PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Tbl1xr1 Foxp3 22922362 biogrid exp Nanog Tbl1xr1 23892456 biogrid,intact exp Ywhae Tbl1xr1 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ncor1 Tbl1xr1 15695367 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tbl1xr1 Rnf2 17296600 biogrid,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sox2 Tbl1xr1 21532573 intact exp, ortho G G G G G G G G G G G Lin54 Tbl1xr1 ortho Notch1 Tbl1xr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Thra Tbl1xr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psma3 Tbl1xr1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smarcd3 Tbl1xr1 ortho G G G G G G G G G G G G G G G G G G G Ar Tbl1xr1 ortho G G G G G G G G G G G G G G G G Foxk2 Tbl1xr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smarcd1 Tbl1xr1 ortho G G G G G G G G G G G G G G G G G G G G G G G Tbl1xr1 Actl6a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tbl1xr1 Coro2a ortho G G G G G G G G G G G G G G G G G G G G G G Hdac1 Tbl1xr1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Thrb Tbl1xr1 ortho G G G G G G Tbl1xr1 Hdac5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ski Tbl1xr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tbl1xr1 Smarcb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tbl1xr1 Tsc22d4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tbl1xr1 Nhp2l1 ortho P Hist1h4a, Hist1h4b, Hist1h4c, Hist1h4d, Hist1h4f, Hist1h4h, Hist1h4i, Hist1h4j, Hist1h4k, Hist1h4m, Hist2h4a, Hist4h4 Tbl1xr1 ortho P G G G G G G G G G G G G G G Foxk1 Tbl1xr1 ortho P G G G Ctnnb1 Tbl1xr1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Emd Tbl1xr1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tbl1xr1 Tbl1x ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smarcc1 Tbl1xr1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Elavl1 Tbl1xr1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tbl1xr1 Smarcd2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tbl1xr1 Hdac7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d1 Tbl1xr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ntrk1 Tbl1xr1 ortho Tbl1xr1 Bcl3 ortho G G G G G G G G G G G G G G G G G G Tbl1xr1 G protein pathway suppressor 2, MCG22494, isoform CRA_b, Protein Gps2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Chd4 Tbl1xr1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rara Tbl1xr1 ortho G G Tbl1xr1 Cd2bp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tbl1xr1 Ppif ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Tbl1xr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tbl1xr1 Eif2a ortho P Abcf1 Tbl1xr1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ninl Tbl1xr1 ortho Xpo1 Tbl1xr1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc5l Tbl1xr1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Esr1 Tbl1xr1 ortho G G G G G Ttc29 Tbl1xr1 ortho Hdac3 Tbl1xr1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tbl1xr1 Snw1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kdm1a Tbl1xr1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sirt6 Tbl1xr1 ortho Tbl1xr1 Arl2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tbl1xr1 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hdac4 Tbl1xr1 ortho Ube2e3 Tbl1xr1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tbl1xr1 Fkbp6 ortho G Smarcc2 Tbl1xr1 ortho P Tbl1xr1 Qprt ortho G G G Smad7 Tbl1xr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Nanog Tbl1xr1 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 23892456 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_177306|BIOGRID_331321 bait|bait prey|prey Tbl1xr1 Rnf2 MI:0004(affinity chromatography technology)|MI:0027(cosedimentation)|MI:0096(pull down)|MI:0027(cosedimentation) 16615898,17296600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0403(colocalization)|MI:0914(association)|MI:0403(colocalization) (biogrid)|(intact)|(intact)|(intact) BIOGRID_315692|UniProt_167137|UniProt_166511|UniProt_167133 prey|neutral component|prey|neutral component bait|neutral component|prey|neutral component Tbl1xr1 Ncor1 MI:0004(affinity chromatography technology) 15695367 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_315052 prey bait Tbl1xr1 Foxp3 MI:0004(affinity chromatography technology) 22922362 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_324898 prey bait

PPI - HINT Gene A Gene B PMID Method Quality YWHAE TBL1XR1 16615898 0027 LC SOX2 TBL1XR1 21532573,21532573 0007,0006 LC NCOR1 TBL1XR1 15695367 0004 LC NANOG TBL1XR1 23892456,23892456 0007,0004 LC TBL1XR1 FOXP3 22922362 0004 LC TBL1XR1 RNF2 17296600,17296600 0096,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8BHJ5 P62259 TBL1XR1 YWHAE 0.081 16615898 Q9CQJ4 Q8BHJ5 RNF2 TBL1XR1 0.236 17296600 Q8BHJ5 Q60I23 TBL1XR1 SOX2 0.236 21532573 Q8BHJ5 Q80Z64 TBL1XR1 NANOG 0.236 23892456 Q99JB6 Q8BHJ5 FOXP3 TBL1XR1 0.126 22922362