PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Birc6 Pgls 16615898 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc6 Eed 24457600 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc6 Ywhae 16615898 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc6 Rnf41 19527720 biogrid,mint,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc6 Unk 25737280 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc6 Birc6 15200957 innatedb,i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc6 Llgl2 ortho G G G G G G G G G G G G G G G G G G G G G G G Birc6 Fyn ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc6 Map2k1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc6 Figf ortho G G G G G G G G G G G G Birc6 Csnk2a1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Exoc4 Birc6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc6 Cdk1 ortho G G G G G G G G G G G G G G G G G G G G G Birc6 Eps15l1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Birc6 Casp9 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Clec11a Birc6 ortho G G G G G G G G G G G G G G G Birc6 Tex35 ortho Birc6 Herc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc6 Dfna5 ortho G G G G G G G G G G G G G G Ca11 Birc6 ortho G G G G G G G G G G G G G G G Birc6 Grb10 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc6 Gnb2l1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc6 Ube2d1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc5 Birc6 ortho G G G G G G G G G G G G G G Birc6 Fam58b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc6 Tbc1d22a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc6 Casp8 ortho G G G G G G G G G G G G G G G G G G G G G G G G Birc6 Wdr4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Birc6 Chia ortho G G G G G G G Birc6 Tp53 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc6 Casp3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc6 Diablo ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc6 Xiap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc6 Anapc11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc6 Rpgr ortho G G G G G G G G G G G G G G G G Birc6 Plk1 ortho G G G G G G G G G G G G G G Birc6 Golga4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kif23 Birc6 ortho G G G G G G G G G G G G G G Aurkb Birc6 ortho G G G G G G G G G G G G G Birc6 Vcl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc6 Ubc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc6 Uncharacterized protein C3orf20 homolog ortho Birc6 Klhl10 ortho G Birc6 Casp7 ortho G G G G G G G G G G G G G G G G G G G G G G G G Birc6 Exoc3 ortho Birc6 Cnot7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc6 Usp8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc6 Vav2 ortho G Birc6 Mos ortho Protein Myh13 Birc6 ortho Cdc27 Birc6 ortho G G G G G G Birc6 Htra2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc6 Rtbdn ortho G G G Birc6 Ncam1 ortho G G G G G G G G G G G G G G G G G Birc6 Fam175b ortho Birc6 Prss45 ortho Birc6 Rassf2 ortho G G G G G G G G G G G G G G G G Birc6 Mcph1 ortho Birc6 Rab8a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc6 Ccna2 ortho G G G G G G G G G G G G G G G G G G G G Birc6 Kif22 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc6 Golgi-specific brefeldin A-resistance factor 1, Prostaglandin E synthase 2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc6 Sirt7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O88738 O88738 coimmunoprecipitation 15200957 association Y 1 O88738 cosedimentation 16615898 colocalization C 1216 O88738 anti tag coimmunoprecipitation 18329369 association C 3 O88738 affinity chromatography technology 16512683 association C 138 P06493 O88738 anti tag coimmunoprecipitation 18329369 physical association X 2 O88738 E7CU85 anti tag coimmunoprecipitation 18329369 physical association X 2 O88738 Q8BH75 anti bait coimmunoprecipitation 19527720 association X 2 O88738 anti tag coimmunoprecipitation 18329369 association C 3

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Birc6 Rnf41 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19527720 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0914(association)|MI:0915(physical association) (intact)|MI:0471(mint)|(biogrid) UniProt_171005|MINT_71624|BIOGRID_315985 prey|prey|prey bait|bait|bait Birc6 Eed MI:0004(affinity chromatography technology) 24457600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_332474 prey bait

PPI - HINT Gene A Gene B PMID Method Quality BIRC6 BIRC6 15200957 0019 LC BIRC6 YWHAE 16615898 0027 LC BIRC6 PGLS 16615898 0027 LC BIRC6 RNF41 19527720,19527720 0004,0006 LC BIRC6 EED 24457600 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P62259 O88738 YWHAE BIRC6 0.081 16615898 O88738 O15392 BIRC6 BIRC5 0.21 18329369 O88738 O60645 BIRC6 EXOC3 0.21 18329369 P06493 O88738 CDK1 BIRC6 0.21 18329369 P53350 O88738 PLK1 BIRC6 0.21 18329369 Q02750 O88738 MAP2K1 BIRC6 0.21 18329369 Q96A65 O88738 EXOC4 BIRC6 0.21 18329369 Q8BL48 O88738 UNK BIRC6 0.126 25737280 Q8BH75 O88738 RNF41 BIRC6 0.376 19527720 P62158 O88738 CALM3 BIRC6 0.236 16512683 Q921E6 O88738 EED BIRC6 0.126 24457600 Q9CQ60 O88738 PGLS BIRC6 0.081 16615898