PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Dlg4 Otub1 19455133 intact exp P G G G G G G G G G Smad2 Otub1 24071738 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ndn Otub1 22442722 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G Otub1 Eed 24457600 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Otub1 Smad3 24071738 biogrid exp G G G G G G G G G G G G G G G Ywhah Otub1 21311561 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ywhae Otub1 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d2 Otub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g2 Otub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Otub1 Rnaseh2b ortho P Dcn Otub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Otub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Klhl8 Otub1 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q7TQI3 Q62432 affinity chromatography technology 24071738 physical association X 2 Q8BUN5 Q7TQI3 affinity chromatography technology 24071738 physical association X 2 Q7TQI3 P25233 two hybrid 22442722 direct interaction X 2 Q7TQI3 Q921E6 affinity chromatography technology 24457600 physical association X 2 Q7TQI3 cosedimentation 16615898 colocalization C 1216 Q7TQI3 anti tag coimmunoprecipitation 19455133 association C 226

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Smad2 Otub1 MI:0004(affinity chromatography technology) 24071738 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_331548 prey bait Otub1 Eed MI:0004(affinity chromatography technology) 24457600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_332694 prey bait Otub1 Smad3 MI:0004(affinity chromatography technology) 24071738 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_331549 bait prey Ndn Otub1 MI:0004(affinity chromatography technology) 22442722 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_323068 bait prey

PPI - HINT Gene A Gene B PMID Method Quality NDN OTUB1 22442722 0018 LC YWHAE OTUB1 16615898 0027 LC YWHAH OTUB1 21311561 0030 LC UBC OTUB1 26811477 0004 LC DLG4 OTUB1 19455133 0007 LC SMAD2 OTUB1 24071738 0004 LC OTUB1 SMAD3 24071738 0004 LC OTUB1 EED 24457600 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q7TQI3 P62259 OTUB1 YWHAE 0.081 16615898 Q7TQI3 P25233 OTUB1 NDN 0.183 22442722 Q7TQI3 Q62108 OTUB1 DLG4 0.236 19455133 Q7TQI3 P0CG50 OTUB1 UBC 0.21 26811477 Q7TQI3 Q62432 OTUB1 SMAD2 0.21 24071738 Q8BUN5 Q7TQI3 SMAD3 OTUB1 0.21 24071738 Q921E6 Q7TQI3 EED OTUB1 0.126 24457600 Q7TQI3 P48039 OTUB1 MTNR1A 0.126 26514267 Q7TQI3 P68510 OTUB1 YWHAH 0.126 21311561