PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Pkd2 Btrc 17636028 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stat1 Btrc 18378670 innatedb,biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Bhlhe41 23555304 intact exp G G G Tpx2 Btrc 24115035 biogrid exp G G G G G G G G G G G G G Cops2 Btrc 19576224 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nkx3-2 Btrc 21606193 biogrid exp Htt Btrc 20531388 biogrid,mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Reg1 Btrc 22037600 biogrid exp G G G G G G Gli2 Btrc 16611981 biogrid exp, ortho G G G G G Per1 Btrc 17462724 biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ikbkb Btrc 21606193 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Gsk3b 23555304 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fgd1 Btrc 15743413 innatedb exp, ortho G G G G G G G G G G G G G G G G Bcl2l11 Btrc 21151042 mint,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Cul1 10097128,23452855,11735228 innatedb,biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Nfkbia 15922723,10497169,10097128,10790373 innatedb,biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ctnnb1 Btrc 25873176 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nfkbie Btrc 10497169 innatedb exp, ortho G G G G Per2 Btrc 15767683,17462724 biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G Btrc Nfe2l2 21245377,22964642 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Wwtr1 17636028 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Csnk1e 23555304 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc25b Btrc 21807946 biogrid exp, ortho G G G G G G G G G G G G G G G Btrc Skp1 10097128,18929646,10514433,23452855,11735228 innatedb,biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Nfkb2 24115035 innatedb exp, ortho G G G G G G G G G G G G Btrc Nfkbib 10497169 innatedb exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ywhae Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Mrpl49 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Mrps18a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Skp2 ortho G G G G G G G G G G G G G Btrc Keap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Amer1 ortho Myb Btrc ortho G G G G G G G G G G G G G G G Btrc Ggnbp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Sirt2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Elmo2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tjp1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Ncor2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Ppp6c ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btg2 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mapk14 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd4 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Mrps31 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Dvl2 ortho G G G G G G G G G G G Btrc Stil ortho G G G Btrc Ddit4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hivep2 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Zc3h12a ortho G G G G G Btrc Dvl3 ortho Btrc Twistnb ortho Cct3 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc E2f1 ortho G G G G Btrc Apc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psma3 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Cep44 ortho Mcl1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Rab5a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Rassf3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Akt2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Mrpl40 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Fbxw11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Pdlim5 ortho G G G G G G G G G G G G Btrc Numb ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rela Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Ofd1 ortho G G G G G G G G G G G G G G G Hsp90ab1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Tcp11l2 ortho Gpatch8 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Ccdc22 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ikbkg Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Cnot1 ortho Faf1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dld Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc UPF0705 protein C11orf49 homolog ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Rgag1 Btrc ortho Btrc Dlgap5 ortho G G G G G G G G Btrc Cnot10 ortho Nedd8 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Uhrf1 ortho G G G G G G G G G G G G Btrc Mrpl4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Yap1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ywhag Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Chuk ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cul4a Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Krt79 ortho G G G G G Btrc Prrc2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Plk4 ortho G G G G G G G G G G G G G G G G G G Cdk1 Btrc ortho G G G G G G G G G G G G G G G G G G G G Oip5 Btrc ortho Btrc Nuak2 ortho Btrc Fnip1 ortho Protein Zfp395 Btrc ortho G G G G G G G G G G G Btrc Flcn ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Met Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G Btrc Maged1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ep300 Btrc ortho Btrc Mrpl15 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Nfe2l1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Pfdn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Bcl10 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Aldh2 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rap1gap Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Lrrc49 ortho G G G G G G G G G G Btrc Mrpl21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tp63 Btrc ortho G G G G G G Pfdn2 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Cep55 ortho G G G G G G G G G G G G Vbp1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Mrpl12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hsf1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Foxn2 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Emg1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Smg5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Zbtb46 ortho G G G G G G G G G G G G G G G Ghr Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Spata5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tafazzin, WW domain-containing transcription regulator protein 1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Cdc42bpa ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Nme7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prdx1 Btrc ortho Btrc Cnot11 ortho Rps18 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Mrps27 ortho Btrc Ogt ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Txnl1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Bag2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Alms1 ortho Btrc Clspn ortho Btrc Mrps35 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Ripk4 ortho G G G G G G G G G G G G G G G G Tp53 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Elf3 ortho G G G G G G G G G G G G G G G G G G G Btrc Wdr12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Ftmt ortho G Btrc Asf1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Aldh3a2 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Cp ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Hey2 ortho G G G Btrc Tiam1 ortho G G G G G G G G G G G G G G G G G G G G G G G G Igf2bp1 Btrc ortho G G Eif3a Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Hipk2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspb1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Sel1l ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Nxf1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dmd Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G Smad4 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Smg7 ortho Btrc Deptor ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Hpgds ortho G G G G G G Epor Btrc ortho G G G G G G G G G G G G G G G G Ddb1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Mdn1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Tubgcp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnrc6a Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Cry2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Protein Rbmxl2 ortho Axin2 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G Btrc Fbxw8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Ssx2ip ortho G G G G G G G G G G G G G G G G G G G G Cct4 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Fam219a ortho Btrc Erbb2ip ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mark3 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Cltc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Rcan1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Abcd3 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Map2k1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Ezh2 ortho G G G G G G G G G G G G G G G G G G G G G G Btrc Tsc22d4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Nol10 ortho Btrc Usp37 ortho Btrc Lrrc47 ortho Btrc Bub1b ortho G G G G G G G G G G G G Cry1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Ago2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Tbk1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dvl1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Axin1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tspan15 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Prlr Btrc ortho G G G G G G G G G G G G G G G G G Dlg5 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G Btrc Hras ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sp1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnf Btrc ortho Btrc Nsfl1c ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Myc Btrc ortho G G G G G G G G G G G G G G G G G G G G Btrc Sun2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Trib2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Chpf ortho G G G G G G G G G G G G G G G G G G G G G G G G Btrc Cdc20 ortho G G G G G G G G G G G G G G G G G G G G G Eef2k Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Map1s ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Usp54 ortho Jup Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct2 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Rassf1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Hcfc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Gm7694 Btrc ortho Cct5 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Mrpl37 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Pcm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Dap3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tchp Btrc ortho Btrc Cttn ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Mrps22 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mtr Btrc ortho Btrc Snrnp70 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bmi1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hnrnpul2 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dcp1b Btrc ortho Btrc Suz12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Afg3l2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kras Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mov10 Btrc ortho G G G G G G G G G G G G G G G G G G G Atp5g2 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Aldh1a2 ortho G G G G G G G G G G G G G G G G G G G G G Btrc Cpvl ortho Elavl1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Plch1 ortho G G G G G G G G G G G G G G G G G G G MCG129038, Protein Serpinb3a Btrc ortho Hnrnpk Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fgd3 Btrc ortho G G G G G Csnk2b Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Rapgef2 ortho Cct7 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Wwc1 ortho G G G G G G G G G G G G G G G G G G G G G Btrc Mrpl38 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Phlpp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Prkar1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Arih1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Rassf5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Stk3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Csnk1a1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Aebp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nfkb1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Mrpl41 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bhlhe40 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Mrps34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Tacc1 ortho Ckap5 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Akap2 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ice1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Sipa1l1 ortho Btrc Dlg1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cops4 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Crebrf ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d2 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Aurka Btrc ortho G G G G G G G G G G G G G G Btrc Bora ortho Btrc Smad3 ortho G G G G G G G G G G G G G G G Btrc Activator protein 4, Protein Tfap4, Transcription factor AP4 ortho G G G G G G Btrc Pitpnm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Mtss1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Mrpl44 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Irak1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Mrpl48 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sox9 Btrc ortho G G G G G G G G G G G G G G G G G Btrc Pdcd4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hsp90aa1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Rqcd1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nfe2 Btrc ortho G G G G Nudc Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Ubqln2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Il10ra ortho G G G G Col10a1 Btrc ortho Btrc Ppm1g ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Mrpl47 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Sufu ortho G G Nedd1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G Btrc Gli3 ortho Mdm2 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vcp Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Egflam ortho Pfdn6 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Wwox ortho G G G G G G G G G G G G G G G G G G G Btrc Ccne1 ortho G G G G G G G G Ufd1l Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Nrd1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Casp3 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Tbc1d4 ortho Kiaa1109 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Clu Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Clpx ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Rnf7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Exoc5 Btrc ortho Btrc Rest ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Terf1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Usp47 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Dpcd ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Kank2 ortho G G G G G G G G G G G G G G G G G G G G G Btrc Dact1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ccnd1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Foxo3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ywhaz Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkaca Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Nuak1 ortho Btrc Trim9 ortho Btrc Tnrc6b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d3 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Pfdn5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Acbd5 ortho Btrc Hnrnpc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Snai1 Btrc ortho G G G Btrc Ube4b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Golgi-specific brefeldin A-resistance factor 1, Prostaglandin E synthase 2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Gopc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Pcdh8 ortho G G G G G G Gli1 Btrc ortho G G G Btrc Hnrnpu ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct6a Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Tpgs1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atf4 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Acss2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btg1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Dbn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Dcp1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Ube2r2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rel Btrc ortho G G G G Tubgcp3 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hivep1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bop1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Vcpip1 ortho Btrc Nr1h2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Hnrnpab ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mast3 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Ywhab ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Ythdf3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Smurf1 ortho Btrc Cep68 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rps10 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Prefoldin subunit 4 ortho Ctnna1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ifnar1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Pttg1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc25a Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Aatf ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wee1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Mast2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Hnrnpd ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Dock1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Aktip ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ccdc138 Btrc ortho Btrc Stk4 ortho G G G G G G Btrc Usmg5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smurf2 Btrc ortho Btrc Cand1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Fbxo5 ortho Wbp1 Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc E2f5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Mrpl24 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Btrc Znf704 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q3ULA2 anti tag coimmunoprecipitation 17462724 association C 3 Q3ULA2 Q9UMX1 pull down 10564661 direct interaction X 2 Q3ULA2 P42859 anti bait coimmunoprecipitation 20531388 physical association X 2 Q3ULA2 O54918 anti bait coimmunoprecipitation 21151042 physical association X 2 Q3ULA2 Q16537 two hybrid 23555304 physical association X 2 Q3ULA2 Q9JMK2 two hybrid 23555304 physical association X 2 Q3ULA2 A0A024R7J0 two hybrid 23555304 physical association X 2 Q3ULA2 Q9WV60 two hybrid 23555304 physical association X 2 Q3ULA2 anti tag coimmunoprecipitation 23452855 association C 3 Q3ULA2 Q99PV5 two hybrid 23555304 physical association X 2 Q3ULA2 A0A024RBP2 two hybrid 23555304 physical association X 2 Q3ULA2 P30154 two hybrid 23555304 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Btrc Bhlhe41 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 23555304 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_184714|UniProt_128369|UniProt_176244 prey|prey|prey bait|bait|bait Btrc Taz MI:0004(affinity chromatography technology) 17636028 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_328192 prey bait Btrc Nfe2l2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21245377,22964642 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_316050|BIOGRID_316051|BIOGRID_323005|BIOGRID_323003|BIOGRID_316216|BIOGRID_323002 prey|bait|bait|prey|bait|bait bait|prey|prey|bait|prey|prey Per1 Btrc MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 17462724 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_321804|UniProt_166404 prey|prey bait|bait Nkx3-2 Btrc MI:0004(affinity chromatography technology) 21606193 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_316534 bait prey Per2 Btrc MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15767683,17462724 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid) UniProt_166404|BIOGRID_327888|BIOGRID_321805 prey|bait|prey bait|prey|bait Htt Btrc MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 20531388 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|MI:0471(mint) UniProt_171098|BIOGRID_321780|BIOGRID_321779|MINT_79371 bait|bait|prey|bait prey|prey|bait|prey Btrc Gsk3b MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 23555304 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_184791|UniProt_128446|UniProt_176321 bait|bait|bait prey|prey|prey Bcl2l11 Btrc MI:0006(anti bait coimmunoprecipitation) 21151042 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_173489 null prey Btrc Skp1 MI:0809(bimolecular fluorescence complementation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid) 10097128,11735228,18929646,23452855 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) UniProt_177027|BIOGRID_316068|BIOGRID_325909|BIOGRID_316066|BIOGRID_316065|BIOGRID_316069|BIOGRID_322240|BIOGRID_322239 bait|bait|bait|bait|prey|bait|bait|bait prey|prey|prey|prey|bait|prey|prey|prey Btrc Cul1 MI:0809(bimolecular fluorescence complementation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 10097128,11735228,23452855 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid) UniProt_177027|BIOGRID_316067|BIOGRID_325904 bait|bait|bait prey|prey|prey Cops2 Btrc MI:0004(affinity chromatography technology) 19576224 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_319733 bait prey Btrc Csnk1e MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 23555304 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_176288|UniProt_184758|UniProt_128413 prey|prey|prey bait|bait|bait Btrc Tpx2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 24115035 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_331719|BIOGRID_331720 prey|bait bait|prey Gli2 Btrc MI:0096(pull down)|MI:0096(pull down) 16611981 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_315948|BIOGRID_315949 bait|prey prey|bait Reg1 Btrc MI:0004(affinity chromatography technology) 22037600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_326138 bait prey Cdc25b Btrc MI:0004(affinity chromatography technology) 21807946 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_316162 prey bait Btrc Nfkbia MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 10097128 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_319603|BIOGRID_316071|BIOGRID_316070 bait|prey|bait prey|bait|prey Ikbkb Btrc MI:0004(affinity chromatography technology) 21606193 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_316533 bait prey

PPI - HINT Gene A Gene B PMID Method Quality PKD2 BTRC 17636028,17636028 0004,0415 LC CDC25B BTRC 21807946 0415 LC BTRC NFE2L2 21245377,22964642,22964642,21245377 0415,0004,0018,0004 LC BTRC BHLHE41 23555304 0018 LC BTRC CSNK1E 23555304 0018 LC BTRC SKP1 10097128,10097128,18929646,18929646,10097128 0018,0004,0004,0018,0096 LC BTRC GSK3B 23555304 0018 LC BTRC NFKBIA 10097128,10097128 0415,0004 LC TPX2 BTRC 24115035 0004 LC PKD2 BTRC 17636028,17636028 0004,0415 LC PER1 BTRC 17462724,17462724 0004,0007 LC BCL2L11 BTRC 21151042 0006 LC PER2 BTRC 17462724 0007 LC IKBKB BTRC 21606193 0004 LC STAT1 BTRC 18378670 0004 LC HTT BTRC 20531388,20531388 0006,0004 LC GADD45A BTRC 26022109,26022109 0004,0096 LC COPS2 BTRC 19576224 0004 LC SMAD4 BTRC 26022109 0004 LC NKX3-2 BTRC 21606193 0004 LC CTNNB1 BTRC 25873176 0006 LC GLI2 BTRC 16611981,16611981 0004,0096 LC REG1 BTRC 22037600 0004 LC BTRC NFE2L2 21245377,22964642,22964642,21245377 0415,0004,0018,0004 LC BTRC Q8C8R0 15767683,17462724 0004,0004 LC BTRC WWTR1 17636028 0004 LC BTRC SKP1 10097128,23452855,10097128,18929646,18929646,10097128,11735228 0018,0007,0004,0004,0018,0096,0004 LC BTRC CUL1 11735228,23452855,10097128 0004,0007,0004 LC BTRC NFKBIA 10790373,10097128,10097128 0004,0415,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q3ULA2 P61202 BTRC COPS2 0.21 19576224 Q3ULA2 O54943 BTRC PER2 0.507 17462724,15767683 Q9JMK2 Q3ULA2 CSNK1E BTRC 0.183 23555304 Q9WTX5 Q3ULA2 SKP1 BTRC 0.899 10097128,18929646,23452855,11735228 Q9WV60 Q3ULA2 GSK3B BTRC 0.183 23555304 Q3ULA2 P0CG63 BTRC UBI4 0.309 21070969 Q3ULA2 O88351 BTRC IKBKB 0.21 21606193 Q9Z1E3 Q3ULA2 NFKBIA BTRC 0.659 10790373,10097128 Q3ULA2 O35973 BTRC PER1 0.376 17462724 Q60795 Q3ULA2 NFE2L2 BTRC 0.837 21245377,22964642 Q9WTX6 Q3ULA2 CUL1 BTRC 0.507 11735228,10097128,23452855 Q3ULA2 P30154 BTRC PPP2R1B 0.183 23555304 Q99PV5 Q3ULA2 BHLHE41 BTRC 0.183 23555304 Q9EPK5 Q3ULA2 WWTR1 BTRC 0.21 17636028 Q3ULA2 P43137 BTRC REG1 0.21 22037600 Q3ULA2 P17612 BTRC PRKACA 0.183 23555304 Q3ULA2 P48316 BTRC GADD45A 0.454 26022109 Q3ULA2 P97503 BTRC NKX3-2 0.21 21606193 Q3ULA2 P49768 BTRC PSEN1 0.126 27036734 Q3ULA2 A2APB8 BTRC TPX2 0.376 24115035 Q3ULA2 O35245 BTRC PKD2 0.454 17636028 Q3ULA2 O54918 BTRC BCL2L11 0.21 21151042 Q3ULA2 P30306 BTRC CDC25B 0.309 21807946 Q3ULA2 P36873 BTRC PPP1CC 0.183 23555304 Q3ULA2 P42859 BTRC HTT 0.21 20531388 Q3ULA2 P97471 BTRC SMAD4 0.21 26022109 Q3ULA2 Q02248 BTRC CTNNB1 0.21 25873176 Q3ULA2 Q0VGT2 BTRC GLI2 0.454 16611981 Q3ULA2 Q16537 BTRC PPP2R5E 0.183 23555304 Q9UGI0 Q3ULA2 ZRANB1 BTRC 0.21 18281465 Q9UMX1 Q3ULA2 SUFU BTRC 0.309 10564661 Q9Z301 Q3ULA2 PER2 BTRC 0.376 18782782