PTM - CPLM Gene Name UniProt ID Type Position Code Itch Q8C863 Ubiquitination 393 K Itch Q8C863 Ubiquitination 66 K Itch Q8C863 Ubiquitination 192 K Itch Q8C863 Ubiquitination 311 K Itch Q8C863 Ubiquitination 407 K Itch Q8C863 Ubiquitination 439 K Itch Q8C863 Ubiquitination 474 K

PTM - dbPAF Gene Name UniProt ID Position Type Species Itch Q8C863 176 S Mus musculus(Mouse) Itch Q8C863 177 T Mus musculus(Mouse) Itch Q8C863 18 S Mus musculus(Mouse) Itch Q8C863 180 S Mus musculus(Mouse) Itch Q8C863 199 S Mus musculus(Mouse) Itch Q8C863 222 T Mus musculus(Mouse) Itch Q8C863 232 S Mus musculus(Mouse) Itch Q8C863 26 S Mus musculus(Mouse) Itch Q8C863 411 S Mus musculus(Mouse) Itch Q8C863 425 T Mus musculus(Mouse) Itch Q8C863 475 S Mus musculus(Mouse)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q8C863 S18-p Phosphorylation MGSLTMKsQLQITVI Q8C863 S26-p Phosphorylation QLQITVIsAKLKENK Q8C863 T177-p Phosphorylation RDDTRVStNGsEDPE Q8C863 S180-p Phosphorylation TRVStNGsEDPEVAA Q8C863 S199-p Phosphorylation kRANGNNsPSLSNGG Q8C863 T222-p Phosphorylation PSRPPPPtPRRPASV Q8C863 S232-p Phosphorylation RPASVNGsPSTNSDS Q8C863 S411-p Phosphorylation GWEkRTDsNGRVYFV Q8C863 T425-p Phosphorylation VNHNTRItQWEDPRS Q8C863 S475-p Phosphorylation IDPRTGksALDNGPQ Q8C863 K66-ub Ubiquitination NTNSPKWkQPLTVIV Q8C863 K192-ub Ubiquitination VAASGENkRANGNNs Q8C863 K311-ub Ubiquitination YYVDHVEkRTTWDRP Q8C863 K393-ub Ubiquitination LFATSQNkEFDPLGP Q8C863 K407-ub Ubiquitination PLPPGWEkRTDsNGR Q8C863 K439-ub Ubiquitination SQGQLNEkPLPEGWE Q8C863 K474-ub Ubiquitination YIDPRTGksALDNGP

PTM - dbPTM UniProt ID Position Code Type Resources References Q8C863 199 S Phosphorylation Swiss-Prot 1010711 16446428 Q8C863 222 T Phosphorylation Swiss-Prot 1010711 16446428 Q8C863 232 S Phosphorylation Swiss-Prot 1010711 16446428 Q8C863 199 S Phosphorylation PhosphoELM.10011 16446428 Q8C863 232 S Phosphorylation PhosphoELM.10011 16446428 Q8C863 222 T Phosphorylation PhosphoELM.10011 16446428 Q8C863 180 S Phosphorylation Phosphositeplus.1010730 20531401 Q8C863 199 S Phosphorylation Phosphositeplus.1010730 16446428 Q8C863 232 S Phosphorylation Phosphositeplus.1010730 16446428 Q8C863 411 S Phosphorylation Phosphositeplus.1010730 15971201;17437719 Q8C863 177 T Phosphorylation Phosphositeplus.1010730 20531401 Q8C863 222 T Phosphorylation Phosphositeplus.1010730 16446428 Q8C863 425 T Phosphorylation Phosphositeplus.1010730 15971201;17437719

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q8C863 222 T 16446428 MAPK8 LTP Phosphorylation Q8C863 232 S 16446428 MAPK8 LTP Phosphorylation Q8C863 199 S 16446428 MAPK8 LTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q8C863 199 Phosphoserine; by MAPK8 16446428 Q8C863 222 Phosphothreonine; by MAPK8 16446428 Q8C863 232 Phosphoserine; by MAPK8 16446428

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type Itch IPI00380162 S 180 RVSTNGpSEDPEVA phosphorylation Itch IPI00380162 T 177 DDTRVSpTNGSEDP phosphorylation