PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ywhae Stam 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam Jak3 9133424 mint,intact exp G G G G G G G G G G G G G G G Stam Usp8 i2d exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam Jak2 9133424 mint,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ugdh Stam ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam Eps15l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Ppp1ca Stam ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam Snta1 ortho G G G G G G G G G G G G G G G G G G G G G G G Stam Tbck ortho Stam Trim63 ortho Stam Rffl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam Unk ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Stmn2 Stam ortho P G G G G G G G G G G G G G Stam Dtx3l ortho P Map3k1 Stam ortho G G G G G G G G G G G G G G G G G G G G G G G G G Stam Tle3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam Lcp2 ortho G G G G G G G G G G G G G G Stam Rab5a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sssca1 Stam ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam Arrb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam Tmem17 ortho Stam Ntrk1 ortho Ppp1cc Stam ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam Cltc ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Serpinh1 Stam ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam Ubqln4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MCG19772, Protein Trim55 Stam ortho Stam Sort1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam Igbp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G Stam Itch ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam Trim54 ortho G G G G G G G Stam Ppm1g ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam Gga1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam Tmem216 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam Usp28 ortho Stam Timm8a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam Prdx5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam Ywhab ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cops5 Stam ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam Pir ortho P Stam Sec31a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam Ahcyl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbf1 Stam ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam Hgs ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam Ubqln2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pja1 Stam ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam Stambp ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam Asap1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Stam ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Jak1 Stam ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam Cxcr4 ortho G G G G G G G G G G G Stam Usp34 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam Usp15 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam Egfr ortho GP G G G G G G G G G G G G G G G G G Stam2 Stam ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cd79b Stam ortho G G G G G G G G G G Stam Zpr1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cplx1 Stam ortho P G G G G G G G G G G G G G G G G G G G G Stam Plcb1 ortho GP G G G G G G G G G G Stam Itsn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Stam Med28 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Thada Stam ortho P Stam Stam ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P70297 Q80U87 - 10982817 - X 2 P70297 enzymatic study 25260751 direct interaction X 2 P70297 P0CG50 affinity chromatography technology 25260751 physical association X 2 P0CG48 P70297 pull down 12972556 direct interaction X 2 Q62137 P70297 coimmunoprecipitation 9133424 phosphorylation reaction X 2 O95630 P70297 pull down 10982817 direct interaction X 2 P70297 Q62120 coimmunoprecipitation 9133424 phosphorylation reaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Stam Jak2 MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation) 9133424 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0217(phosphorylation reaction)|MI:0217(phosphorylation reaction) (intact)|MI:0471(mint) UniProt_177655|MINT_85768 prey|prey bait|bait Stam Jak3 MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation) 9133424 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0217(phosphorylation reaction)|MI:0217(phosphorylation reaction) MI:0471(mint)|(intact) MINT_85657|UniProt_177654 prey|prey bait|bait

PPI - HINT Gene A Gene B PMID Method Quality YWHAE STAM 16615898 0027 LC STAM JAK2 9133424 0019 LC STAM JAK3 9133424 0019 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P70297 P62259 STAM YWHAE 0.081 16615898 P70297 P0CG48 STAM UBC 0.309 12972556 P70297 O95630 STAM STAMBP 0.309 10982817 Q62120 P70297 JAK2 STAM 0.033 9133424 Q62137 P70297 JAK3 STAM 0.033 9133424