PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Hdac4 Myocd 15601857 biogrid exp Htt Hdac4 24302884 dip exp Gli2 Hdac4 22549777 biogrid exp Tnf Hdac4 16260608 biogrid exp Creb1 Hdac4 22466704 biogrid exp Ncf4 Hdac4 15102471 intact exp Hdac4 Nars 15102471 intact exp Stat3 Hdac4 18065416 innatedb exp Hdac4 Foxo1 21565616 intact exp Gja1 Hdac4 21282606 dip exp Hdac4 Rfxank 16236793 biogrid exp, ortho Dnajb6 Hdac4 16260608 innatedb,biogrid exp, ortho Hdac3 Hdac4 19498465 intact exp, ortho Mef2a Hdac4 10737771,22466704 biogrid exp, ortho Ppp2ca Hdac4 22466704 biogrid exp, ortho Hdac4 Mef2c 10737771 biogrid exp, ortho Ifrd1 Hdac4 15743821 biogrid exp, ortho Hdac4 Ywhab 10958686,17923476 biogrid exp, ortho Runx2 Hdac4 15537544 biogrid,i2d,intact exp, ortho Mef2d Hdac4 10737771,19498465 biogrid,mint,intact exp, ortho Cdr2 Hdac4 ortho Ywhah Hdac4 ortho Mapk3 Hdac4 ortho Gnb1 Hdac4 ortho Hdac4 Hdac9 ortho Hdac4 Protein Tnfrsf14, Tumor necrosis factor receptor superfamily member 14 ortho Klf6 Hdac4 ortho Hdac4 Bub1b ortho Hif1a Hdac4 ortho MCG3834, Protein Zbtb16, Zinc finger and BTB domain containing 16 Hdac4 ortho Hdac4 Sirt1 ortho Jdp2 Hdac4 ortho Cbx5 Hdac4 ortho Hdac4 Nup214 ortho Sin3a Hdac4 ortho Ppp2r4 Hdac4 ortho Hdac4 Lcor ortho Hdac1 Hdac4 ortho Hnf4a Hdac4 ortho Hdac4 Dhx36 ortho Ncor1 Hdac4 ortho Hdac4 Ruvbl2 ortho Hdac4 Ss18l1 ortho Hdac4 Efemp2 ortho Sumo1 Hdac4 ortho Znf148 Hdac4 ortho Mapk1 Hdac4 ortho Pparg Hdac4 ortho Ar Hdac4 ortho Hdac4 Camk1 ortho Hdac4 Pnma1 ortho Hdac4 Ldoc1 ortho Stat1 Hdac4 ortho Cdk5 Hdac4 ortho Ube2i Hdac4 ortho Hdac4 Srf ortho Ikzf1 Hdac4 ortho Hdac4 Ankra2 ortho Camk4 Hdac4 ortho Hdac4 Kdm5b ortho Hdac4 Golga2 ortho Krt40 Hdac4 ortho Sp1 Hdac4 ortho Nfkb1 Hdac4 ortho Acta1 Hdac4 ortho Hdac4 Mecom ortho Hdac4 Hdac5 ortho Hdac4 Brms1 ortho Rbbp4 Hdac4 ortho Bcorl1 Hdac4 ortho Hdac4 Nfkb2 ortho Cdkn1a Hdac4 ortho Ctnnb1 Hdac4 ortho Hdac4 Smad3 ortho Suv39h1 Hdac4 ortho Ahrr Hdac4 ortho Hdac4 Smarcb1 ortho Tp53bp1 Hdac4 ortho Rara Hdac4 ortho Gata1 Hdac4 ortho Hdac4 Ikzf4 ortho Hira Hdac4 ortho Hdac4 Hic1 ortho Syk Hdac4 ortho Protein Ankrd11 Hdac4 ortho Sumo2 Hdac4 ortho Mtus2 Hdac4 ortho Atf3 Hdac4 ortho Hdac4 Park2 ortho Hdac4 Bcor ortho Zbtb7b Hdac4 ortho Ciita Hdac4 ortho Ikzf2 Hdac4 ortho Hist1h4a, Hist1h4b, Hist1h4c, Hist1h4d, Hist1h4f, Hist1h4h, Hist1h4i, Hist1h4j, Hist1h4k, Hist1h4m, Hist2h4a, Hist4h4 Hdac4 ortho Prg2 Hdac4 ortho Hdac4 Nfkbia ortho Nfkbie Hdac4 ortho Atxn1 Hdac4 ortho Nfatc1 Hdac4 ortho Atrx Hdac4 ortho Ywhae Hdac4 ortho Hdac4 Myef2 ortho Hdac4 Camk2d ortho Znf354a Hdac4 ortho Ikzf3 Hdac4 ortho Hdac4 Nup155 ortho Hdac4 Nacc1 ortho Nr1h2 Hdac4 ortho Hdac4 Map1s ortho Hdac4 Rint1 ortho Ppard Hdac4 ortho Ywhaz Hdac4 ortho Hdac4 Rest ortho Gcm1 Hdac4 ortho Gata3 Hdac4 ortho Hdac4 Rfxap ortho Hdac4 Esco2 ortho Hdac4 Foxp3 ortho Hdac4 Hdac7 ortho Mif4gd Hdac4 ortho Rxra Hdac4 ortho Rev3l Hdac4 ortho Ctbp1 Hdac4 ortho Megf10 Hdac4 ortho Dnajb5 Hdac4 ortho Bcl6 Hdac4 ortho Hdac4 Ppp2r1a ortho Cebpd Hdac4 ortho Hdac4 Cul7 ortho Esr1 Hdac4 ortho Ccdc136 Hdac4 ortho Csrp3 Hdac4 ortho Cacna1c Hdac4 ortho Ywhag Hdac4 ortho Senp1 Hdac4 ortho Elavl1 Hdac4 ortho Hdac4 Gsk3b ortho Runx3 Hdac4 ortho Nr2c1 Hdac4 ortho Hdac4 Tbl1xr1 ortho Hdac4 Zeb2 ortho Hdac4 Hdac4 ortho Yy1 Hdac4 ortho Mark3 Hdac4 ortho Hdac4 Mef2bnb ortho Sfn Hdac4 ortho Hdac4 Ncor2 ortho Tpd52 Hdac4 ortho Hdac4 Lztr1 ortho Cebpb Hdac4 ortho Atf2 Hdac4 ortho Morc2a Hdac4 ortho Nr2c2 Hdac4 ortho App Hdac4 ortho Hdac4 Dnajb8 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q08775-2 Q6NZM9 - 15537544 - X 2 Q6NZM9 Q8VIM5-5 affinity chromatography technology 15601857 physical association X 2 Q6NZM9 Q543F0 affinity chromatography technology 16236793 physical association X 2 Q6NZM9 Q543F0 affinity chromatography technology 16236793 physical association X 2 Q0VGT2 Q6NZM9 affinity chromatography technology 22549777 physical association X 2 P63330 Q6NZM9 affinity chromatography technology 22466704 physical association X 2 P63330 Q6NZM9 affinity chromatography technology 22466704 physical association X 2 P19182 Q6NZM9 affinity chromatography technology 15743821 physical association X 2 P19182 Q6NZM9 affinity chromatography technology 15743821 physical association X 2 Q60929 Q6NZM9 affinity chromatography technology 22466704 physical association X 2 Q60929 Q6NZM9 affinity chromatography technology 10737771 physical association X 2 P06804 Q6NZM9 affinity chromatography technology 16260608 physical association X 2 Q6NZM9 Q01147 affinity chromatography technology 22466704 physical association X 2 Q6NZM9 Q08775-9 affinity chromatography technology 15537544 physical association X 2 Q6NZM9 Q08775-9 affinity chromatography technology 15537544 physical association X 2 Q6NZM9 affinity chromatography technology 16260608 physical association X 2 Q6NZM9 affinity chromatography technology 16260608 physical association X 2 Q6NZM9 affinity chromatography technology 10737771 physical association X 2 Q6NZM9 Q921S6 affinity chromatography technology 10737771 physical association X 2 Q9CQV8 Q6NZM9 affinity chromatography technology 10958686 physical association X 2 Q9CQV8 Q6NZM9 affinity chromatography technology 17923476 physical association X 2 Q6NZM9 two hybrid 16221676 association C 3 Q6NZM9 coimmunoprecipitation 16221676 association C 3 Q6NZM9 P23242 anti bait coimmunoprecipitation 21282606 physical association X 2 Q6NZM9 P23242 anti bait coimmunoprecipitation 21282606 physical association X 2 Q6NZM9 pull down 24302884 direct interaction X 2 Q6NZM9 anti bait coimmunoprecipitation 21282606 - C 3 P42859 Q6NZM9 anti bait coimmunoprecipitation 24302884 physical association X 2 Q9R1E0 Q6NZM9 anti bait coimmunoprecipitation 21565616 physical association X 2 P97369 Q6NZM9 two hybrid 15102471 physical association X 2 Q63943 Q6NZM9 anti bait coimmunoprecipitation 19498465 association X 2 Q6NZM9 anti bait coimmunoprecipitation 19498465 association C 3 Q6NZM9 anti bait coimmunoprecipitation 19498465 association C 3 Q08775 Q6NZM9 anti tag coimmunoprecipitation 15537544 physical association X 2 Q08775 Q6NZM9 anti tag coimmunoprecipitation 15537544 physical association X 2 Q6NZM9 Q8BP47 two hybrid 15102471 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Hdac4 Rfxank MI:0018(two hybrid)|MI:0018(two hybrid) 16236793 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_327871|BIOGRID_327870 prey|bait bait|prey Creb1 Hdac4 MI:0004(affinity chromatography technology) 22466704 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_320568 prey bait Tnf Hdac4 MI:0004(affinity chromatography technology) 16260608 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_325627 prey bait Hdac4 Myocd MI:0004(affinity chromatography technology) 15601857 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_324460 bait prey Mef2a Hdac4 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 10737771,22466704 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_327859|BIOGRID_320567 prey|prey bait|bait Hdac4 Mef2c MI:0004(affinity chromatography technology) 10737771 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_327861 bait prey Gli2 Hdac4 MI:0004(affinity chromatography technology) 22549777 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_320436 bait prey Dnajb6 Hdac4 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16260608 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_325623|BIOGRID_325622 bait|prey prey|bait Ppp2ca Hdac4 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22466704 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_320570|BIOGRID_320571 prey|bait bait|prey Mef2d Hdac4 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology) 10,10737771,19498465 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0914(association)|MI:0915(physical association) (intact)|MI:0471(mint)|(biogrid) UniProt_171032|MINT_71949|BIOGRID_327863 bait|bait|prey prey|prey|bait Hdac4 Ywhab MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 10958686,17923476 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_315456|BIOGRID_315281 bait|bait prey|prey Ncf4 Hdac4 MI:0018(two hybrid) 15102471 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_164739 prey bait Ifrd1 Hdac4 MI:0096(pull down)|MI:0096(pull down) 15743821 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_315032|BIOGRID_315033 prey|bait bait|prey Runx2 Hdac4 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 15537544 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact)|(intact) BIOGRID_325395|BIOGRID_325394|UniProt_163998|UniProt_163999 bait|prey|bait|prey prey|bait|prey|bait Hdac4 Foxo1 MI:0007(anti tag coimmunoprecipitation) 21565616 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_172473 prey bait Hdac4 Nars MI:0018(two hybrid) 15102471 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_164740 bait prey Atm Hdac4 MI:0004(affinity chromatography technology) 22466704 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0796(suppressive genetic interaction defined by inequality) (biogrid) BIOGRID_320572 prey bait

PPI - HINT Gene A Gene B PMID Method Quality NCF4 HDAC4 15102471 0018 LC HDAC4 NARS 15102471 0018 LC DNAJB6 HDAC4 16260608 0004 LC HDAC3 HDAC4 19498465 0006 LC TNF HDAC4 16260608 0004 LC IFRD1 HDAC4 15743821 0004 LC GJA1 HDAC4 21282606 0006 LC HTT HDAC4 24302884 0006 LC PPP2CA HDAC4 22466704 0004 LC CREB1 HDAC4 22466704 0004 LC RUNX2 HDAC4 15537544,15537544 0007,0004 LC GLI2 HDAC4 22549777 0004 LC MEF2A HDAC4 22466704,10737771 0004,0004 LC MEF2D HDAC4 19498465,10737771 0006,0004 LC HDAC4 MEF2C 10737771 0004 LC HDAC4 MYOCD 15601857 0004 LC HDAC4 YWHAB 10958686,17923476 0004,0004 LC HDAC4 FOXO1 21565616 0006 LC HDAC4 RFXANK 16236793 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q6NZM9 Q0VGT2 HDAC4 GLI2 0.21 22549777 Q6NZM9 O54946 HDAC4 DNAJB6 0.376 16260608 Q9Z205 Q6NZM9 RFXANK HDAC4 0.376 16236793 Q6NZM9 Q63943 HDAC4 MEF2D 0.376 19498465,10737771 Q6NZM9 O88895 HDAC4 HDAC3 0.21 19498465 Q8VIM5 Q6NZM9 MYOCD HDAC4 0.21 15601857 Q6NZM9 P06804 HDAC4 TNF 0.21 16260608 Q6NZM9 Q01147 HDAC4 CREB1 0.21 22466704 Q8CFN5 Q6NZM9 MEF2C HDAC4 0.21 10737771 Q8BP47 Q6NZM9 NARS HDAC4 0.183 15102471 Q6NZM9 Q08775 HDAC4 RUNX2 0.61 15537544 Q6NZM9 Q60929 HDAC4 MEF2A 0.376 10737771,22466704 Q9CQV8 Q6NZM9 YWHAB HDAC4 0.376 17923476,10958686 Q9R1E0 Q6NZM9 FOXO1 HDAC4 0.21 21565616 Q6NZM9 P97369 HDAC4 NCF4 0.183 15102471 Q6NZM9 P19182 HDAC4 IFRD1 0.376 15743821 Q6NZM9 P63330 HDAC4 PPP2CA 0.376 22466704