PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ift20 Atg16l1 24089209 dip exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fadd Atg16l1 18946037 innatedb,biogrid,dip exp GP G G G G G G G G G G G G G G G G G G G G G G G G Gja1 Atg16l1 24705551 dip exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Grin1 Atg16l1 10862698,16635246 mint,intact exp G G G G G G G G Atg16l1 Map1lc3a 24553140 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Atg16l1 22167182 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg16l1 Atg16l1 12665549,23262492,18448665 innatedb,biogrid,dip exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rab35 Atg16l1 18448665 innatedb exp, ortho P Ulk1 Atg16l1 23262492 dip exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rab33b Atg16l1 18448665 innatedb,biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rab33a Atg16l1 18448665 innatedb exp, ortho G G G G G G G Atg16l1 Atg13 23262492 dip exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg16l1 Atg12 12665549 innatedb exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg16l1 Rb1cc1 23392225,23262492 intact,dip exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg16l1 Atg5 12665549,18448665 innatedb,biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cltc Atg16l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Atg16l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg16l1 Tmem59 ortho P G Ap2m1 Atg16l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tgfbr1 Atg16l1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Elavl1 Atg16l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct2 Atg16l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspa4 Atg16l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Exoc7 Atg16l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmc3 Atg16l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct3 Atg16l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg16l1 Gan ortho Htt Atg16l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Med13 Atg16l1 ortho P Prmt6 Atg16l1 ortho G G G G G G G G G Ntn1 Atg16l1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Atg16l1 Synpo2 ortho GP G G G G G G G G G Becn1 Atg16l1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg16l1 Mavs ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2r5e Atg16l1 ortho Gabarapl2 Atg16l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Snapc4 Atg16l1 ortho Flot2 Atg16l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg16l1 Nod2 ortho Atg16l1 Map1lc3b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Katnb1 Atg16l1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Casp6 Atg16l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Atg16l1 Dedd2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Agps Atg16l1 ortho P Atg16l1 Gabarap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Atg16l1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg16l1 Gabarapl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdk1 Atg16l1 ortho G G G G G G G G G G G G G G G G G G G G G Trmt2a Atg16l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Spc25 Atg16l1 ortho G G G G G G G G G G G G G G G G G G G Tecpr1 Atg16l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Spata5 Atg16l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wipi2 Atg16l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tufm Atg16l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdfy3 Atg16l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hnrnpa2b1 Atg16l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bmpr1b Atg16l1 ortho G G G Atg16l1 Ndufb5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg16l1 Nxf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg16l1 Tlr2 ortho G G G G G G G G G G G G G G G G G Nod1 Atg16l1 ortho App Atg16l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Casp3 Atg16l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg16l1 Atg101 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atg16l1 Atg3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fcgrt Atg16l1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ikbkg Atg16l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rab3d Atg16l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct7 Atg16l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Traf3ip3 Atg16l1 ortho Mov10 Atg16l1 ortho G G G G G G G G G G G G G G G G G G G G Atg16l1 Ftmt ortho G Xpo1 Atg16l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Casp1 Atg16l1 ortho GP G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8C0J2 coimmunoprecipitation 12665549 association C 3 Q8C0J2 affinity chromatography technology 12665549 association C 3 Q8C0J2 mass spectrometry studies of complexes 12665549 association C 3 Q8C0J2 two hybrid 12665549 association C 3 Q8C0J2 tandem affinity purification 18946037 - C 5 Q61025 Q8C0J2 anti bait coimmunoprecipitation 24089209 physical association X 2 Q61025 Q8C0J2 anti bait coimmunoprecipitation 24089209 physical association X 2 Q8TDY2 Q8C0J2 pull down 23262492 direct interaction X 2 Q8TDY2 Q8C0J2 pull down 23262492 direct interaction X 2 Q8TDY2 Q8C0J2 pull down 23262492 direct interaction X 2 Q8TDY2 Q8C0J2 pull down 23262492 direct interaction X 2 Q8TDY2 Q8C0J2 anti bait coimmunoprecipitation 23262492 direct interaction X 2 Q8TDY2 Q8C0J2 anti tag coimmunoprecipitation 23262492 direct interaction X 2 A9UGY9 Q8C0J2 pull down 23262492 physical association X 2 A9UGY9 Q8C0J2 pull down 23262492 physical association X 2 Q8C0J2 Q8C0J2 pull down 23262492 physical association Y 1 Q8C0J2 O75143 pull down 23262492 physical association X 2 Q8C0J2 P23242 anti bait coimmunoprecipitation 24705551 physical association X 2 Q8C0J2 P23242 anti tag coimmunoprecipitation 24705551 physical association X 2 Q8C0J2 pull down 23262492 - C 3 Q8C0J2 anti tag coimmunoprecipitation 23262492 - C 3 Q8C0J2 pull down 23262492 - C 3 Q8C0J2 pull down 23262492 - C 4 Q91YI1 Q8C0J2 pull down 23262492 physical association X 2 Q9ESK9 Q8C0J2 pull down 23262492 physical association X 2 Q9ESK9 Q8C0J2 tandem affinity purification 23262492 physical association X 2 Q9ESK9 Q8C0J2 pull down 23262492 physical association X 2 Q9ESK9 Q8C0J2 anti bait coimmunoprecipitation 23262492 physical association X 2 Q61160 Q8C0J2 tandem affinity purification 18946037 physical association X 2 Q8C0J2 pull down 23262492 physical association X 2 Q8C0J2 anti bait coimmunoprecipitation 16635246 association C 38 Q8C0J2 cross-linking study 23392225 association C 3 Q8C0J2 Q91VR7 fluorescence microscopy 24553140 colocalization X 2 Q8C0J2 fluorescence microscopy 19590496 colocalization C 3 Q9ESK9 Q8C0J2 cross-linking study 23392225 physical association X 2 Q9ESK9 Q8C0J2 two hybrid 23392225 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Grin1 Atg16l1 MI:0029(cosedimentation through density gradient)|MI:0019(coimmunoprecipitation) 10862698,16635246 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association) (intact)|MI:0471(mint) UniProt_166355|MINT_58070 bait|bait prey|prey Sqstm1 Atg16l1 MI:0004(affinity chromatography technology) 22167182 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_320621 bait prey Atg16l1 Atg5 MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0676(tandem affinity purification) 12665549,18946037 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|- (biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0465(dip) BIOGRID_325847|BIOGRID_325851|BIOGRID_325848|BIOGRID_325850|DIP_641 prey|bait|prey|prey|- bait|prey|bait|bait|- Rab33b Atg16l1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18448665 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_322936|BIOGRID_322939 bait|bait prey|prey Fadd Atg16l1 MI:0676(tandem affinity purification)|MI:0676(tandem affinity purification) 18946037 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|- MI:0465(dip)|MI:0465(dip) DIP_666|DIP_641 -|- -|- Atg16l1 Rb1cc1 MI:0030(cross-linking study)|MI:0030(cross-linking study)|MI:0030(cross-linking study) 23392225 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0914(association) (intact)|(intact)|(intact) UniProt_175720|UniProt_175719|UniProt_175721 prey|bait|prey bait|prey|bait

PPI - HINT Gene A Gene B PMID Method Quality GRIN1 ATG16L1 10862698 0019 LC ATG16L1 ATG16L1 12665549,12665549,12665549 0007,0004,0018 LC ATG16L1 MAP1LC3A 24553140 0416 LC ATG16L1 ATG5 12665549,12665549,12665549,12665549,12665549 0004,0007,0428,0018,0663 LC ATG16L1 RB1CC1 23392225,23392225 0030,0018 LC RAB33B ATG16L1 18448665,18448665,18448665 0004,0007,0096 LC ULK1 ATG16L1 23262492 0096 LC GJA1 ATG16L1 24705551,24705551 0007,0006 LC GRIN1 ATG16L1 16635246 0006 HT RAB33A ATG16L1 18448665 0096 LC IFT20 ATG16L1 24089209 0006 LC FADD ATG16L1 18946037,18946037 0004,0676 LC SQSTM1 ATG16L1 22167182 0004 LC RAB35 ATG16L1 18448665 0007 LC ATG16L1 ATG16L1 12665549,12665549,18448665,23262492,12665549 0007,0004,0007,0096,0018 LC ATG16L1 ATG13 23262492 0096 LC ATG16L1 ATG5 12665549,12665549,12665549,12665549,12665549,18448665 0004,0007,0428,0018,0663,0007 LC ATG16L1 RB1CC1 23262492,23262492,23262492 0676,0006,0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8C0J2 Q64337 ATG16L1 SQSTM1 0.21 22167182 Q8C0J2 O35963 ATG16L1 RAB33B 0.21 18448665 Q8C0J2 O94817 ATG16L1 ATG12 0.21 12665549 Q8NCE2 Q8C0J2 MTMR14 ATG16L1 0.126 19590496 Q9ESK9 Q8C0J2 RB1CC1 ATG16L1 0.569 23392225 Q9GZQ8 Q8C0J2 MAP1LC3B ATG16L1 0.126 19590496 Q8C0J2 Q61160 ATG16L1 FADD 0.236 18946037 Q99J83 Q8C0J2 ATG5 ATG16L1 0.858 12665549 Q8C0J2 Q8C0J2 ATG16L1 ATG16L1 0.74 12665549 Q8C0J2 P36897 ATG16L1 TGFBR1 0.126 15761153 Q91VR7 Q8C0J2 MAP1LC3A ATG16L1 0.126 24553140 Q8C0J2 P35438 ATG16L1 GRIN1 0.126 16635246 Q8C0J2 O00238 ATG16L1 BMPR1B 0.126 15761153