PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Anapc2 Fbxo43 25161877 biogrid exp Invs Anapc2 12471060 biogrid exp G G G G G G G G G G G G G G G G G G G G G Anapc2 Cdc20 22084091 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G Cdc27 Anapc2 ortho G G G G G G Magix Anapc2 ortho G G G G Cdc5l Anapc2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lyar Anapc2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gria1 Anapc2 ortho G G G G G G G G Ufd1l Anapc2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc5 Anapc2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d2 Anapc2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hsp90aa1 Anapc2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sox2 Anapc2 ortho G G G G G G G G G G G Mageb4 Anapc2 ortho Tp53bp1 Anapc2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ep300 Anapc2 ortho P Usp7 Anapc2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc2 Ist1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc2 Bub1b ortho G G G G G G G G G G G G Anapc2 Rnf34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Epha4 Anapc2 ortho G G G G G G G G Anapc2 Cdc26 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc2 Ttll1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxo2 Anapc2 ortho P G G G G G G G G G G Ninl Anapc2 ortho Anapc2 Med19 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Phf8 Anapc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc2 Ube2c ortho G G G G G G G G G G G G G G G G G G Rb1 Anapc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc2 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc2 Anapc16 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smad2 Anapc2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Anapc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Grap2 Anapc2 ortho Anapc2 Pttg1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc2 Ube2s ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hsp90ab1 Anapc2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Crebbp Anapc2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc1 Anapc2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc23 Anapc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc2 Anapc7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pstpip1 Anapc2 ortho G G G G G G G G G Smarcad1 Anapc2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam2 Anapc2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc2 Anapc10 ortho Anapc2 Anapc11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc2 Anapc4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc2 Cdc16 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Slc35g1 Anapc2 ortho Cops5 Anapc2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc2 Mad2l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdc1 Anapc2 ortho P Fbxo5 Anapc2 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8BZQ7 affinity chromatography technology 25161877 physical association X 2 Q8BZQ7 x-ray crystallography 25161877 association X 2 Q8BZQ7 O89019 affinity chromatography technology 12471060 physical association X 2 Q8BZQ7 O89019 two hybrid 12471060 direct interaction X 2 Q8BZQ7 Q9UJX4-2 affinity chromatography technology 20360068 physical association X 2 Q8BZQ7 Q9UJX2 affinity chromatography technology 20360068 physical association X 2 Q8BZQ7 Q9UM13 affinity chromatography technology 20360068 physical association X 2 Q8BZQ7 Q13042-2 affinity chromatography technology 20360068 physical association X 2 Q8BZQ7 A0A024R832 affinity chromatography technology 20360068 physical association X 2 Q8BZQ7 affinity chromatography technology 20360068 physical association X 2 Q9H1A4 Q8BZQ7 affinity chromatography technology 20360068 physical association X 2 Q12834 Q8BZQ7 affinity chromatography technology 20360068 physical association X 2 Q8BZQ7 Q9JJ66 affinity chromatography technology 22084091 physical association X 2 Q8BZQ7 Q9UJX6 affinity chromatography technology 20360068 physical association X 2 Q8BZQ7 affinity chromatography technology 20360068 physical association X 2 O60566 Q8BZQ7 affinity chromatography technology 20360068 physical association X 2 Q8BZQ7 coimmunoprecipitation 10318877 association C 9

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Anapc2 Cdc20 MI:0004(affinity chromatography technology) 22084091 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_325190 prey bait Invs Anapc2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 12471060 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_310905|BIOGRID_310906 prey|prey bait|bait

PPI - HINT Gene A Gene B PMID Method Quality INVS ANAPC2 12471060,12471060 0018,0004 LC ANAPC2 FBXO43 25161877,25161877 0114,0004 LC INVS ANAPC2 12471060,12471060 0018,0004 LC ANAPC2 FBXO43 25161877,25161877 0114,0004 LC ANAPC2 CDC20 22084091 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9JJ66 Q8BZQ7 CDC20 ANAPC2 0.21 22084091 Q8BZQ7 F5GXB9 ANAPC2 ANAPC15 {ECO:0000313|ENSEMBL:ENSP00000440380} 0.126 26496610 Q8BZQ7 G5EA36 ANAPC2 G5EA36 0.126 26496610 Q8BZQ7 P56381 ANAPC2 ATP5E 0.126 26496610 Q8BZQ7 P60006 ANAPC2 ANAPC15 0.126 26496610 Q8BZQ7 Q5VTU8 ANAPC2 ATP5EP2 0.126 26496610 Q9UJX6 Q8BZQ7 ANAPC2 ANAPC2 0.126 20360068 Q8BZQ7 O75052 ANAPC2 NOS1AP 0.236 26496610 Q96DE5 Q8BZQ7 ANAPC16 ANAPC2 0.236 26496610 Q8BZQ7 P38435 ANAPC2 GGCX 0.236 26496610 Q8BZQ7 P31350 ANAPC2 RRM2 0.236 26496610 Q8BZQ7 P49454 ANAPC2 CENPF 0.236 26496610 Q8BZQ7 P51955 ANAPC2 NEK2 0.236 26496610 Q96C36 Q8BZQ7 PYCR2 ANAPC2 0.236 26496610 Q8BZQ7 Q3T906 ANAPC2 GNPTAB 0.236 26496610 Q8BZQ7 Q13257 ANAPC2 MAD2L1 0.236 26496610 Q8BZQ7 Q13616 ANAPC2 CUL1 0.236 26496610 Q8WUH6 Q8BZQ7 TMEM263 ANAPC2 0.236 26496610 Q8BZQ7 Q6P1Q0 ANAPC2 LETMD1 0.236 26496610 Q9UM11 Q8BZQ7 FZR1 ANAPC2 0.236 26496610 Q9P2B7 Q8BZQ7 KIAA1430 ANAPC2 0.236 26496610 Q9C037 Q8BZQ7 TRIM4 ANAPC2 0.236 26496610 Q96L92 Q8BZQ7 SNX27 ANAPC2 0.236 26496610 Q9BS18 Q8BZQ7 ANAPC13 ANAPC2 0.236 26496610 Q9NU22 Q8BZQ7 MDN1 ANAPC2 0.236 26496610 Q9H799 Q8BZQ7 C5ORF42 ANAPC2 0.236 26496610 Q9UM00 Q8BZQ7 TMCO1 ANAPC2 0.236 26496610 Q9UJJ9 Q8BZQ7 GNPTG ANAPC2 0.236 26496610 Q9UKT4 Q8BZQ7 FBXO5 ANAPC2 0.236 26496610 Q9UJX5 Q8BZQ7 ANAPC4 ANAPC2 0.236 26496610 Q8BZQ7 O60566 ANAPC2 BUB1B 0.332 26496610,20360068 Q9UM13 Q8BZQ7 ANAPC10 ANAPC2 0.332 26496610,20360068 Q8BZQ7 P30260 ANAPC2 CDC27 0.332 26496610,20360068 Q8BZQ7 Q13042 ANAPC2 CDC16 0.332 26496610,20360068 Q8BZQ7 Q12834 ANAPC2 CDC20 0.332 26496610,20360068 Q8NHZ8 Q8BZQ7 CDC26 ANAPC2 0.332 26496610,20360068 Q9H1A4 Q8BZQ7 ANAPC1 ANAPC2 0.332 26496610,20360068 Q9UJX3 Q8BZQ7 ANAPC7 ANAPC2 0.332 26496610,20360068 Q9UJX2 Q8BZQ7 CDC23 ANAPC2 0.332 26496610,20360068 Q9UJX4 Q8BZQ7 ANAPC5 ANAPC2 0.332 26496610,20360068