PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Akt1 Ppp2r2b 16051150 biogrid exp P G G G G G G G G G G G Ppp2r2b Arrb2 16051150 biogrid exp P G G G G G G G G G G Ppp2r2b Bag2 ortho P G G G G G G G G G G G Ppp2r2b Csnk1a1 ortho P G G G G G G G G G G G Hnrnpa2b1 Ppp2r2b ortho P G G G G G G G G G G G Ppp2r2b Mccc1 ortho P G G G G G G G G G G G Ppp2r2b Gabarap ortho P G G G G G G G G G G G Smad2 Ppp2r2b ortho P G G G G G G G G G G G Ywhae Ppp2r2b ortho P G G G G G G G G G G G Pc Ppp2r2b ortho P G G G G G G G G G G G Ppp2r2b Ogt ortho P G G G G G G G G G G G Rps8 Ppp2r2b ortho P Tgfbr1 Ppp2r2b ortho G G G G G G G G G G G Ppp4c Ppp2r2b ortho P G G G G G G G G G G G Eef1a1 Ppp2r2b ortho P G G G G G G G G G G G Ppp2r2b Ska2 ortho G G G G G G G G G G G Hspa8 Ppp2r2b ortho P G G G G G G G G G G G Ppp2r2b Psd4 ortho Rpl30 Ppp2r2b ortho P Cct7 Ppp2r2b ortho P G G G G G G G G G G G Cftr Ppp2r2b ortho G G Ppp2r2b Pdpk1 ortho G G G G G G G G G G G Mccc2 Ppp2r2b ortho P G G G G G G G G Trim28 Ppp2r2b ortho P G G G G G G G G G G G Prph Ppp2r2b ortho P G G G Anxa2 Ppp2r2b ortho P G G G G G G G G G G G Ppp2r2b Tufm ortho P G G G G G G G G G G G Capzb Ppp2r2b ortho P G G G G G G G G G G G Rps23 Ppp2r2b ortho P Nufip2 Ppp2r2b ortho P Ybx1 Ppp2r2b ortho P G G G G G G G G G G G Smad4 Ppp2r2b ortho P G G G G G G G G G G G Rpl12 Ppp2r2b ortho P G G G G G G G G G G G Ppp2r2b Rpl11 ortho P G G G G G G G G G G G Protein Krt78 Ppp2r2b ortho P Ppp2r2b Matr3 ortho P G G G G G G G G G G G Ppp2r2b Skiv2l2 ortho P G G G G G G G G G G G Hnrnph1 Ppp2r2b ortho P G G G G G G G G G G G Mtcl1 Ppp2r2b ortho Ppp2r2b Serbp1 ortho P G G G G G G G G G G G Sertad4 Ppp2r2b ortho Capza1 Ppp2r2b ortho P G G G G G G G G G G G Ppp2r2b Smc4 ortho P G G G G G G G G G G G Prdx3 Ppp2r2b ortho P G G G G G G G G G G G Ppp2r2b Smad3 ortho G G G G G G G Ppp2r2b Ahi1 ortho G G G G G G G G G G G Ppp2r2b Hnrnpl ortho P G G G G G G G G G G G Acacb Ppp2r2b ortho P G G G G G Ppp2r2b Nkd1 ortho G G G Ech1 Ppp2r2b ortho P G G G G G G G G G G G Ppp2r2b Atxn2l ortho P Ppp2r2b Sugp2 ortho G G G G G G G G G G G Myl6 Ppp2r2b ortho P G G G G G G G G G G Prdx1 Ppp2r2b ortho P Ppp2r2b Cdca4 ortho G G G G G G G G G G Krt32 Ppp2r2b ortho P G G Ppp2r2b Fam122a ortho P G G G G G G G G G G G Ddx3x Ppp2r2b ortho P G G G G G G G G G G G Ppp2r2b Ppp2r1b ortho P G G G G G G G G G G Vhl Ppp2r2b ortho G G G G G G G G G G Ddx17 Ppp2r2b ortho P G G G G G G G G G G G Hcfc1 Ppp2r2b ortho P G G G G G G G G G G G Krt14 Ppp2r2b ortho P G G Rpl23 Ppp2r2b ortho P Rps14 Ppp2r2b ortho P G G G G G G G G G G G Ppp2r2b Recql4 ortho G Hnrnpk Ppp2r2b ortho P G G G G G G G G G G G Ppp2r2b Rpl4 ortho P G G G G G G G G G G G S100a9 Ppp2r2b ortho P G G G G G G Ran Ppp2r2b ortho P G G G G G G G G G G G Ppp2r2b Hnrnpu ortho P G G G G G G G G G G G Cct4 Ppp2r2b ortho P G G G G G G G G G G G C1qbp Ppp2r2b ortho P G G G G G G G G G G G S100a8 Ppp2r2b ortho G G G G G G G Ppp2r2b Grpel1 ortho P G G G G G G G G G G G Pabpc1 Ppp2r2b ortho P G G G G G G G G G G G Ppp2r2b Ska3 ortho Rps6 Ppp2r2b ortho P G G G G G G G G G G G Ppp2r2b Iqgap1 ortho P G G G G G G G G G G G Ppp2r2b Hnrnpf ortho P G G G G G G G G G G G Ppp2r2b Pcca ortho P G G G G G G G G G G G Prdx4 Ppp2r2b ortho P G G G G G G G G G G G Jun Ppp2r2b ortho G G G G G G G G G G G Tubb5 Ppp2r2b ortho P G G G G G G G G G G G Ppp2r2b Cul3 ortho P G G G G G G G G G G G Ppp2r2b Krt16 ortho P G Ppp2r2b Pccb ortho P G G G G G G G G G G G Actb Ppp2r2b ortho P G G G G G G G G G G G Rpl21 Ppp2r2b ortho P Kpnb1 Ppp2r2b ortho P G G G G G G G G G G G Ppp2r2b MCG140784, Protein Try10, Trypsin 10, Trypsinogen 10 ortho P Rac1 Ppp2r2b ortho P G G G G G G G G G G G Cct5 Ppp2r2b ortho P G G G G G G G G G G G Tubb4b Ppp2r2b ortho P G G G G G G G G G G G Tuba1b Ppp2r2b ortho P G G G G G G G G G G G Ppp2r2b Ppp2r2c ortho P Ppp2r2b Mrpl12 ortho P G G G G G G G G G G G Ppp2r2b Prpf40a ortho P G G G G G G G G G G G Ppp2r2b Lsm12 ortho G G G G G G G G G G G Dynll1 Ppp2r2b ortho P G G G G G G G G G G G Ppp2r2b Zcchc8 ortho P G G G G G G G G G G G Ppp2r2b Mrps27 ortho P Ppp2r2b Ccar2 ortho P G G G G G G G G G G G Tuba1c Ppp2r2b ortho P Rplp2 Ppp2r2b ortho P G G G G G G G G G G G Ppp2ca Ppp2r2b ortho P G G G G G G G G G G G Ppp2r2b Myo9a ortho G G G G G G G G G G G Ppp2r2b Krt81 ortho G G G G G G G G G G G Zfp295 Ppp2r2b ortho G G G G G G G G G G G Ppp2r2b Sik2 ortho Ppp2r2b Rpl14 ortho P G G G G G G G G G G G Ppp2r2b Chek2 ortho G G G G G Ppp2r2b Rps27l ortho P G G G G G G G G G G G Ppp2r2b Ska1 ortho G Dsp Ppp2r2b ortho P G G G G G G G G Ppp2r2b Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase ortho G G G G G G G G G G G Ier2 Ppp2r2b ortho G G G G G G G G G G Rps11 Ppp2r2b ortho P G G G G G G G G G G G Acaca Ppp2r2b ortho P G G Rpl19 Ppp2r2b ortho P G G G G G G G G G G G Tcp1 Ppp2r2b ortho P G G G G G G G G G G G Cct2 Ppp2r2b ortho P G G G G G G G G G G G Cct3 Ppp2r2b ortho P G G G G G G G G G G G Ddx6 Ppp2r2b ortho P G G G G G G G G G G G Tp53 Ppp2r2b ortho G G G G G G G G G G Map7 Ppp2r2b ortho P G G G G G G G G G G G Rplp0 Ppp2r2b ortho P G G G G G G G G G G G Eef1a2 Ppp2r2b ortho P G G G G G G G G G G G Cad Ppp2r2b ortho P G G G G G G G G G G G Ppp2r2b Csnk1e ortho G G G G G G G G G G Axin1 Ppp2r2b ortho G G G G G G G G G G G Hspa5 Ppp2r2b ortho P G G G G G G G G G G G Krt1 Ppp2r2b ortho P G G G G G G Ppp2r2b Ptk2b ortho P G G G G G G G G G G Ppp2r2b Gabarapl1 ortho P G G G G G G G G G G G Zc3hav1 Ppp2r2b ortho P Cct6a Ppp2r2b ortho G G G G G G G G G G G Hspd1 Ppp2r2b ortho P G G G G G G G G G G G Top1 Ppp2r2b ortho G G G G G G G G G G G Ppp2r2b Ppp2r2b ortho P G G G G G G G G G G G Eef1b Ppp2r2b ortho P G G G G G G G G G G G Mcm5 Ppp2r2b ortho P G G G G Hsp90aa1 Ppp2r2b ortho P G G G G G G G G G G G Ppp2cb Ppp2r2b ortho P G G G G G G G G G G G Rps27a Ppp2r2b ortho P Protein Mki67 Ppp2r2b ortho P G G G G G G Ppp2r2b Ppp2r1a ortho P G G G G G G G G G G G Ppp2r2b Pak2 ortho P G G G G G G G G G G G Ppp2r2b Rpl24 ortho Rpl7a Ppp2r2b ortho P G G G G G G G G G G G Elavl1 Ppp2r2b ortho P G G G G G G G G G G G Ppp2r2b Hcfc2 ortho Ppp2r2b Krt5 ortho P G G G G Alb Ppp2r2b ortho P G G G G G G G G Cct8 Ppp2r2b ortho P G G G G G G G G G G G Vim Ppp2r2b ortho P G G G G G G G G G G G Gabarapl2 Ppp2r2b ortho P G G G G G G G G G G G Hspa9 Ppp2r2b ortho P G G G G G G G G G G G Ppp2r2b Ddx21 ortho P G G G G G G G G G G Ppp2r2b Raf1 ortho G G G G G G G G G G G Ppp2r2b Mlh1 ortho G G G G G G G G G G G Jup Ppp2r2b ortho P G G G G G G G G G G G Klhl15 protein, MCG5462, Protein Klhl15 Ppp2r2b ortho Ier5 Ppp2r2b ortho G G G G G G G G G G G Ppp2r2b Rbm7 ortho P G G G G G G G G G G G Ppp2r2b Rps6kb1 ortho P G G G G G G G G G G G Nme2 Ppp2r2b ortho P G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q91YI4 Q6ZWR4 pull down 16051150 direct interaction X 2 Q91YI4 Q6ZWR4 affinity chromatography technology 16051150 physical association X 2 Q6ZWR4 P31750 affinity chromatography technology 16051150 physical association X 2 Q6ZWR4 anti bait coimmunoprecipitation 12932319 association C 4 Q6ZWR4 pull down 12932319 association C 4 Q6ZWR4 pull down 16051150 association C 3

PPI - HINT Gene A Gene B PMID Method Quality PPP2R2B ARRB2 16051150,16051150,16051150 0096,0019,0004 LC AKT1 PPP2R2B 16051150 0004 LC PPP2R2B ARRB2 16051150,16051150,16051150 0096,0019,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q91YI4 Q6ZWR4 ARRB2 PPP2R2B 0.454 16051150 Q6ZWR4 P31750 PPP2R2B AKT1 0.21 16051150 Q6ZWR4 P32121 PPP2R2B ARRB2 0.21 16051150