PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Cryab Fbxo4 17081987 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G Ywhae Fbxo4 21242966 intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G Ccnd1 Fbxo4 17081987 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G Fbxo4 Skp1 17081987 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G Cdc34 Fbxo4 ortho G G G G G G G G G G G G G G G G G G G G G G G G Hsp90aa1 Fbxo4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G Terf1 Fbxo4 ortho G G G G G G G G G G G G G G G G G G G G G G G Fbxo4 Elf4 ortho G G G G G Fbxw8 Fbxo4 ortho G G G G G G G G G G G G G G G G G G G G G G G G Hsp90ab1 Fbxo4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G Fbxo4 Cul1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G Ube2d2 Fbxo4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G Tp53 Fbxo4 ortho G G G G G G G G G G G G G G G G G G G G G G Nedd8 Fbxo4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G Fbxo4 Fbxo4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G Elavl1 Fbxo4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8CHQ0 P25322 affinity chromatography technology 17081987 physical association X 2 Q8CHQ0 Q9WTX5 affinity chromatography technology 17081987 physical association X 2 P23927 Q8CHQ0 affinity chromatography technology 17081987 physical association X 2 Q8CHQ0 P62259 anti bait coimmunoprecipitation 21242966 physical association X 2 Q8CHQ0 P62259 anti bait coimmunoprecipitation 21242966 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Ywhae Fbxo4 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 21242966 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_173017|UniProt_173016 prey|bait bait|prey Fbxo4 Skp1 MI:0004(affinity chromatography technology) 17081987 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_319775 bait prey Cryab Fbxo4 MI:0004(affinity chromatography technology) 17081987 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_319773 prey bait Ccnd1 Fbxo4 MI:0004(affinity chromatography technology) 17081987 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_319774 prey bait

PPI - HINT Gene A Gene B PMID Method Quality CRYAB FBXO4 17081987 0004 LC CCND1 FBXO4 17081987 0004 LC YWHAE FBXO4 21242966 0006 LC FBXO4 RAB40B 26885862 0676 LC FBXO4 SKP1 17081987 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8CHQ0 P23927 FBXO4 CRYAB 0.21 17081987 Q8CHQ0 P25322 FBXO4 CCND1 0.21 17081987 Q9WTX5 Q8CHQ0 SKP1 FBXO4 0.21 17081987 Q8VHP8 Q8CHQ0 RAB40B FBXO4 0.126 26885862