PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Mylk Yaf2 15102471 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Yaf2 Rnf2 17296600 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kdm2b Yaf2 17296600 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Yaf2 Skp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rad54l Yaf2 ortho G G G G G G G G G G Yaf2 Cul1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q99LW6 enzymatic study 25260751 direct interaction X 2 Q99LW6 Q9CQJ4 affinity chromatography technology 17296600 physical association X 2 Q99LW6 Q9CQJ4 affinity chromatography technology 17296600 physical association X 2 Q99LW6 Q6P1G2-4 affinity chromatography technology 17296600 physical association X 2 Q99LW6 Q6P1G2-4 affinity chromatography technology 17296600 physical association X 2 Q99LW6 pull down 17296600 association C 10 Q99LW6 pull down 17296600 association C 52 Q99LW6 Q6PDN3 two hybrid 15102471 physical association X 2 Q99LW6 pull down 17296600 association C 11

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Yaf2 Rnf2 MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17296600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(biogrid)|(biogrid) UniProt_166512|UniProt_166511|BIOGRID_315712|BIOGRID_315734 prey|prey|prey|prey bait|prey|bait|bait Kdm2b Yaf2 MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17296600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid) UniProt_166520|BIOGRID_315758|BIOGRID_315754 bait|bait|bait prey|prey|prey Mylk Yaf2 MI:0018(two hybrid) 15102471 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_163135 bait prey

PPI - HINT Gene A Gene B PMID Method Quality MYLK YAF2 15102471 0018 LC KDM2B YAF2 17296600,17296600 0096,0004 LC YAF2 RNF2 17296600,17296600 0096,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9CQJ4 Q99LW6 RNF2 YAF2 0.236 17296600 Q99LW6 Q6P1G2 YAF2 KDM2B 0.236 17296600 Q99LW6 Q6PDN3 YAF2 MYLK 0.183 15102471