PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ring1 Runx1 22325351 biogrid exp G G G G G G G G G G G G G G Ring1 Ywhae 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Kdm2b 17296600 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Rybp 10369680,17070805,22325148 biogrid,i2d,intact exp Ring1 Pcgf2 16359901,22325148 biogrid,intact exp, ortho G G G G G Ring1 Bmi1 16359901 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Phc2 16359901,12183370 biogrid,i2d,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Cbx8 16359901 i2d,intact exp, ortho G G G G G G G G G Ring1 Eed 24457600 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Ring1 16359901 intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Cbx7 22325148 biogrid exp, ortho G G G G G G G G G G G G G G G G Ring1 Rnf2 24457600,17296600,16359901,22496869 biogrid,i2d,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Cbx2 10369680,9312051 biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Yy1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Zfp42 ortho G G Ring1 Cbx3 ortho P G G Ring1 Xpo1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Phc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Ube2e2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Ube2e3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Ubc ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 E2f6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Snai1 ortho G G G Ring1 Cbx6 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Hecw2 ortho Ring1 Csnk2a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Top2a ortho G G G G G G G G G G G G G G G G G G G G Ring1 Mov10 ortho G G G G G G G G G G G G G G G G G G Ring1 Phc3 ortho Ring1 Smarcad1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Ube2d2b ortho P G Ring1 Usp7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Cbx4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Usp11 ortho G G G G G G G G G G G G G G G G G G G G Ring1 Rb1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Tp53 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Elac2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Yy2 ortho Ring1 Ube2k ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Wdr5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 PcgF3 ortho Ring1 Pcgf6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Notch1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Csnk2a2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Fhl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Ube2d1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Pcgf1 ortho G G G G G G G G G G G G G G G G Ring1 Jun ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Kdm5c ortho P G G G G G G G G Ring1 Ube2e1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Hdac1 Ring1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Pcgf5 ortho Ring1 App ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Aim2 ortho G G Ring1 Bcor ortho Ring1 Ube2d3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Terf1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Ube2d2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 E2f1 ortho G G G Ring1 Snw1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Med23 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Terf2 Ring1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Auts2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Cenpa Ring1 ortho G G G G G G G G G G G G G G G G G Ring1 Pik3r3 ortho P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O35730 G3X9W7 affinity chromatography technology 22325351 physical association X 2 O35730 Q9QWH1-2 two hybrid 12183370 direct interaction X 2 O35730 Q921E6 affinity chromatography technology 24457600 physical association X 2 O35730 Q921E6 affinity chromatography technology 24457600 physical association X 2 O35730 P30658 two hybrid 9312051 direct interaction X 2 O35730 P30658 pull down 9312051 direct interaction X 2 O35730 Q16777 enzymatic study 16710298 direct interaction X 2 P23798 O35730 affinity chromatography technology 22325148 physical association X 2 Q8CCI5 O35730 affinity chromatography technology 22325148 physical association X 2 Q8CCI5 O35730 affinity chromatography technology 17070805 physical association X 2 O35730 Q9CQJ4 affinity chromatography technology 22496869 physical association X 2 O35730 Q8VDS3 affinity chromatography technology 22325148 physical association X 2 O35730 Q9CQJ4 affinity chromatography technology 24457600 physical association X 2 O35730 Q9CQJ4 affinity chromatography technology 24457600 physical association X 2 O35730 Q9CQJ4 affinity chromatography technology 17296600 physical association X 2 O35730 Q6P1G2-4 affinity chromatography technology 17296600 physical association X 2 O35730 Q6P1G2-4 affinity chromatography technology 17296600 physical association X 2 O35730 anti tag coimmunoprecipitation 22325148 association C 10 O35730 molecular sieving 16359901 physical association C 3 O35730 anti tag coimmunoprecipitation 16359901 association C 4 O35730 pull down 17296600 association C 52 O35730 P30658 pull down 10369680 direct interaction X 2 O35730 P25916 pull down 16359901 physical association X 2 O35730 P25916 pull down 16359901 physical association X 2 O35730 Q9QWH1 pull down 16359901 physical association X 2 O35730 Q9QWH1 pull down 16359901 physical association X 2 O75461 O35730 coimmunoprecipitation 11171983 physical association X 2 O35730 anti tag coimmunoprecipitation 22325148 association C 6 O35730 pull down 17296600 association C 9 O35730 anti tag coimmunoprecipitation 16359901 association C 4 O35730 anti tag coimmunoprecipitation 22325148 association C 10 O35730 pull down 17296600 association C 11 Q8CCI5 O35730 pull down 10369680 direct interaction X 2 Q8CCI5 O35730 anti bait coimmunoprecipitation 10369680 physical association X 2 Q8CCI5 O35730 two hybrid 10369680 physical association X 2 O35730 Q9QXV1 pull down 16359901 physical association X 2 O35730 Q9QXV1 pull down 16359901 physical association X 2 O35730 Q9CQJ4 pull down 16359901 physical association X 2 O35730 O35730 pull down 16359901 physical association X 2 O35730 Q9CQJ4 anti bait coimmunoprecipitation 17296600 physical association X 2 O35730 Q9QXV1 two hybrid 10721694 - X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Ring1 Runx1 MI:0004(affinity chromatography technology) 22325351 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_320747 prey bait Ring1 Kdm2b MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down) 17296600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association) (intact)|(biogrid)|(biogrid)|(intact) UniProt_166520|BIOGRID_315750|BIOGRID_315764|UniProt_166513 prey|prey|prey|prey bait|bait|bait|bait Ring1 Eed MI:0027(cosedimentation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16615898,24457600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid) UniProt_167137|BIOGRID_331763|BIOGRID_331765 neutral component|prey|bait neutral component|bait|prey Ring1 Cbx7 MI:0004(affinity chromatography technology) 22325148 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_320774 prey bait Ring1 Pcgf2 MI:0071(molecular sieving)|MI:0004(affinity chromatography technology)|MI:0071(molecular sieving)|MI:0007(anti tag coimmunoprecipitation) 16359901,22325148 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association) (intact)|(biogrid)|(intact)|(intact) UniProt_174819|BIOGRID_320764|UniProt_174857|UniProt_165958 prey|prey|prey|prey bait|bait|bait|bait Ring1 Bmi1 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 16359901 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association) (intact)|(intact)|(intact)|(intact) UniProt_165978|UniProt_165965|UniProt_165959|UniProt_165957 neutral component|prey|bait|prey neutral component|bait|prey|bait Ring1 Cbx2 MI:0096(pull down)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid) 10369680,9312051 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(biogrid)|(intact)|(biogrid) UniProt_160384|BIOGRID_315450|UniProt_66130|BIOGRID_315449 bait|prey|bait|prey prey|bait|prey|bait Ring1 Rybp MI:0071(molecular sieving)|MI:0027(cosedimentation)|MI:0096(pull down)|MI:0096(pull down)|MI:0027(cosedimentation)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down) 10369680,16615898,17070805,22325148 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0403(colocalization)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(intact)|(biogrid)|(biogrid)|(intact)|(intact) UniProt_174817|UniProt_167137|UniProt_66127|UniProt_160381|UniProt_167133|BIOGRID_316004|BIOGRID_320768|UniProt_160378|UniProt_160380 prey|neutral component|prey|prey|neutral component|prey|prey|bait|bait bait|neutral component|bait|bait|neutral component|bait|bait|prey|prey Ring1 Cbx8 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 16359901 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_165970|UniProt_165960 prey|bait bait|prey Ring1 Phc2 MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation) 12183370,16359901,16615898 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(biogrid)|(intact) UniProt_167137|UniProt_167121|UniProt_167117|UniProt_167133|UniProt_167125|UniProt_165973|BIOGRID_328947|UniProt_165961 neutral component|neutral component|neutral component|neutral component|neutral component|prey|prey|bait neutral component|neutral component|neutral component|neutral component|neutral component|bait|bait|prey Ring1 Rnf2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0027(cosedimentation)|MI:0007(anti tag coimmunoprecipitation)|MI:0027(cosedimentation)|MI:0096(pull down)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation) 16359901,16615898,17296600,22496869,24457600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0403(colocalization)|MI:0914(association)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization) (biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact) BIOGRID_331766|BIOGRID_320480|UniProt_166518|BIOGRID_331768|BIOGRID_315679|UniProt_165976|UniProt_167137|UniProt_165978|UniProt_167121|UniProt_166511|UniProt_167117|UniProt_167133|UniProt_167125 bait|prey|bait|prey|prey|bait|neutral component|neutral component|neutral component|prey|neutral component|neutral component|neutral component prey|bait|prey|bait|bait|prey|neutral component|neutral component|neutral component|bait|neutral component|neutral component|neutral component

PPI - HINT Gene A Gene B PMID Method Quality RING1 BMI1 16359901,16359901,16359901 0007,0071,0096 LC RING1 CBX2 9312051,9312051 0096,0018 LC RING1 YWHAE 16615898 0027 LC RING1 RYBP 10369680,10369680,10369680 0006,0018,0096 LC RING1 PHC2 12183370 0018 LC RING1 CBX8 10721694 0018 LC RING1 RING1 16359901 0096 LC RING1 PCGF2 22325148,22325148,16359901 0004,0007,0007 LC RING1 BMI1 16359901,16359901,16359901 0007,0071,0096 LC RING1 CBX2 9312051,10369680,9312051 0096,0096,0018 LC RING1 RUNX1 22325351 0004 LC RING1 KDM2B 17296600,17296600 0096,0004 LC RING1 RYBP 10369680,17070805,10369680,22325148,10369680,22325148 0006,0004,0018,0004,0096,0007 LC RING1 CBX7 22325148 0004 LC RING1 EED 24457600 0004 LC RING1 RNF2 17296600,24457600,16359901,17296600,17296600,22496869 0004,0004,0096,0096,0006,0004 LC RING1 PHC2 16359901 0096 LC RING1 CBX8 16359901 0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P62259 O35730 YWHAE RING1 0.081 16615898 Q8VDS3 O35730 CBX7 RING1 0.126 22325148 O75461 O35730 E2F6 RING1 0.21 11171983 Q16777 O35730 HIST2H2AC RING1 0.309 16710298 O35730 J3KQH6 RING1 PHC1 {ECO:0000313|ENSEMBL:ENSP00000399194} 0.126 26496610 P78364 O35730 PHC1 RING1 0.126 26496610 O35730 J3KNZ9 RING1 FBRS {ECO:0000313|ENSEMBL:ENSP00000348489} 0.126 26496610 Q9HAH7 O35730 FBRS RING1 0.126 26496610 P23798 O35730 PCGF2 RING1 0.236 22325148 Q6P1G2 O35730 KDM2B RING1 0.236 17296600 O35730 A8MT69 RING1 STRA13 0.236 26496610 P61964 O35730 WDR5 RING1 0.236 26496610 P14373 O35730 TRIM27 RING1 0.236 26496610 O35730 O00257 RING1 CBX4 0.236 26496610 O43633 O35730 CHMP2A RING1 0.236 26496610 P55201 O35730 BRPF1 RING1 0.236 26496610 P35226 O35730 BMI1 RING1 0.236 26496610 Q8CCI5 O35730 RYBP RING1 0.772 22325148,17070805,10369680 Q86SQ0 O35730 PHLDB2 RING1 0.236 26496610 Q6W2J9 O35730 BCOR RING1 0.236 26496610 Q8IY57 O35730 YAF2 RING1 0.236 26496610 Q969R5 O35730 L3MBTL2 RING1 0.236 26496610 Q8IXK0 O35730 PHC2 RING1 0.236 26496610 Q8IWI9 O35730 MGA RING1 0.236 26496610 Q8NDX5 O35730 PHC3 RING1 0.236 26496610 Q8N488 O35730 RYBP RING1 0.236 26496610 Q93009 O35730 USP7 RING1 0.236 26496610 Q9BXI9 O35730 C1QTNF6 RING1 0.236 26496610 Q9UQ90 O35730 SPG7 RING1 0.236 26496610 Q9BSM1 O35730 PCGF1 RING1 0.236 26496610 Q99496 O35730 RNF2 RING1 0.236 26496610 Q9BYE7 O35730 PCGF6 RING1 0.236 26496610 Q9HC52 O35730 CBX8 RING1 0.236 26496610 Q9CQJ4 O35730 RNF2 RING1 0.554 22496869,17296600,24457600 Q9UQR0 O35730 SCML2 RING1 0.236 26496610 P30658 O35730 CBX2 RING1 0.671 10369680,9312051 Q921E6 O35730 EED RING1 0.236 24457600 Q9QWH1 O35730 PHC2 RING1 0.309 12183370