PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ppara Ncoa6 10681503 biogrid exp G G G G G G G G G G G G G G Men1 Ppara 22001208 mint,intact exp G G G G G G G G G G G G G G Ppara Gata3 11724781 biogrid exp G G G Ppara Pcmt1 15150259 biogrid exp G G G G G G G G G G G G G G Ppara Gata4 11724781 biogrid exp G G G G G G G G Gata1 Ppara 11724781 biogrid exp G Ppara Gata6 11724781 biogrid exp G G G G G G G G G G G G Ppara Stat6 21149710 dip exp G G G G G G G G G G G G G G Fabp1 Ppara 11226238 biogrid exp, ortho G G G G G G G Ppara Rxra 20211142 biogrid exp, ortho G G G G G G G G G G G G G G Ppara Sirt1 19356714 intact exp, ortho G G G G G G G G G G G G G G Ppargc1a Ppara 20392859 innatedb exp, ortho G G G G G G G G G G G G G Ppara Lpin1 20392859 innatedb exp, ortho G G G G G G G G G G G G G G Ppara Nrip1 ortho G G G G G G G G G G G G G G Ppara E2f4 ortho G G G G G G G G G G G G G G Ppara Prmt1 ortho G G G G G G G G G G G G G G Nr3c1 Ppara ortho G G G G G G G G G G G G G G Gadd45b Ppara ortho G G G G G G G G G G G G G Rb1 Ppara ortho G G G G G G G G G G G G G G Ppara Prmt8 ortho Protein Brd1 Ppara ortho G G G G G G G G G G G G G G Ppara Prkcd ortho G G G G G G G G G G G G G G Ppara Mecr ortho G G G G G G G G G G G G G G Helz2 Ppara ortho G G G G G G G G G G G G G G Protein Akap13 Ppara ortho Hdac3 Ppara ortho G G G G G G G G G G G G G G Aip Ppara ortho G G G G G G G G G G G G G G Ppara Dutp ortho G G G G G G G G G G G G G G Ppara Pou1f1 ortho Ppara Stat5b ortho G G G G G G G G G G G G G G Ppara Gadd45a ortho G G G G G G G G G G G G G G Ppara Gadd45g ortho G G G G G G G G G G G G G G Ppara Med24 ortho G G G G G G G G G G G G G G Ppara Stac3 ortho Ppara Ppara ortho G G G G G G G G G G G G G G Ppara Ncor1 ortho G G G G G G G G G G G G G G Ppara Chd9 ortho Ppara Ube2i ortho G G G G G G G G G G G G G G Ppara Mapk1 ortho G G G G G G G G G G G G G G Ep300 Ppara ortho Ppara Rxrg ortho G G G G G Ppara Mapk3 ortho G G G G G G G G G G G G G G Ppara Med1 ortho G G G G G G G G G G G G G G Ppara Rbl1 ortho G G G G G G G G G G G G G Ppara Grb2 ortho G G G G G G G G G G G G G G Ppara Ncoa2 ortho G G Fasn Ppara ortho G G G G G G G G G G G G G G Ppara Ppard ortho Ubc Ppara ortho G G G G G G G G G G G G G G Ppara Ppargc1b ortho G G G G G G G G G G G G G G Ppara E2f1 ortho G Ppara Nrbf2 ortho G G G G G G G G G G G G G G Hsp90aa1 Ppara ortho G G G G G G G G G G G G G G Ppara Dr1 ortho G G G G G G G G G G G G G G Ppara Rxrb ortho G G G G G G G G G G G G G G Ppara Creb1 ortho G G G G G G G G G G Ppara Pik3r3 ortho Ppara Ncor2 ortho G G G G G G G G G G G G G G Ppara Lamtor5 ortho G G G G G G G G G G G G G G Ppara Dap3 ortho G G G G G G G G G G G G G G Ppara Foxa3 ortho G G G G G G Ppara Ncoa1 ortho G G G G G G G G G G G G G G Lpl Ppara ortho G G G G G G G G G G G G G G Ppara Nr1h3 ortho G G G G G G G G G G G G G Prkca Ppara ortho G G G G G G G G G G Ncoa3 Ppara ortho G G G G G G G G G G G Ppara Mdm2 ortho G G G G G G G G G G G G G G Protein Cep350 Ppara ortho G G G G G G G G G G G G G G Ppara Rela ortho G G G G G G G G G G G G G G Ppara Prmt2 ortho G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P41182 P23204 affinity chromatography technology 12970571 physical association X 2 P23204 O75376-2 two hybrid 11903058 direct interaction X 2 P23204 P12710 pull down 11226238 direct interaction X 2 P23204 Q9BV79 two hybrid 9795230 direct interaction X 2 P23204 F1D8N1 two hybrid 8621574 direct interaction X 2 P23204 P17678 pull down 11724781 direct interaction X 2 P23204 P17679 pull down 11724781 direct interaction X 2 Q61169 P23204 pull down 11724781 direct interaction X 2 P28700 P23204 two hybrid 20211142 direct interaction X 2 P23772 P23204 pull down 11724781 direct interaction X 2 P23204 affinity chromatography technology 15150259 physical association X 2 P23204 Q5XJV5 pull down 10681503 direct interaction X 2 P23204 A5JUZ3 affinity chromatography technology 10872826 physical association X 2 P23204 P70583 pull down 8910358 direct interaction X 2 P23204 P23824 pull down 11724781 direct interaction X 2 P23204 P23825 pull down 11724781 direct interaction X 2 P23204 Q08369 pull down 11724781 direct interaction X 2 A0A024QZI5 P23204 coimmunoprecipitation 10347167 physical association X 2 P23204 P52633 anti bait coimmunoprecipitation 21149710 physical association X 2 P23204 Q53Z05 anti bait coimmunoprecipitation 19356714 physical association X 2 P23204 O88559 anti tag coimmunoprecipitation 22001208 physical association X 2 P23204 O88559 anti tag coimmunoprecipitation 22001208 physical association X 2 P23204 Q12802 pull down 9627117 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Men1 Ppara MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 22001208 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_175811|UniProt_175810 prey|bait bait|prey Ppara Sirt1 MI:0006(anti bait coimmunoprecipitation) 19356714 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_167992 bait prey Fabp1 Ppara MI:0018(two hybrid) 11226238 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_311541 bait prey Gata1 Ppara MI:0096(pull down) 11724781 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_318839 prey bait Ppara Gata6 MI:0096(pull down) 11724781 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_318838 bait prey Ppara Gata4 MI:0096(pull down) 11724781 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_318837 bait prey Ppara Rxra MI:0018(two hybrid) 20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_313515 bait prey Ppara Pcmt1 MI:0004(affinity chromatography technology) 15150259 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_315300 prey bait Ppara Gata3 MI:0096(pull down) 11724781 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_318836 bait prey

PPI - HINT Gene A Gene B PMID Method Quality PPARA RXRA 20211142 0018 HT PPARGC1A PPARA 20392859 0007 LC MEN1 PPARA 22001208 0007 LC FABP1 PPARA 11226238 0096 LC GATA1 PPARA 11724781 0096 LC PPARA PCMT1 15150259 0004 LC PPARA GATA3 11724781 0096 LC PPARA STAT6 21149710 0006 LC PPARA GATA4 11724781 0096 LC PPARA GATA6 11724781 0096 LC PPARA SIRT1 19356714 0006 LC PPARA NCOA6 10681503 0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P23204 O75376 PPARA NCOR1 0.309 11903058 P23204 P17678 PPARA GATA1 0.309 11724781 P23204 P17679 PPARA GATA1 0.309 11724781 P23772 P23204 GATA3 PPARA 0.309 11724781 P23824 P23204 GATA2 PPARA 0.309 11724781 P23825 P23204 GATA3 PPARA 0.309 11724781 P28700 P23204 RXRA PPARA 0.183 20211142 Q08369 P23204 GATA4 PPARA 0.309 11724781 Q13133 P23204 NR1H3 PPARA 0.309 8621574 Q61169 P23204 GATA6 PPARA 0.309 11724781 P24522 P23204 GADD45A PPARA 0.21 10872826 P23204 O88559 PPARA MEN1 0.21 22001208 P23204 P12710 PPARA FABP1 0.309 11226238 Q9BV79 P23204 MECR PPARA 0.309 9795230 P70583 P23204 DUT PPARA 0.309 8910358 P41182 P23204 BCL6 PPARA 0.21 12970571 Q13772 P23204 NCOA4 PPARA 0.033 10347167