PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Rictor Mlst8 18505677,22307628,18925875 innatedb,dip exp P Mlst8 Mtor 18505677,20801936,18851840 innatedb,biogrid,intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mapkap1 Mlst8 18851840 innatedb,biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rpf1 Mlst8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ddx55 Mlst8 ortho Rps3a Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Chuk Mlst8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rptor Mlst8 ortho P Xpo1 Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Flad1 Mlst8 ortho Supt5h Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rps9 Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pfdn2 Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pgam2 Mlst8 ortho GP G G G G G G G G G G G G Ppif Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ikbkb Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mlst8 Pfdn5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tsc2 Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rheb Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Foxf2 Mlst8 ortho G G G Cct6b Mlst8 ortho P G G Prr5 Mlst8 ortho G G G G Sqstm1 Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atp6v1b2 Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fchsd2 Mlst8 ortho Melk Mlst8 ortho G G G G G G G G G G G G G Mlst8 Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ndufs1 Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eif4ebp1 Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Wdr60 Mlst8 ortho Kif11 Mlst8 ortho G G G G G G G G G G Nudc Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atxn1 Mlst8 ortho Mlst8 Tsc1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ica1l Mlst8 ortho P Stat1 Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sec23a Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp54 Mlst8 ortho Fkbp8 Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mlst8 Fbp1 ortho GP G G G G G G G G G G G G G G G G G Igbp1 Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G Suz12 Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ulk1 Mlst8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct2 Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Setx Mlst8 ortho Ppp2ca Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Deptor Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Sec13 Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tuba1a Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mlst8 Lypla2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mlst8 Prmt1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg4a Mlst8 ortho Cct7 Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prr5l Mlst8 ortho Pgk1 Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G A2mp Mlst8 ortho P G G G G G G G G G G Appl2 Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct6a Mlst8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mlst8 Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fkbp2 Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Etv3 Mlst8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hmgcs1 Mlst8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspd1 Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mlst8 Jmjd6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stip1 Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nxf1 Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ftmt Mlst8 ortho G Sec61a1 Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mov10 Mlst8 ortho G G G G G G G G G G G G G G G G G G G G Syne4 Mlst8 ortho G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9DCJ1 anti bait coimmunoprecipitation 22307628 - C 4 Q9DCJ1 Q6QI06 anti bait coimmunoprecipitation 22307628 physical association X 2 Q9DCJ1 anti tag coimmunoprecipitation 17565979 association C 4 Q9DCJ1 Q9JLN9 anti tag coimmunoprecipitation 20801936 physical association X 2 Q9DCJ1 anti tag coimmunoprecipitation 17565979 association C 4

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Mlst8 Mtor MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology) 20801936 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_172030|BIOGRID_314603 bait|bait prey|prey Rps6kb1 Mlst8 MI:0415(enzymatic study) 17386266 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_322513 prey bait

PPI - HINT Gene A Gene B PMID Method Quality RICTOR MLST8 22307628 0006 LC MAPKAP1 MLST8 18851840 0004 LC MLST8 MTOR 20801936,18851840,20801936 0004,0004,0007 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9DCJ1 Q8N122 MLST8 RPTOR 0.21 17565979 Q9DCJ1 Q6R327 MLST8 RICTOR 0.21 17565979 Q9DCJ1 Q8BKH7 MLST8 MAPKAP1 0.21 18851840 Q9DCJ1 Q16531 MLST8 DDB1 0.21 18235224 Q9JLN9 Q9DCJ1 MTOR MLST8 0.376 20801936,18851840