PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Mgrn1 Mgrn1 12560552 biogrid exp Tsg101 Mgrn1 19703557 biogrid exp, ortho Mgrn1 Fbxo6 ortho Ube2t Mgrn1 ortho Ube2d2 Mgrn1 ortho Itch Mgrn1 ortho Ptprk Mgrn1 ortho Mgrn1 Apbb1 ortho Ube2e1 Mgrn1 ortho Ube2j2 Mgrn1 ortho Mc4r Mgrn1 ortho Atp1b4 Mgrn1 ortho Ube2w Mgrn1 ortho Ube2d2b Mgrn1 ortho Mc1r Mgrn1 ortho Elavl1 Mgrn1 ortho Htt Mgrn1 ortho Ube2g2 Mgrn1 ortho Hspa4 Mgrn1 ortho Mc2r Mgrn1 ortho Slc2a4 Mgrn1 ortho Ube2i Mgrn1 ortho Ubc Mgrn1 ortho Atxn3 Mgrn1 ortho Ube2d1 Mgrn1 ortho Mgrn1 Mrap ortho Tafazzin, WW domain-containing transcription regulator protein 1 Mgrn1 ortho Ube2d3 Mgrn1 ortho Ube2q2 Mgrn1 ortho Tuba4a Mgrn1 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9D074 Q9D074 enzymatic study 12560552 direct interaction X 2 Q9D074 Q61187 two hybrid 19703557 direct interaction X 2 Q9D074 Q61187 affinity chromatography technology 19703557 physical association X 2 Q9D074 Q61187 affinity chromatography technology 19703557 physical association X 2 P04273 Q9D074 affinity technology 19524515 physical association X 2 P04273 Q9D074 pull down 19524515 physical association X 2 P04273 Q9D074 pull down 19524515 physical association X 2 P04273 Q9D074 fluorescence microscopy 19524515 colocalization X 2 P04273 Q9D074 affinity technology 19524515 physical association X 2 P04273 Q9D074 affinity technology 19524515 physical association X 2 P04273 Q9D074 affinity technology 19524515 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality TSG101 MGRN1 19703557,19703557 0018,0004 LC MGRN1 MGRN1 12560552 0415 LC TSG101 MGRN1 19703557,19703557 0018,0004 LC MGRN1 AMFR 26743086 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9D074 Q61187 MGRN1 TSG101 0.569 19703557 Q9D074 P04273 MGRN1 PRNP 0.702 19524515 Q9D074 Q9D074 MGRN1 MGRN1 0.332 12560552 Q9R049 Q9D074 AMFR MGRN1 0.376 26743086