PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus March5 Mfn2 23727017 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G March5 Unk 25737280 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G March5 Mfn1 23727017 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G March5 Aktip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2n March5 ortho P Ube2d2 March5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc March5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G March5 Fis1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G March5 Denr ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Utrn March5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2e1 March5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d3 March5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sod1 March5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G March5 Ube2t ortho P G G G G G G G G G G G G March5 Ube2w ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G March5 Ecm29 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G March5 Park2 ortho G G G G March5 March5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Traf6 March5 ortho G G G G G G G G G G G G G G G G G G G G Map1b March5 ortho GP G G G G G G G G G G G G G G G G G G March5 Mavs ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G March5 Gramd3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2e3 March5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G March5 Mia3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2i March5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G March5 Dnm1l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d1 March5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tank March5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G March5 Creb3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B March5 Mfn2 MI:0004(affinity chromatography technology) 23727017 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_329816 bait prey March5 Mfn1 MI:0004(affinity chromatography technology) 23727017 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_329817 bait prey

PPI - HINT Gene A Gene B PMID Method Quality MARCH5 MFN2 23727017 0004 LC MARCH5 MFN1 23727017 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8BL48 Q3KNM2 UNK MARCH5 0.126 25737280 Q3KNM2 P46821 MARCH5 MAP1B 0.21 22308378 Q80U63 Q3KNM2 MFN2 MARCH5 0.21 23727017 Q811U4 Q3KNM2 MFN1 MARCH5 0.21 23727017