2r2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2r2a Nrd1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mea1 Ppp2r2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2ca Ppp2r2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2r2a Ahi1 ortho G G G G G G G G G G G G G G G G G G Ppp2r2a Cdca4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2r2a Raf1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2r2a Thumpd1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Foxc2 Ppp2r2a ortho G G Elavl1 Ppp2r2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tp53 Ppp2r2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2r2a Mtor ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Ppp2r2a Eed MI:0004(affinity chromatography technology) 24457600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_332589 prey bait

PPI - HINT Gene A Gene B PMID Method Quality YWHAE PPP2R2A 16615898 0027 LC PPP2R2A PPP2R1A 16857963 0091 LC FBXL16 PPP2R2A 24390425 0004 LC PPP2CB PPP2R2A 24390425 0004 LC PPP2R2A EED 24457600 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q6P1F6 P62259 PPP2R2A YWHAE 0.081 16615898 Q76MZ3 Q6P1F6 PPP2R1A PPP2R2A 0.21 16857963 Q6P1F6 P30153 PPP2R2A PPP2R1A 0.236 26496610 Q96E09 Q6P1F6 FAM122A PPP2R2A 0.236 26496610 Q921E6 Q6P1F6 EED PPP2R2A 0.126 24457600 Q6P1F6 P62715 PPP2R2A PPP2CB 0.21 24390425 Q6P1F6 A2RT62 PPP2R2A FBXL16 0.376 24390425