PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Rybp Pcgf6 22325148 biogrid,intact exp Tfcp2l1 Pcgf6 20362541 biogrid,intact exp G G G G G G G G G G G G G G Nanog Pcgf6 23892456 biogrid,intact exp Max Pcgf6 20946988 i2d,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eed Pcgf6 24457600 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G L3mbtl2 Pcgf6 22770845 biogrid exp, ortho Cbx7 Pcgf6 22325148 biogrid,intact exp, ortho G G G G G G G G G G G G G G G G Pcgf6 Rnf2 17296600,22496869 biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Zbtb33 Pcgf6 ortho Tfdp1 Pcgf6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pcgf6 Prkab1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eftud1 Pcgf6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tulp3 Pcgf6 ortho G G G G G G G G G G G G G G G G G G G G G G G G Cep170b Pcgf6 ortho Ss18l1 Pcgf6 ortho Pnma1 Pcgf6 ortho Pcgf6 Usp21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx3 Pcgf6 ortho G G G G Cdk7 Pcgf6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kdm5d Pcgf6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Pcgf6 Cbx8 ortho G G G G G G G G G G G Usp2 Pcgf6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Rictor Pcgf6 ortho Pcgf6 Wbp2nl ortho Pcgf6 Rad18 ortho G G G G G G G Ube2u Pcgf6 ortho Pcgf6 Apbb1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Rpp38 Pcgf6 ortho Eif2b2 Pcgf6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ddx51 Pcgf6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pcgf6 Elp3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Pcgf6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Znf526 Pcgf6 ortho Wdr76 Pcgf6 ortho Pex10 Pcgf6 ortho Hsp90aa1 Pcgf6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E2f6 Pcgf6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cep78 Pcgf6 ortho Hsp90ab1 Pcgf6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mga Pcgf6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Auts2 Pcgf6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Wdr5 Pcgf6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mier2 Pcgf6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Pcgf6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Zkscan1 Pcgf6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psme3 Pcgf6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bmi1 Pcgf6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Elavl1 Pcgf6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hdac1 Pcgf6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pcgf6 Cbx6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q99NA9 A2RS90 affinity chromatography technology 23892456 physical association X 2 Q3UNW5 Q99NA9 affinity chromatography technology 20362541 physical association X 2 Q8CCI5 Q99NA9 affinity chromatography technology 22325148 physical association X 2 Q921E6 Q99NA9 affinity chromatography technology 24457600 physical association X 2 Q99NA9 Q9CQJ4 affinity chromatography technology 22496869 physical association X 2 Q99NA9 Q9CQJ4 affinity chromatography technology 17296600 physical association X 2 P59178 Q99NA9 affinity chromatography technology 22770845 physical association X 2 Q8VDS3 Q99NA9 affinity chromatography technology 22325148 physical association X 2 Q99NA9 anti tag coimmunoprecipitation 20362541 association C 93 Q99NA9 pull down 20946988 association C 17 Q99NA9 anti tag coimmunoprecipitation 23892456 association C 143 Q99NA9 pull down 17296600 association C 52 Q99NA9 anti tag coimmunoprecipitation 22325148 association C 4 Q99NA9 anti tag coimmunoprecipitation 22325148 association C 6

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Cbx7 Pcgf6 MI:0071(molecular sieving)|MI:0004(affinity chromatography technology) 22325148 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_174814|BIOGRID_320775 bait|bait prey|prey Pcgf6 Rnf2 MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology) 17296600,22496869 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0914(association)|MI:0915(physical association) (biogrid)|(intact)|(biogrid) BIOGRID_320479|UniProt_166511|BIOGRID_315711 prey|prey|prey bait|bait|bait Rybp Pcgf6 MI:0071(molecular sieving)|MI:0004(affinity chromatography technology) 22325148 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_174817|BIOGRID_320769 bait|bait prey|prey Tfcp2l1 Pcgf6 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 20362541 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association)|MI:0914(association) (intact)|(biogrid)|(intact) UniProt_170696|BIOGRID_314042|UniProt_107197 bait|bait|bait prey|prey|prey Eed Pcgf6 MI:0004(affinity chromatography technology) 24457600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_331775 bait prey Nanog Pcgf6 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 23892456 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_177306|BIOGRID_331310 bait|bait prey|prey L3mbtl2 Pcgf6 MI:0004(affinity chromatography technology) 22770845 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_328047 bait prey

PPI - HINT Gene A Gene B PMID Method Quality MAX PCGF6 20946988 0096 LC L3MBTL2 PCGF6 22770845 0004 LC TFCP2L1 PCGF6 20362541,20362541 0004,0007 LC NANOG PCGF6 23892456,23892456 0007,0004 LC RYBP PCGF6 22325148,22325148 0004,0007 LC CBX7 PCGF6 22325148,22325148 0004,0007 LC EED PCGF6 24457600 0004 LC PCGF6 RNF2 17296600,17296600,22496869 0096,0004,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q99NA9 P59178 PCGF6 L3MBTL2 0.21 22770845 Q99NA9 Q8VDS3 PCGF6 CBX7 0.236 22325148 Q99NA9 Q3UNW5 PCGF6 TFCP2L1 0.236 20362541 Q99NA9 Q80Z64 PCGF6 NANOG 0.236 23892456 Q99NA9 Q8CCI5 PCGF6 RYBP 0.236 22325148 Q9CQJ4 Q99NA9 RNF2 PCGF6 0.332 17296600,22496869 Q99NA9 Q921E6 PCGF6 EED 0.126 24457600 Q99NA9 P28574 PCGF6 MAX 0.126 20946988