PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Bach1 Smad5 16101586 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bach1 Smad9 16101586 biogrid exp Smad1 Bach1 16101586 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ywhae Bach1 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bach1 Ncor1 19011633 dip exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bach1 Mafk 19011633 i2d,dip exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tp53 Bach1 19011633 dip exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Bach1 Bach1 20211142 biogrid,i2d exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hdac1 Bach1 19011633 dip exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bach1 Hmmr 19011633 dip exp, ortho G G G G G G G G G G G G G Mafg Bach1 19011633 i2d,dip exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bach1 Xpo1 15175654 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bach1 Protein Patz1, Transcription factor MAZR, Zinc finger protein 278, isoform CRA_d i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Taf4b Bach1 ortho Nlk Bach1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bach1 Csnk1a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bach1 Ptbp3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bach1 Creb5 ortho Maf Bach1 ortho G Bach1 Nbn ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bach1 Palb2 ortho Kiaa1429 Bach1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ddit3 Bach1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bach1 Pphln1 ortho Mafb Bach1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Bach1 Rbck1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bach1 Fbxl17 ortho Crem Bach1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Tbc1d10a Bach1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Batf Bach1 ortho G G G G G G G G G G Bach1 Topbp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bach1 Fam83d ortho Bach1 Atf7 ortho G G G G G G G G G G G Bach1 Anapc5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fos Bach1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mov10 Bach1 ortho G G G G G G G G G G G G G G G G G G G Bach1 Mlh1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bach1 Tmem208 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atf2 Bach1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Brca1 Bach1 ortho G G G G G G G G G G G G Bach1 Mre11a ortho G G G G G G G G G G G G G G G G G G G G G G G G Bard1 Bach1 ortho Bach1 Creb1 ortho GP G G G G G G G G G G G G G G G G G G G G G Bach1 Park2 ortho G G G Bach1 Ddx39b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bach1 Nxf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bach1 Brca2 ortho G G G G G G G G G G G G G G G G G G G G Bach1 Pabpn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Maff Bach1 ortho G G G G G G G Brcc3 Bach1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bach1 Smad3 ortho G G G G G G G G G G G G G G G Bach1 Nfe2l2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bach1 Plrg1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bach1 Serine hydroxymethyltransferase ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P97302 P97302 - 8887638 - X 2 Q9JMG9 P97302 - 10669750 - X 2 O54790 P97302 - 8887638 - X 2 P97302 Q61827 - 8887638 - X 2 P97302 Q61827 - 8887638 - X 2 P97302 Q61827 - 8887638 - X 2 O75330-3 P97302 affinity chromatography technology 20360068 physical association X 2 Q9ULX9 P97302 affinity chromatography technology 20360068 physical association X 2 A0A024R8X1 P97302 affinity chromatography technology 20360068 physical association X 2 P63167 P97302 affinity chromatography technology 20360068 physical association X 2 O14867 P97302 affinity chromatography technology 20360068 physical association X 2 P97302 affinity chromatography technology 20360068 physical association X 2 P97302 P97302 two hybrid 20211142 direct interaction X 2 Q9JIW5 P97302 affinity chromatography technology 16101586 physical association X 2 P97454 P97302 affinity chromatography technology 16101586 physical association X 2 P97302 A0A024R0Y6 affinity chromatography technology 20360068 physical association X 2 P97302 A0A024R3Q3 affinity chromatography technology 20360068 physical association X 2 A0A024R804 P97302 affinity chromatography technology 20360068 physical association X 2 P70340 P97302 affinity chromatography technology 16101586 physical association X 2 Q6P5F9 P97302 pull down 15175654 direct interaction X 2 P97302 anti tag coimmunoprecipitation 19011633 - C 5 P97302 anti tag coimmunoprecipitation 19011633 - C 5 O09106 P97302 anti tag coimmunoprecipitation 19011633 physical association X 2 O09106 P97302 anti tag coimmunoprecipitation 19011633 physical association X 2 P97302 anti tag coimmunoprecipitation 19011633 - C 5 P97302 anti bait coimmunoprecipitation 19011633 - C 5 P97302 anti tag coimmunoprecipitation 19011633 - C 5 Q549C9 P97302 anti tag coimmunoprecipitation 19011633 physical association X 2 Q549C9 P97302 anti bait coimmunoprecipitation 19011633 physical association X 2 Q549C9 P97302 anti tag coimmunoprecipitation 19011633 physical association X 2 Q549C9 P97302 anti bait coimmunoprecipitation 19011633 physical association X 2 O54790 P97302 anti tag coimmunoprecipitation 19011633 physical association X 2 O54790 P97302 anti tag coimmunoprecipitation 19011633 physical association X 2 P97302 Q61827 anti tag coimmunoprecipitation 19011633 direct interaction X 2 P97302 Q61827 anti tag coimmunoprecipitation 19011633 direct interaction X 2 P97302 Q61827 anti tag coimmunoprecipitation 19011633 direct interaction X 2 P97302 Q61827 anti tag coimmunoprecipitation 19011633 direct interaction X 2 P97302 Q61827 pull down 19011633 direct interaction X 2 Q00547 P97302 anti tag coimmunoprecipitation 19011633 physical association X 2 Q00547 P97302 anti tag coimmunoprecipitation 19011633 physical association X 2 Q60974 P97302 anti tag coimmunoprecipitation 19011633 physical association X 2 Q60974 P97302 anti tag coimmunoprecipitation 19011633 physical association X 2 Q60974 P97302 anti tag coimmunoprecipitation 19011633 physical association X 2 Q60974 P97302 anti tag coimmunoprecipitation 19011633 physical association X 2 P97302 tandem affinity purification 20360068 physical association C 10 Q9JMG9 P97302 copurification 10669750 - X 2 P97302 Q61827 two hybrid 8887638 - X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Tp53 Bach1 MI:0096(pull down)|MI:0096(pull down) 19011633 taxid:10090(Mus musculus) taxid:10090(Mus musculus) -|MI:0915(physical association) MI:0465(dip)|MI:0465(dip) DIP_614|DIP_613 -|- -|- Bach1 Xpo1 MI:0004(affinity chromatography technology) 15175654 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_316010 bait prey Smad1 Bach1 MI:0004(affinity chromatography technology) 16101586 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_320100 bait prey Hdac1 Bach1 MI:0096(pull down)|MI:0096(pull down) 19011633 taxid:10090(Mus musculus) taxid:10090(Mus musculus) -|MI:0915(physical association) MI:0465(dip)|MI:0465(dip) DIP_614|DIP_654 -|- -|- Bach1 Mafk MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 19011633 taxid:10090(Mus musculus) taxid:10090(Mus musculus) -|-|MI:0407(direct interaction) MI:0465(dip)|MI:0465(dip)|MI:0465(dip) DIP_615|DIP_614|DIP_612 -|-|- -|-|- Mafg Bach1 MI:0096(pull down)|MI:0096(pull down) 19011633 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|- MI:0465(dip)|MI:0465(dip) DIP_658|DIP_615 -|- -|- Bach1 Hmmr MI:0096(pull down)|MI:0096(pull down) 19011633 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|- MI:0465(dip)|MI:0465(dip) DIP_659|DIP_615 -|- -|- Bach1 Ncor1 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 19011633 taxid:10090(Mus musculus) taxid:10090(Mus musculus) -|-|MI:0915(physical association) MI:0465(dip)|MI:0465(dip)|MI:0465(dip) DIP_615|DIP_614|DIP_653 -|-|- -|-|- Bach1 Smad5 MI:0004(affinity chromatography technology) 16101586 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_320107 prey bait Bach1 Smad9 MI:0004(affinity chromatography technology) 16101586 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_320114 prey bait

PPI - HINT Gene A Gene B PMID Method Quality MAFG BACH1 8887638 0018 LC YWHAE BACH1 16615898 0027 LC BACH1 BACH1 20211142,8887638 0018,0018 HT,LC BACH1 MAFK 8887638 0018 LC HDAC1 BACH1 19011633 0007 LC MAFG BACH1 19011633 0007 LC HBB-B2 BACH1 19966288 0007 LC TP53 BACH1 19011633,19011633 0006,0007 LC SMAD1 BACH1 16101586 0004 LC BACH1 SMAD5 16101586 0004 LC BACH1 HMMR 19011633 0007 LC BACH1 NCOR1 19011633 0007 LC BACH1 MAFK 19011633,19011633 0096,0007 LC BACH1 XPO1 15175654 0096 LC BACH1 SMAD9 16101586 0004 LC BACH1 PATZ1 10669750 0025 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P97302 P62259 BACH1 YWHAE 0.081 16615898 P97302 O54790 BACH1 MAFG 0.033 19011633 Q9JIW5 P97302 SMAD9 BACH1 0.21 16101586 P97302 O60333 BACH1 KIF1B 0.236 26496610 P97302 O15061 BACH1 SYNM 0.236 26496610 P97302 O14867 BACH1 BACH1 0.236 20360068 Q86VR2 P97302 FAM134C BACH1 0.236 26496610 P97302 P61204 BACH1 ARF3 0.236 20360068 P97302 P07686 BACH1 HEXB 0.236 26496610 P97302 P55011 BACH1 SLC12A2 0.236 26496610 P97302 P09001 BACH1 MRPL3 0.236 26496610 P97302 P53804 BACH1 TTC3 0.236 26496610 Q86TI2 P97302 DPP9 BACH1 0.236 26496610 P97302 P84077 BACH1 ARF1 0.236 20360068 P97302 P63167 BACH1 DYNLL1 0.236 20360068 Q6PII3 P97302 CCDC174 BACH1 0.236 26496610 Q13162 P97302 PRDX4 BACH1 0.236 26496610 Q5RHP9 P97302 ERICH3 BACH1 0.236 26496610 Q9H9T3 P97302 ELP3 BACH1 0.236 26496610 Q9H0U3 P97302 MAGT1 BACH1 0.236 26496610 Q61827 P97302 MAFK BACH1 0.332 19011633 P97302 P02340 BACH1 TP53 0.261 19011633 P97302 O60675 BACH1 MAFK 0.416 26496610,20360068 P97302 O15525 BACH1 MAFG 0.416 26496610,20360068 P97302 O75330 BACH1 HMMR 0.416 26496610,20360068 Q9H4H8 P97302 FAM83D BACH1 0.416 26496610,20360068 Q9ULX9 P97302 MAFF BACH1 0.416 26496610,20360068 P97302 P70340 BACH1 SMAD1 0.21 16101586 P97302 P97302 BACH1 BACH1 0.21 20211142 Q00547 P97302 HMMR BACH1 0.033 19011633 Q60974 P97302 NCOR1 BACH1 0.033 19011633 Q6P5F9 P97302 XPO1 BACH1 0.309 15175654 P97454 P97302 SMAD5 BACH1 0.21 16101586 P97302 O09106 BACH1 HDAC1 0.033 19011633