PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ube3a Ywhae 16615898 intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Prdx1 24295341 biogrid exp, ortho P Ube3a Pml 19325566 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G Ube3a Herc2 21493713 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Arc ortho G G G G G Ube3a Golga3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Hpcal4 ortho Ube3a Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Txnl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Tbc1d14 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Sgk223 ortho Ube3a Hspa4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a UPF0705 protein C11orf49 homolog ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Hsf1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a WD repeat and coiled-coil-containing protein C2orf44 homolog ortho Ube3a Xrcc6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Ube2d3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Tcf19 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Ube2l3 ortho P Ube3a Tsc2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Yod1 ortho Ube3a Phka2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Srprb ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Rad23b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Lpp ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Scamp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Jade1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Ddx39b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Rnf2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Blk ortho G G G G G Ube3a Mycbp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Rara ortho G G Ube3a Dr1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Ubqln1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Arntl2 ortho G Ube3a Phkb ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Unc45a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Meox2 ortho G G G G G G G G G G Ube3a Ndufa13 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Ube2e1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Trim65 ortho Ube3a Ube3a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Rad23a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Myh9 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Tnpo3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Ube2v1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Nr3c1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Psmd3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Eapp ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Psmc3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Arpc1b ortho P Ube3a Anxa1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Sod1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Hspa8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Cebpa ortho G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Bard1 ortho Ube3a Atg9a ortho Ube3a Nelfcd ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Eif4g1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Scrib ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Tat ortho G G G G G G Ube3a Pole4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Anxa2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Ubc ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Arntl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Ube2d1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Esr2 Ube3a ortho G Ube3a Psmc1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Usp14 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Sf3b3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Nploc4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Arhgef15 ortho Ube3a Acta1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Neurl4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Mettl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Ect2 ortho G G G G G G G G G G G G G Ube3a Parva ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Ar ortho G G G G G G G G G G G G G G G G Ube3a Mcm7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Smad9 ortho Ube3a Plaur ortho G G G G G G G G G G G G G G G G G G G Ube3a Lepre1 ortho G G G G G G G G G G G G G Ube3a Lck ortho G G G G G G G G G G G G G G Ube3a Phkg2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Cdkn1b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Lsm5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Brca1 ortho G G G G G G G G G G G G G Ube3a Ube2g2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Srsf9 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Aftph ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Phkg1 ortho GP G G G Ube3a Ywhaz ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Ipo11 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Esr1 ortho G G G G G Ube3a Faf2 ortho P Ube3a Ppp5c ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Hif1an ortho Ube3a Mapk6 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Shfm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Uchl5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Dbnl ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Lrsam1 ortho P Ube3a Ntrk1 ortho Ube3a Cebpz ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Ufd1l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ptpn3 Ube3a ortho Ube3a Psap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Eid1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Ncoa3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Cftr ortho G G G G G G G G Ube3a Klhl38 ortho Ube3a App ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Ubqln2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Pgr ortho G Ube3a Rmi1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Ttc3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Sumo3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Btf3l4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Dlg1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bak1 Ube3a ortho G G G G G G G G G G G G G G G G G Ube3a Ube2l6 ortho G G G G G G G G G Ube3a Shbg ortho G G Ube3a Asap3 ortho Ube3a Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Ube2d2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Ube2g1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Psmd4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Tp53 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Psmd14 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Aspm ortho G G G G G G G G G G G G G G Ube3a Lsm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Trpv5 ortho Ube3a Pde1b ortho G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O08759 P62837 pull down 9182527 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality UBE3A YWHAE 16615898 0027 LC UBE3A PRDX1 24295341 0428 LC UBE3A HERC2 21493713 0004 LC UBE3A PML 19325566 0004 LC UBE3A ATXN3 18201976 0004 LC