PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Pax3 Tle4 15729346 biogrid,i2d exp G G G G Otx1 Tle4 i2d exp Aes Tle4 16002402 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Otx2 Tle4 i2d exp G Lef1 Tle4 15729346 biogrid exp G G G Tle4 Six6 12050133 biogrid,i2d,intact exp G G G Tle4 Tle4 16002402 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Six3 Tle4 12050133 biogrid,i2d,intact exp, ortho G G G G G G G G Pou2f1 Tle4 16002402 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Msx1 Tle4 16002402 biogrid exp, ortho G G G G G G G G G G G G G G G G G G Cdkn2c Tle4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Tle4 Arl4d ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Atn1 Tle4 ortho G G G G G G G G G G G G G G G G G G G G G G G G Protein Btbd2 Tle4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Tle4 Arl3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf10 Tle4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tle4 Polb ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tle4 Qprt ortho G G G Pou2f2 Tle4 ortho G G G Tle4 Dazap2 ortho Tle1 Tle4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Brca1 Tle4 ortho G G G G G G G G G G G G G Erh Tle4 ortho Tle4 Fubp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Serpinb9, SPI6, Serine (Or cysteine) peptidase inhibitor, clade B, member 9 Tle4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tle4 Tbx20 ortho G G G Srpk2 Tle4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tle4 Tle2 ortho G G G G G G G G G G G G G G G G G Tle4 Tssc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tle4 Prmt5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tle4 Zfp64 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tle4 Psmd11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hdac1 Tle4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tle4 Mphosph6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G H2-Aa Tle4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tle4 Glutathione S-transferase mu 4, Glutathione S-transferase, mu 4, Glutathione transferase GSTM7-7, Protein Gstm4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tle4 Celf3 ortho Pax5 Tle4 ortho G G Pafah1b3 Tle4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Tk1 Tle4 ortho G G G G G G G G G G G G G Pfn1 Tle4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pole2 Tle4 ortho G G G G G G G G G G G G G G G Tle4 Eif2s2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rpa2 Tle4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Tle3 Tle4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppm1b Tle4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tle4 Lig4 ortho Pex2 Tle4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tle4 Foxb1 ortho Tle4 Pcdha9 ortho Ccdc183 Tle4 ortho Tle4 Wdr77 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sat1 Tle4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tle4 Fxyd6 ortho G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q62441 - 15729346 - C 3 Q9QZ28 Q62441 - 12050133 - X 2 Q62233 Q62441 - 12050133 - X 2 P13297 Q62441 affinity chromatography technology 16002402 physical association X 2 P13297 Q62441 affinity chromatography technology 16002402 physical association X 2 Q9QZ28 Q62441 pull down 12050133 direct interaction X 2 Q62233 Q62441 pull down 12050133 direct interaction X 2 Q62233 Q62441 affinity chromatography technology 12050133 physical association X 2 P27782 Q62441 pull down 15729346 direct interaction X 2 Q3TZM4 Q62441 affinity chromatography technology 15729346 physical association X 2 Q3TZM4 Q62441 affinity chromatography technology 15729346 physical association X 2 Q95RW8 Q62441 pull down 12050133 direct interaction X 2 Q62441 P25425-7 affinity chromatography technology 16002402 physical association X 2 Q62441 Q62441 affinity chromatography technology 16002402 physical association X 2 Q62441 P25425-7 affinity chromatography technology 16002402 physical association X 2 P63002 Q62441 affinity chromatography technology 16002402 physical association X 2 P63002 Q62441 affinity chromatography technology 16002402 physical association X 2 Q62441 coimmunoprecipitation 15729346 association C 3 Q9QZ28 Q62441 pull down 12050133 direct interaction X 2 Q62233 Q62441 anti tag coimmunoprecipitation 12050133 physical association X 2 Q62233 Q62441 pull down 12050133 direct interaction X 2 Q95RW8 Q62441 pull down 12050133 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Aes Tle4 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16002402 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_323028|BIOGRID_323023 prey|bait bait|prey Msx1 Tle4 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16002402 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_323029|BIOGRID_323031 prey|bait bait|prey Lef1 Tle4 MI:0004(affinity chromatography technology) 15729346 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_314900 bait prey Pou2f1 Tle4 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16002402 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_323030|BIOGRID_323020 prey|bait bait|prey Tle4 Six6 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 12050133 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(intact)|(biogrid) UniProt_160732|UniProt_39041|BIOGRID_311601 bait|bait|bait prey|prey|prey Pax3 Tle4 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15729346 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_314896|BIOGRID_314897 prey|bait bait|prey Six3 Tle4 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 12050133 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(intact)|(biogrid)|(biogrid) UniProt_160731|UniProt_39040|UniProt_160738|BIOGRID_311603|BIOGRID_311600 prey|prey|prey|prey|prey bait|bait|bait|bait|bait Tle4 Optix MI:0096(pull down)|MI:0096(pull down) 12050133 taxid:10090(Mus musculus) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(intact) UniProt_160733|UniProt_39042 bait|bait prey|prey

PPI - HINT Gene A Gene B PMID Method Quality PAX3 TLE4 15729346,15729346 0004,0019 LC SIX3 TLE4 12050133,12050133,12050133,12050133 0004,0019,0096,0007 LC MSX1 TLE4 16002402 0004 LC PAX3 TLE4 15729346,15729346 0004,0019 LC POU2F1 TLE4 16002402 0004 LC LEF1 TLE4 15729346 0096 LC AES TLE4 16002402 0004 LC SIX3 TLE4 12050133,12050133,12050133,12050133 0004,0019,0096,0007 LC TLE4 TLE4 16002402 0004 LC TLE4 SIX6 12050133,12050133 0004,0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q62441 P24610 TLE4 PAX3 0.376 15729346 Q62441 P25425 TLE4 POU2F1 0.376 16002402 Q9QZ28 Q62441 SIX6 TLE4 0.309 12050133 Q62441 P13297 TLE4 MSX1 0.376 16002402 Q62441 Q62441 TLE4 TLE4 0.236 16002402 Q62441 Q62233 TLE4 SIX3 0.702 12050133 Q95RW8 Q62441 OPTIX TLE4 0.523 12050133 Q62441 P27782 TLE4 LEF1 0.309 15729346 Q62441 P63002 TLE4 AES 0.376 16002402