PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Strn Ywhaz 16959763 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Ywhae 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Mob4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Ddx1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Fgfr1op2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Esr1 ortho G G G G G Strn Dync1h1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Pcolce2 ortho G G G G G G G G G G G G G G G Strn Stk4 ortho P G G G G G G G Strn Schip1 ortho Strn Sike1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Sf3b5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cttnbp2 Strn ortho Strn Ect2 ortho G G G G G G G G G G G G Strn Bag2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Elavl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Slc43a3 Strn ortho G G G G G G G G G G G G G G G G G G G G G G G G Strn Cct6a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Ahnak Strn ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Cct4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Stk25 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Ntrk1 ortho Strn Lypd3 ortho G G G Strn Pgam5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Atf7ip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Lnx1 ortho G G G G G G G G G G G G G G G G G G G G Strn Hspb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Stk26 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Tnks2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Map4k4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Cct6b ortho P G Strn Slmap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Eif2s1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Cav1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Rassf3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Ppp2r1a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnai1 Strn ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Strn4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Cct2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Strip1 ortho P Strn Cct8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Tfip11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Ppp2cb ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Tcp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Dynll1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Traf3ip3 ortho Strn Mcc ortho Strn Cct5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Eef1e1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Tjp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Cct7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Ppp2r2c ortho P Strn Pdcd10 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Cpsf6 ortho P Strn Cct3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Ppp2r1b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Strip2 ortho Strn Wnk1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Apc ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Cttnbp2nl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Zranb1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Stk3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Stk24 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Rint1 ortho P Strn Strn3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Strn Nr1h3 ortho G G G G G G G G G G G G G G G G G G G G G Strn Brca1 ortho G G G G G G G G G G G G Strn Ppp2ca ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O55106 P63101 affinity chromatography technology 16959763 physical association X 2 B4DJ51 O55106 affinity chromatography technology 16512683 physical association X 2 O55106 cosedimentation 16615898 colocalization C 1216 O55106 proximity-dependent biotin identification 24255178 colocalization C 11 O55106 anti tag coimmunoprecipitation 18782753 physical association C 30 O55106 proximity-dependent biotin identification 24255178 colocalization C 10 Q9H2K2 O55106 anti tag coimmunoprecipitation 22153077 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Strn Ywhaz MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0004(affinity chromatography technology) 16615898,16959763 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(biogrid) UniProt_167131|UniProt_167130|UniProt_167132|UniProt_167134|UniProt_167115|UniProt_167135|UniProt_167116|UniProt_167114|BIOGRID_327464 neutral component|neutral component|neutral component|neutral component|neutral component|neutral component|neutral component|neutral component|prey neutral component|neutral component|neutral component|neutral component|neutral component|neutral component|neutral component|neutral component|bait

PPI - HINT Gene A Gene B PMID Method Quality STRN YWHAE 16615898 0027 LC STRN YWHAZ 16959763 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P62158 O55106 CALM3 STRN 0.126 16512683 P62259 O55106 YWHAE STRN 0.081 16615898 O55106 O00506 STRN STK25 0.126 18782753 P17987 O55106 TCP1 STRN 0.126 18782753 P30154 O55106 PPP2R1B STRN 0.126 18782753 P40227 O55106 CCT6A STRN 0.126 18782753 P48643 O55106 CCT5 STRN 0.126 18782753 P49368 O55106 CCT3 STRN 0.126 18782753 P50990 O55106 CCT8 STRN 0.126 18782753 P50991 O55106 CCT4 STRN 0.126 18782753 P67775 O55106 PPP2CA STRN 0.126 18782753 P78371 O55106 CCT2 STRN 0.126 18782753 Q8WZ74 O55106 CTTNBP2 STRN 0.126 18782753 Q92526 O55106 CCT6B STRN 0.126 18782753 Q99832 O55106 CCT7 STRN 0.126 18782753 Q9BUL8 O55106 PDCD10 STRN 0.126 18782753 Q9P289 O55106 MST4 STRN 0.126 18782753 Q9ULQ0 O55106 STRIP2 STRN 0.126 18782753 Q9H2K2 O55106 TNKS2 STRN 0.21 22153077 Q14BN4 O55106 SLMAP STRN 0.196 18782753,24255178 Q13033 O55106 STRN3 STRN 0.196 18782753,24255178 P30153 O55106 PPP2R1A STRN 0.196 18782753,24255178 Q9Y6E0 O55106 STK24 STRN 0.196 18782753,24255178 Q9NRL3 O55106 STRN4 STRN 0.196 18782753,24255178 Q5VSL9 O55106 STRIP1 STRN 0.196 18782753,24255178 Q9BRV8 O55106 SIKE1 STRN 0.196 18782753,24255178 Q9Y3A3 O55106 MOB4 STRN 0.196 18782753,24255178 Q9NVK5 O55106 FGFR1OP2 STRN 0.196 18782753,24255178 Q9P2B4 O55106 CTTNBP2NL STRN 0.196 18782753,24255178 P63101 O55106 YWHAZ STRN 0.126 16959763