PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ywhae Uimc1 16615898 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Uba52 Uimc1 19536136 mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Uimc1 Sumo3 17698038 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Uimc1 17698038 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2i Uimc1 17698038 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sumo1 Uimc1 17698038 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Uimc1 Serine hydroxymethyltransferase ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G H2afx Uimc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rad23a Uimc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tp53 Uimc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Blm Uimc1 ortho G G G G G G Brca1 Uimc1 ortho G G G G G G G G G G G G G Uimc1 Skil ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cask Uimc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Fam175b Uimc1 ortho Cdk1 Uimc1 ortho G G G G G G G G G G G G G G G G G G G G G Uimc1 Dpy30 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Uimc1 Pycrl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Uimc1 Nr6a1 ortho G G G G Alb Uimc1 ortho G G G G G G G G G G G G G G G G G G G Uimc1 Protein Spata2, Spermatogenesis associated 2 ortho Uimc1 Wdr48 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Uimc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Capzb Uimc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Brcc3 Uimc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Uimc1 Dvl2 ortho G G G G G G G G G G G G Uimc1 Rbbp8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Uimc1 Thnsl1 ortho G G G G G G G G G G G G G G G G G G G Mdc1 Uimc1 ortho Uimc1 Erp44 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Uimc1 Bre ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ccna2 Uimc1 ortho G G G G G G G G G G G G G G G G G G G G Uimc1 Bag5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Uimc1 Fancg ortho G G G G G G G G G G G G G Babam1 Uimc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Uimc1 Nxf1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atp8a2 Uimc1 ortho G G G G G G G G G G3bp2 Uimc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Uimc1 Ecm29 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Uimc1 Fam175a ortho Uimc1 MCG2065, isoform CRA_c, PreS1 binding protein, Protein Gltscr2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rps6 Uimc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rad51 Uimc1 ortho G G G G G G G G G G G G G Uimc1 Hist2h2ac ortho Uimc1 Ino80b ortho G G G G G Uimc1 Dlst ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sumo2 Uimc1 ortho G3bp1 Uimc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Uimc1 Uba3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Uimc1 Hspa4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Uimc1 Rfc4 ortho G G G G G G G G G G G G G G G G G G G G C1qbp Uimc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Capza1 Uimc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Uimc1 Cpne1 ortho Uimc1 Hist1h2bc, Hist1h2be, Hist1h2bg ortho Uimc1 Uimc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Uimc1 Amot ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Bard1 Uimc1 ortho Esr1 Uimc1 ortho G G G G G Uimc1 Ssu72 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Uimc1 Nae1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mov10 Uimc1 ortho G G G G G G G G G G G G G G G G G G G G Uimc1 Cep57 ortho Uimc1 Nrd1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tp53bp1 Uimc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pfas Uimc1 ortho F7 Uimc1 ortho G G Lin7c Uimc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q5U5Q9 P62984 pull down 19536136 direct interaction X 2 Q5U5Q9 P62984 x-ray crystallography 19536136 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Ubc Uimc1 MI:0018(two hybrid) 17698038 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_322144 bait prey Ube2i Uimc1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0027(cosedimentation) 16615898,17698038 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0403(colocalization) (biogrid)|(biogrid)|(biogrid)|(intact) BIOGRID_322141|BIOGRID_322139|BIOGRID_322140|UniProt_167133 bait|prey|prey|neutral component prey|bait|bait|neutral component Sumo1 Uimc1 MI:0018(two hybrid) 17698038 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_322142 bait prey Ubb Uimc1 MI:0027(cosedimentation)|MI:0096(pull down)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0096(pull down) 10,16615898,19536136 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(intact)|MI:0471(mint)|MI:0471(mint)|(intact) UniProt_167133|UniProt_170969|MINT_77054|MINT_77053|UniProt_170971 neutral component|prey|prey|neutral component|neutral component neutral component|bait|bait|neutral component|neutral component Uimc1 Sumo3 MI:0027(cosedimentation)|MI:0018(two hybrid) 16615898,17698038 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0915(physical association) (intact)|(biogrid) UniProt_167133|BIOGRID_322143 neutral component|prey neutral component|bait

PPI - HINT Gene A Gene B PMID Method Quality UBC UIMC1 19536136,19536136 0114,0096 LC YWHAE UIMC1 16615898 0027 LC UBA52 UIMC1 19536136,19536136 0114,0096 LC UBE2I UIMC1 17698038,17698038,17698038 0096,0004,0018 LC UBC UIMC1 19536136,19536136,17698038 0114,0096,0004 LC UBA52 UIMC1 19536136,19536136 0114,0096 LC SUMO1 UIMC1 17698038 0004 LC UBE2I UIMC1 17698038,17698038,17698038 0096,0004,0018 LC UIMC1 SUMO3 17698038 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q5U5Q9 P62259 UIMC1 YWHAE 0.081 16615898 Q9Z172 Q5U5Q9 SUMO3 UIMC1 0.21 17698038 Q5U5Q9 P0CG50 UIMC1 UBC 0.21 17698038 Q5U5Q9 P62991 UIMC1 UBA52 0.523 19536136 Q5U5Q9 P63166 UIMC1 SUMO1 0.21 17698038 Q5U5Q9 P63280 UIMC1 UBE2I 0.623 17698038