PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Per2 Fbxl3 23452856,23452855 intact exp G G G G G G G G G G G G G G G G G G G G G G Fbxl3 Skp1 23503662,23452855 biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cry1 Fbxl3 23452856,23452855,17462724 biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxl3 Cul1 23452855 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxl3 Cry2 23452856,23503662,23452855,17462724 biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cand1 Fbxl3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btg1 Fbxl3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d2 Fbxl3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hsp90aa1 Fbxl3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxl3 Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rfx1 Fbxl3 ortho G G G G G G Hsp90ab1 Fbxl3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rfx2 Fbxl3 ortho G G G Btg2 Fbxl3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9R194 Q8C4V4 affinity chromatography technology 17462724 physical association X 2 Q9R194 Q8C4V4 affinity chromatography technology 23503662 physical association X 2 P97784 Q8C4V4 affinity chromatography technology 17462724 physical association X 2 Q8C4V4 Q9WTX5 affinity chromatography technology 23503662 physical association X 2 Q8C4V4 bimolecular fluorescence complementation 23452855 physical association C 3 Q8C4V4 anti tag coimmunoprecipitation 23452856 physical association C 3 Q8C4V4 anti tag coimmunoprecipitation 23452856 association C 4 A0A090N7U0 Q8C4V4 bimolecular fluorescence complementation 23452855 physical association X 2 Q9R194 Q8C4V4 anti tag coimmunoprecipitation 17462724 physical association X 2 Q9R194 Q8C4V4 anti tag coimmunoprecipitation 17462724 physical association X 2 Q9R194 Q8C4V4 anti tag coimmunoprecipitation 23452855 physical association X 2 Q9R194 Q8C4V4 anti tag coimmunoprecipitation 23452856 physical association X 2 P97784 Q8C4V4 anti tag coimmunoprecipitation 17462724 physical association X 2 P97784 Q8C4V4 anti tag coimmunoprecipitation 17462724 physical association X 2 P97784 Q8C4V4 anti tag coimmunoprecipitation 23452855 physical association X 2 P97784 Q8C4V4 bimolecular fluorescence complementation 23452855 physical association X 2 P97784 Q8C4V4 anti tag coimmunoprecipitation 23452855 physical association X 2 P97784 Q8C4V4 anti tag coimmunoprecipitation 23452856 physical association X 2 P97784 Q8C4V4 anti tag coimmunoprecipitation 23452856 physical association X 2 P63208 Q8C4V4 bimolecular fluorescence complementation 23452855 physical association X 2 Q8C4V4 anti tag coimmunoprecipitation 23452855 association C 4 Q8C4V4 anti tag coimmunoprecipitation 17462724 association C 3 Q8C4V4 anti tag coimmunoprecipitation 23452856 association C 4 Q8C4V4 O54943 anti tag coimmunoprecipitation 23452855 physical association X 2 Q8C4V4 O54943 anti tag coimmunoprecipitation 23452856 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Cry1 Fbxl3 MI:0809(bimolecular fluorescence complementation)|MI:0809(bimolecular fluorescence complementation)|MI:0007(anti tag coimmunoprecipitation)|MI:0809(bimolecular fluorescence complementation)|MI:0809(bimolecular fluorescence complementation)|MI:0809(bimolecular fluorescence complementation)|MI:0809(bimolecular fluorescence complementation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0809(bimolecular fluorescence complementation) 17462724,23452855 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(biogrid)|(intact)|(intact) UniProt_127756|UniProt_177029|UniProt_166403|UniProt_177026|UniProt_127759|UniProt_177020|UniProt_177021|UniProt_166408|BIOGRID_321802|UniProt_166405|UniProt_177032 neutral component|neutral component|prey|prey|neutral component|prey|prey|bait|prey|prey|neutral component neutral component|neutral component|bait|bait|neutral component|bait|bait|prey|bait|bait|neutral component Per2 Fbxl3 MI:0809(bimolecular fluorescence complementation) 23452855 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_177023 prey bait Fbxl3 Skp1 MI:0809(bimolecular fluorescence complementation)|MI:0114(x-ray crystallography) 23452855,23503662 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_177026|BIOGRID_328873 bait|bait prey|prey Fbxl3 Cry2 MI:0114(x-ray crystallography)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0809(bimolecular fluorescence complementation)|MI:0007(anti tag coimmunoprecipitation) 17462724,23452855,23503662 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association) (biogrid)|(intact)|(biogrid)|(intact)|(intact)|(intact) BIOGRID_328872|UniProt_166407|BIOGRID_321803|UniProt_166406|UniProt_177025|UniProt_166403 bait|prey|bait|bait|bait|bait prey|bait|prey|prey|prey|prey

PPI - HINT Gene A Gene B PMID Method Quality CRY1 FBXL3 23452855,23452855 0007,0809 LC PER2 FBXL3 23452855,23452856 0007,0007 LC CRY1 FBXL3 23452855,23452855,23452856,17462724,17462724 0007,0809,0007,0004,0007 LC FBXL3 CRY2 23452856,23452855,23503662,17462724,17462724 0007,0007,0004,0004,0007 LC FBXL3 SKP1 23452855,23503662 0007,0004 LC FBXL3 CUL1 23452855 0007 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8C4V4 O54943 FBXL3 PER2 0.376 23452855,23452856 Q9WTX6 Q8C4V4 CUL1 FBXL3 0.21 23452855 Q9R194 Q8C4V4 CRY2 FBXL3 0.848 23452855,23452856,17462724,23503662 Q8C4V4 P63208 FBXL3 SKP1 0.376 23452855,23452856 Q9WTX5 Q8C4V4 SKP1 FBXL3 0.376 23452855,23503662 Q8C4V4 P97784 FBXL3 CRY1 0.941 17462724,23452855,23452856 Q8C4V4 Q13616 FBXL3 CUL1 0.376 23452855,23452856