PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ubr1 Use1 21816346 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Ubr1 12391316 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Sos1 15102471 mint,intact exp P G G G G G G G G G Ubr1 Trpm7 24855944 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Ndufa4l2 ortho Ubr1 Znf593 ortho P Ubr1 Adamts12 ortho Ubr1 Fgl1 ortho G G G Ubr1 Gadd45a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ptprs Ubr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Ubxn7 ortho P Ubr1 Nsfl1c ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Ubc ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Usp5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anxa3 Ubr1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Tac3 ortho G G G G G G Ubr1 Bmp7 ortho G G G G G G G G G Ubr1 Dnph1 ortho P G G G G G G G G G G G G G G Ubr1 Tgfb1 ortho G G G G G G G G G G G G G G G G G G G G G Ubr1 Lamtor3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Itm2b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Vcl ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Fos ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Dnajb11 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Dmtn ortho GP G G G G G G G G G G G G G G G G G G G G Ubr1 Nudt3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Xpo1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Ube2b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Faf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Lipt1 ortho GP G G G G G G G G G G G G G G G Ubr1 Cdc6 ortho G G G G G G G G Ubr1 Ldlrad4 ortho G Ubr1 Bcl2l1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Btbd2 Ubr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Scml4 ortho G G G G G G Ubr1 Ube2d1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Tirap ortho G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Cse1l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Spry2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Gsk3b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Uchl3 ortho P Ubr1 Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Cbx8 ortho G G G G G G G G G G G Ubr1 Arl15 ortho P Ubr1 Ccdc130 ortho G Ubr1 Faf2 ortho P Ubr1 Fth1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Pfas ortho P Ubr1 Atp6v1a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Arl3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Recql4 ortho G G G Ubr1 Cul2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Nxf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Lama4 ortho GP G G G G G G G G G G G G G G G G G Ubr1 Arl4d ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Shfm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Ube2z ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Ntrk1 ortho Ubr1 Mrm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr1 Nxph2 ortho Protein Serpinb9, SPI6, Serine (Or cysteine) peptidase inhibitor, clade B, member 9 Ubr1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O70481 O70481 pull down 12391316 direct interaction X 2 O70481 affinity chromatography technology 21816346 physical association X 2 Q12158 O70481 pull down 12391316 direct interaction X 2 O70481 Q62245 two hybrid 15102471 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Ubr1 Sos1 MI:0018(two hybrid) 15102471 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_163083 prey bait Ubr1 Use1 MI:0004(affinity chromatography technology) 21816346 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_316655 prey bait

PPI - HINT Gene A Gene B PMID Method Quality UBR1 SOS1 15102471 0018 LC UBR1 UBR1 12391316 0096 LC UBR1 TRPM7 24855944 0007 LC UBR1 USE1 21816346 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q12158 O70481 MCD1 UBR1 0.309 12391316 O70481 O70481 UBR1 UBR1 0.332 12391316 Q62245 O70481 SOS1 UBR1 0.183 15102471 Q923J1 O70481 TRPM7 UBR1 0.126 24855944 Q9CQ56 O70481 USE1 UBR1 0.21 21816346