PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Mib1 Dll4 23162128,16000382 biogrid exp G G Mib1 Jag2 16000382 biogrid exp G G G G G G G Ywhae Mib1 16615898 intact exp P G G G G G G G G G Dll3 Mib1 16000382 biogrid exp G G Mapk14 Mib1 15102471 mint,intact exp P G G G G G G G G G Mib1 Mib1 12351649 biogrid exp, ortho P G G G G G G G G G Mib1 Tbk1 21903422 biogrid,intact exp, ortho P G G G G G G G G G Mib1 Dapk1 23478405 biogrid exp, ortho G G G G G G G G Dll1 Mib1 23162128,16000382 biogrid exp, ortho G G G G G G G G Mib1 Jag1 16000382 biogrid exp, ortho G G G Ube2d2b Mib1 ortho P G Cep135 Mib1 ortho P Cdc27 Mib1 ortho G Mib1 Ssx2ip ortho G G G G G G G Blm Mib1 ortho G G Mib1 Stub1 ortho P G G G G G G G G G Cep162 Mib1 ortho Mib1 Mib2 ortho G G G G G G G G G Mib1 Cmip ortho G G G G G G G G G Ube2d2 Mib1 ortho P G G G G G G G G G Ryk Mib1 ortho G G G G G G G G Ddb1 Mib1 ortho P G G G G G G G G G Ube2n Mib1 ortho P Mcm7 Mib1 ortho P G G G G G G G G G Gem (Nuclear organelle) associated protein 4, Protein Gemin4 Mib1 ortho P Ube2d1 Mib1 ortho G G G G G G G G G Mcm3 Mib1 ortho P G G G G G G Dab2 Mib1 ortho G G G G G G G G Mib1 Ccdc14 ortho Mib1 Snx5 ortho P G G G G G G G G G Plk4 Mib1 ortho G G G G G Mib1 Pcm1 ortho P G G G G G G G G G Usp9x Mib1 ortho P G G G G G G G G G Mapre1 Mib1 ortho P G G G G G G G G G Cntrl Mib1 ortho G G G Mib1 Azi2 ortho G G G G G G G G G Dynll1 Mib1 ortho P G G G G G G G G G Mib1 Cep128 ortho Mib1 Top3b ortho P G G G G G G G G G Cenpj Mib1 ortho Mib1 Poc5 ortho G G G G Mib1 Med4 ortho G G G G G G G G G Rangap1 Mib1 ortho P G G G G G G G G G Ube2u Mib1 ortho Cep131 Mib1 ortho G Fat4 Mib1 ortho Protein Zbtb10 Mib1 ortho Fgfr1op Mib1 ortho Ubc Mib1 ortho P G G G G G G G G G Top3a Mib1 ortho G G G G Myc Mib1 ortho G G G G G G Notch1 Mib1 ortho G G G G G G G G Fsd1 Mib1 ortho Cep290 Mib1 ortho G G G Prkar2b Mib1 ortho P Per3 Mib1 ortho G G G G G G G G Ntrk1 Mib1 ortho Ube2d3 Mib1 ortho P G G G G G G G G G Rbbp4 Mib1 ortho P G G G G G G G G G Ccdc131 Mib1 ortho P Mib1 Ofd1 ortho G G G G G G Cep250 Mib1 ortho Mib1 Ube2w ortho G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P53355 Q80SY4 affinity chromatography technology 12351649 physical association X 2 P53355 Q80SY4 affinity chromatography technology 12351649 physical association X 2 P53355 Q80SY4 enzymatic study 12351649 direct interaction X 2 Q80SY4 Q9JI71 affinity chromatography technology 16000382 physical association X 2 Q80SY4 affinity chromatography technology 16000382 physical association X 2 Q80SY4 Q9JI71 affinity chromatography technology 23162128 physical association X 2 Q80SY4 Q3UKP8 affinity chromatography technology 23478405 physical association X 2 Q80SY4 Q9WUN2 affinity chromatography technology 21903422 physical association X 2 Q80SY4 Q9NWT6 two hybrid 25347788 direct interaction X 2 Q80SY4 P78559 two hybrid 25347788 direct interaction X 2 Q80SY4 B4DV00 two hybrid 25347788 direct interaction X 2 Q80SY4 Q9H2U1-2 two hybrid 25347788 direct interaction X 2 Q80SY4 O15519-13 affinity chromatography technology 19710364 physical association X 2 Q9QXX0 Q80SY4 affinity chromatography technology 16000382 physical association X 2 A0A024QZW3 Q80SY4 two hybrid 25347788 direct interaction X 2 Q80SY4 affinity chromatography technology 16000382 physical association X 2 P0CG48 Q80SY4 affinity chromatography technology 12351649 physical association X 2 P0CG48 Q80SY4 affinity chromatography technology 19710364 physical association X 2 Q80SY4 affinity chromatography technology 16857196 physical association X 2 Q80SY4 affinity chromatography technology 16857196 physical association X 2 Q80SY4 Q61483 affinity chromatography technology 16000382 physical association X 2 Q80SY4 Q61483 affinity chromatography technology 23162128 physical association X 2 Q80SY4 Q9Y5X3 two hybrid 25347788 direct interaction X 2 Q80SY4 Q80SY4 enzymatic study 12351649 direct interaction X 2 Q80SY4 anti bait coimmunoprecipitation 21903422 association C 3 Q8IY22 Q80SY4 anti tag coimmunoprecipitation 20018188 physical association X 2 Q8IY22 Q80SY4 anti tag coimmunoprecipitation 20018188 physical association X 2 Q80SY4 P47811 two hybrid 15102471 physical association X 2 Q80SY4 Q6DI32 anti tag coimmunoprecipitation 16857196 physical association X 2 Q80SY4 Q6DI32 anti tag coimmunoprecipitation 16857196 physical association X 2 Q80SY4 Q6DI32 anti tag coimmunoprecipitation 16857196 physical association X 2 Q80SY4 Q6DI32 fluorescence microscopy 16857196 colocalization X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Dll1 Mib1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16000382,23162128 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_323965|BIOGRID_325011 prey|bait bait|prey Mib1 Tbk1 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 21903422 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_331647|UniProt_172673 prey|prey bait|bait Mib1 Dll4 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16000382,23162128 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_323967|BIOGRID_325012 bait|prey prey|bait Mib1 Dapk1 MI:0004(affinity chromatography technology) 23478405 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_328845 bait prey Mapk14 Mib1 MI:0018(two hybrid) 15102471 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_162933 bait prey Mib1 Jag1 MI:0004(affinity chromatography technology) 16000382 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_323968 bait prey Dll3 Mib1 MI:0004(affinity chromatography technology) 16000382 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_323966 prey bait Mib1 Jag2 MI:0004(affinity chromatography technology) 16000382 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_323969 bait prey

PPI - HINT Gene A Gene B PMID Method Quality MAPK14 MIB1 15102471 0018 LC YWHAE MIB1 16615898 0027 LC MIB1 MIB1 12351649 0415 LC DLL3 MIB1 16000382 0004 LC DLL1 MIB1 16000382,23162128 0004,0004 LC MIB1 DAPK1 23478405 0004 LC MIB1 DLL4 16000382,23162128 0004,0004 LC MIB1 JAG1 16000382 0004 LC MIB1 JAG2 16000382 0004 LC MIB1 TBK1 21903422,21903422 0006,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q80SY4 Q61483 MIB1 DLL1 0.376 23162128,16000382 Q80SY4 P62259 MIB1 YWHAE 0.081 16615898 Q9JI71 Q80SY4 DLL4 MIB1 0.376 23162128,16000382 Q8IY22 Q80SY4 CMIP MIB1 0.21 20018188 Q80SY4 E7ERK7 MIB1 TBC1D31 {ECO:0000313|ENSEMBL:ENSP00000429334} 0.126 26496610 Q80SY4 E7ETA6 MIB1 PCM1 {ECO:0000313|ENSEMBL:ENSP00000431099} 0.126 26496610 Q80SY4 J3QT39 MIB1 J3QT39 0.126 26496610 Q80SY4 O14744 MIB1 PRMT5 0.309 25347788 Q80SY4 O15519 MIB1 CFLAR 0.21 19710364 Q80SY4 O88516 MIB1 DLL3 0.21 16000382 Q80SY4 P47811 MIB1 MAPK14 0.183 15102471 Q80SY4 P78559 MIB1 MAP1A 0.309 25347788 Q80SY4 Q49A88 MIB1 CCDC14 0.126 26496610 Q80SY4 Q80SY4 MIB1 MIB1 0.332 12351649 Q80YE7 Q80SY4 DAPK1 MIB1 0.21 23478405 Q96DN5 Q80SY4 TBC1D31 MIB1 0.126 26496610 Q96S59 Q80SY4 RANBP9 MIB1 0.309 25347788 Q9H2U1 Q80SY4 DHX36 MIB1 0.309 25347788 Q9NWT6 Q80SY4 HIF1AN MIB1 0.309 25347788 Q9QXX0 Q80SY4 JAG1 MIB1 0.21 16000382 Q9QYE5 Q80SY4 JAG2 MIB1 0.21 16000382 Q9Y5X3 Q80SY4 SNX5 MIB1 0.309 25347788 Q9WUN2 Q80SY4 TBK1 MIB1 0.236 21903422 Q80SY4 Q6DI32 MIB1 SNX5 0.309 16857196 Q80SY4 Q15154 MIB1 PCM1 0.236 26496610 Q80SY4 Q14146 MIB1 URB2 0.236 26496610 Q80SY4 Q13057 MIB1 COASY 0.236 26496610 Q80SY4 P54577 MIB1 YARS 0.236 26496610 Q80SY4 O75665 MIB1 OFD1 0.236 26496610 Q80SY4 O14828 MIB1 SCAMP3 0.236 26496610 Q9HD15 Q80SY4 SRA1 MIB1 0.236 26496610 Q8N5G2 Q80SY4 TMEM57 MIB1 0.236 26496610 Q80SY4 Q3KQU3 MIB1 MAP7D1 0.236 26496610 Q80SY4 Q2KHM9 MIB1 KIAA0753 0.236 26496610 Q80SY4 Q5VT06 MIB1 CEP350 0.236 26496610 Q80SY4 Q5T9S5 MIB1 CCDC18 0.236 26496610 Q80SY4 Q5TCZ1 MIB1 SH3PXD2A 0.236 26496610 Q9BR77 Q80SY4 CCDC77 MIB1 0.236 26496610 Q96KA5 Q80SY4 CLPTM1L MIB1 0.236 26496610 Q8WX93 Q80SY4 PALLD MIB1 0.236 26496610 Q8WXW3 Q80SY4 PIBF1 MIB1 0.236 26496610 Q9BQE3 Q80SY4 TUBA1C MIB1 0.236 26496610 Q96NB1 Q80SY4 FOPNL MIB1 0.236 26496610 Q96RK4 Q80SY4 BBS4 MIB1 0.236 26496610 Q9Y6R9 Q80SY4 CCDC61 MIB1 0.236 26496610 Q9P209 Q80SY4 CEP72 MIB1 0.236 26496610 Q9UPN4 Q80SY4 CEP131 MIB1 0.236 26496610 Q80SY4 P53355 MIB1 DAPK1 0.569 12351649