PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Nfe2 Rbbp5 17707229 biogrid exp Nanog Rbbp5 23892456 biogrid,intact exp Rbbp5 Rnf2 17296600,22496869 biogrid exp Esrrb Rbbp5 20362541 biogrid exp Rbbp5 Foxp3 22922362 biogrid exp Pax5 Rbbp5 21552207 mint,intact exp Ywhae Rbbp5 16615898 intact exp Phf20 Rbbp5 23452852 biogrid,intact exp Tfcp2l1 Rbbp5 20362541 intact exp Pou5f1 Rbbp5 22083510,23452852 biogrid,intact exp Rbbp5 Dpy30 21335234 intact exp, ortho Kmt2a Rbbp5 21335234 intact exp, ortho Wdr5 Rbbp5 21477851,21448134,21335234,17825402 biogrid,intact exp, ortho Rbbp5 Ash2l 17707229,21477851,21448134,21335234,17825402 biogrid,intact exp, ortho Kmt2d Rbbp5 24368734,17707229 biogrid exp, ortho Kdm6b Rbbp5 17825402 intact exp, ortho Cul4a Rbbp5 ortho Ube2i Rbbp5 ortho Rbbp5 Cxxc1 ortho Wdr82 Rbbp5 ortho Smarce1 Rbbp5 ortho Rbbp5 Ogt ortho Rbbp5 Tbk1 ortho Rbbp5 Wdr33 ortho Ep300 Rbbp5 ortho Myb Rbbp5 ortho Rbbp5 Kdm4b ortho DEAH (Asp-Glu-Ala-His) box polypeptide 38, Protein Dhx38 Rbbp5 ortho Esr1 Rbbp5 ortho Rbbp5 Srrt ortho Hist1h3b, Hist1h3c, Hist1h3d, Hist1h3e, Hist1h3f, Hist2h3b, Hist2h3c1, Hist2h3c2 Rbbp5 ortho Usf1 Rbbp5 ortho Rbbp5 Senp3 ortho Foxq1 Rbbp5 ortho Lsm2 Rbbp5 ortho Rbbp5 Gspt1 ortho Rbbp5 Cdc73 ortho Rbbp5 Pagr1a ortho Rbbp5 Wdr5b ortho Rbbp5 Dohh ortho Kdm6a Rbbp5 ortho Ctbp1 Rbbp5 ortho Rrm2 Rbbp5 ortho Ddb1 Rbbp5 ortho Foxk2 Rbbp5 ortho Rpl23a Rbbp5 ortho Klc2 Rbbp5 ortho Smarcd1 Rbbp5 ortho Rb1 Rbbp5 ortho Ascl2 Rbbp5 ortho Tuba1a Rbbp5 ortho Mef2d Rbbp5 ortho Cdk2 Rbbp5 ortho Kansl1 Rbbp5 ortho Was Rbbp5 ortho Atp5a1 Rbbp5 ortho Rbbp5 Kat8 ortho Cul4b Rbbp5 ortho Men1 Rbbp5 ortho Myh7b Rbbp5 ortho Tp53 Rbbp5 ortho Zbtb8os Rbbp5 ortho Psma3 Rbbp5 ortho Elavl1 Rbbp5 ortho Kmt2b Rbbp5 ortho Protein Pygo2, Pygopus 2 Rbbp5 ortho Cdc5l Rbbp5 ortho Rbbp5 Vps36 ortho Pparg Rbbp5 ortho Hcfc1 Rbbp5 ortho Ctnnb1 Rbbp5 ortho Smarcc1 Rbbp5 ortho Rbbp5 Hcfc2 ortho Chd8 Rbbp5 ortho Rbbp5 Snw1 ortho Protein Bod1l Rbbp5 ortho Rbbp5 Rbbp5 ortho Rbbp5 Ccar2 ortho Znf335 Rbbp5 ortho Pkn1 Rbbp5 ortho Rbbp5 Fermt3 ortho Emsy Rbbp5 ortho Rbbp5 Smarcd2 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8BX09 affinity chromatography technology 17707229 physical association X 2 Q8BX09 affinity chromatography technology 22083510 physical association X 2 Q8BX09 Q53Z59 affinity chromatography technology 22922362 physical association X 2 Q8BX09 P61965 affinity chromatography technology 17825402 physical association X 2 Q8BX09 A2RS90 affinity chromatography technology 23892456 physical association X 2 Q8BX09 Q9CQJ4 affinity chromatography technology 22496869 physical association X 2 Q8BX09 Q3UKZ9 affinity chromatography technology 17825402 physical association X 2 Q8BX09 Q8BLG0 affinity chromatography technology 23452852 physical association X 2 Q8BX09 affinity chromatography technology 24368734 physical association X 2 Q8BX09 affinity chromatography technology 20362541 physical association X 2 Q8BX09 Q9CQJ4 affinity chromatography technology 17296600 physical association X 2 Q8BX09 affinity chromatography technology 17707229 physical association X 2 Q8BX09 Q3UKZ9 affinity chromatography technology 17707229 physical association X 2 Q8BX09 anti bait coimmunoprecipitation 21335234 association C 5 Q8BX09 anti bait coimmunoprecipitation 21448134 association C 3 Q8BX09 anti bait coimmunoprecipitation 17825402 association C 3 Q8BX09 anti tag coimmunoprecipitation 23892456 association C 143 Q8BX09 anti tag coimmunoprecipitation 21477851 physical association C 4 Q8BX09 molecular sieving 21477851 physical association C 4 Q8BX09 anti bait coimmunoprecipitation 21448134 association C 3 Q02650 Q8BX09 anti bait coimmunoprecipitation 21552207 physical association X 2 Q91X20 Q8BX09 anti bait coimmunoprecipitation 17825402 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Nfe2 Rbbp5 MI:0004(affinity chromatography technology) 17707229 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_316300 bait prey Nanog Rbbp5 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 23892456 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_177306|BIOGRID_331328 bait|bait prey|prey Rbbp5 Ash2l MI:0006(anti bait coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0071(molecular sieving)|MI:0006(anti bait coimmunoprecipitation) 17707229,17825402,21335234,21448134,21477851 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association) (intact)|(intact)|(intact)|(biogrid)|(biogrid)|(intact)|(intact) UniProt_172875|UniProt_168222|UniProt_168223|BIOGRID_316307|BIOGRID_327215|UniProt_172152|UniProt_173554 bait|bait|bait|prey|bait|neutral component|prey prey|prey|prey|bait|prey|neutral component|bait Pax5 Rbbp5 MI:0006(anti bait coimmunoprecipitation) 21552207 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_173298 prey bait Rbbp5 Foxp3 MI:0004(affinity chromatography technology) 22922362 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_324846 prey bait Rbbp5 Rnf2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17296600,22496869 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_315687|BIOGRID_320506 prey|prey bait|bait Pou5f1 Rbbp5 MI:0071(molecular sieving)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 20362541,21477851,22083510 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association) (intact)|(biogrid)|(intact)|(intact) UniProt_172152|BIOGRID_320992|UniProt_170698|UniProt_107199 neutral component|bait|bait|bait neutral component|prey|prey|prey Mll2 Rbbp5 MI:0004(affinity chromatography technology) 17707229 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_316293 bait prey Esrrb Rbbp5 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 20362541 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0914(association)|MI:0914(association) (biogrid)|(intact)|(intact) BIOGRID_314160|UniProt_170698|UniProt_107199 bait|bait|bait prey|prey|prey Wdr5 Rbbp5 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0004(affinity chromatography technology)|MI:0027(cosedimentation) 16615898,17825402,21335234,21448134,21477851 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization) (intact)|(intact)|(intact)|(intact)|(biogrid)|(intact) UniProt_173553|UniProt_172875|UniProt_172154|UniProt_172152|BIOGRID_327214|UniProt_167114 bait|prey|bait|neutral component|prey|neutral component prey|bait|prey|neutral component|bait|neutral component Phf20 Rbbp5 MI:0004(affinity chromatography technology) 23452852 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_327332 prey bait

PPI - HINT Gene A Gene B PMID Method Quality WDR5 RBBP5 20716525 0114 LC YWHAE RBBP5 16615898 0027 LC RBBP5 ASH2L 21477851 0071 LC POU5F1 RBBP5 22083510 0004 LC KMT2A RBBP5 21335234 0006 LC WDR5 RBBP5 17500065,21448134,17825402,21335234,21477851 0006,0006,0004,0006,0007 LC PAX5 RBBP5 21552207 0006 LC NFE2 RBBP5 17707229 0004 LC TFCP2L1 RBBP5 20362541 0007 LC KDM6B RBBP5 17825402 0006 LC ESRRB RBBP5 20362541 0004 LC PAXIP1 RBBP5 17500065,17925232,26744420 0006,0006,0007 LC KMT2D RBBP5 24368734,17707229 0004,0004 LC NANOG RBBP5 23892456,23892456 0007,0004 LC PHF20 RBBP5 23452852,23452852 0004,0006 LC RBBP5 MAFA 26180087 0004 LC RBBP5 ASH2L 17500065,21448134,17707229,17825402,17825402,21335234 0006,0006,0004,0006,0004,0006 LC RBBP5 FOXP3 22922362 0004 LC RBBP5 DPY30 21335234 0006 LC RBBP5 RNF2 17296600,22496869 0004,0004 LC RBBP5 NCOA6 26180087 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8BX09 Q61539 RBBP5 ESRRB 0.126 20362541 Q8CF90 Q8BX09 MAFA RBBP5 0.21 26180087 Q8BX09 P62259 RBBP5 YWHAE 0.081 16615898 Q8BX09 Q8BLG0 RBBP5 PHF20 0.376 23452852 Q8BX09 P55200 RBBP5 KMT2A 0.21 21335234 Q8BX09 Q5NCY0 RBBP5 KDM6B 0.21 17825402 Q99LT0 Q8BX09 DPY30 RBBP5 0.21 21335234 Q9CQJ4 Q8BX09 RNF2 RBBP5 0.236 17296600,22496869 Q8BX09 Q80Z64 RBBP5 NANOG 0.236 23892456 Q8BX09 P61965 RBBP5 WDR5 0.61 21448134,17825402,21335234,21477851 Q91X20 Q8BX09 ASH2L RBBP5 0.808 17825402,21335234,17707229,21477851,21448134 Q99JB6 Q8BX09 FOXP3 RBBP5 0.126 22922362 Q8BX09 Q02650 RBBP5 PAX5 0.21 21552207 Q8BX09 P20263 RBBP5 POU5F1 0.126 22083510 Q8BX09 Q07279 RBBP5 NFE2 0.21 17707229 Q8BX09 Q3UNW5 RBBP5 TFCP2L1 0.126 20362541