PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Src Trpc2 16407161 dip exp G G G G G G G G G G G G G G Src Krt16 22529101 innatedb exp G G Src Krt5 22529101 innatedb exp G G G G G G G Src Grin1 10862698,16635246 biogrid,intact exp G G G G G G G Src Trpc5 16407161 dip exp G G G G Src Eno1 9013636,14739300 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G Nfatc1 Src 20037154 biogrid exp G G G G G G G G G G G G G G G G G G G Src Trpc1 16407161 dip exp G G G G G G G G G G G G G G Src Shc3 15716419 biogrid exp G G G G G S1pr1 Src 21102457 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G Src Csn2 10684249 biogrid exp G G G G G Src Cav3 8663016,14600260 biogrid exp G G Src Ngef i2d exp G G G G G G G G G G G G G G G G Src Enah 8861907 biogrid,i2d exp G G G G G G G G G G G G G G G G G G G G G G G G Src Shc2 15716419 biogrid exp Src Trpc4 16407161 dip exp G G G G G G Src Dvl2 19920076 biogrid exp G G G G G G G G G G Src Map1lc3b doi:10.1038/embor.2012.92,22138575,22732841 biogrid,mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G Src Krt6a 22529101 innatedb exp G G G G G Src Csf1r 17420256,18840695 biogrid,dip exp G G G G G G G G G G G G G G G G G G G G G G G G G Src Htr4 19661922 intact exp Diaph1 Src 18194650 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G Src Csf1 16267818 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G Src Dcc i2d exp G G G G Atxn2 Src 18602463 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G Src Krt17 22529101 innatedb exp G Src Grid2ip i2d exp G Src Skp2 20596523 biogrid exp G G G G G G G G G G G G Src Met 18194650 biogrid exp G G G G G G G G G G G G G G G G G G G G G Src Pik3c2a 10684249 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G Src Inpp5d 16601135 biogrid exp G G G G G G G G G G G G G G G G G G G Src Esr1 17921256 biogrid exp, ortho G G G Src Sh3bp1 i2d exp, ortho G G G G G G G G G G G G Src Stub1 21911421 innatedb exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Dab1 15062102 biogrid,i2d exp, ortho G G G G G G G G Src Traf6 12631284 innatedb exp, ortho G G G G G G G G G G G G G G G G G G Src Akt1 19122674 biogrid,dip exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Pdgfrb i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Ret doi:10.1038/embor.2012.92,22732841 mint,intact exp, ortho G G G G G G G G Dok2 Src 15831486 mint,intact exp, ortho G G G G G G G G G G Src Khdrbs1 10844001,15890643 biogrid,i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Tlr9 21911421 innatedb exp, ortho G Src Egfr 11274221 biogrid,i2d exp, ortho G G G G G G G G G G G G G G Src Ptk2b 11274221,14739300 biogrid,i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G Src Cbl 11804588,9013636,8849724,8635998,17420256,22138575 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Ywhab 16635246 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Adam12 i2d exp, ortho G G G G G G G G G Src Ptk2 10931187,18233957 i2d,mint,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G Src Ywhae 16615898 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Pxn 14636584,16478788 biogrid,i2d,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Stat3 9582023,9154828 innatedb exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Evl i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G Src Pdcd6ip 15557335 i2d,mint,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Efnb2 i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G Src Ptpra 7518772 mint,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Insr 19122674 biogrid,dip exp, ortho G Src Ephb2 16298995 intact exp, ortho G G G G G G G G G G G G Src Sos1 i2d exp, ortho G G G G G G G G Itgb3 Src 17353363,18840695 innatedb,dip exp, ortho G Src Prkce 11139474,11834516 biogrid,i2d,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Adrb3 11013230 innatedb exp, ortho G G G G G G G Src Syk 17353363 innatedb exp, ortho G G G G G G G G G G G G G G G Src Dnm1 16319076 mint exp, ortho G G G G G G G G G G G G G G G G G G Src Sh3bp2 20439986,22153076 innatedb,biogrid exp, ortho G G G G G G G G G G G G G Src Krt14 22529101 innatedb exp, ortho G G G G G G Src Arrb2 19122674 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G Src Efnb1 i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Was 18289379 intact exp, ortho G G G G G G G G G Src Efs 8647432 biogrid exp, ortho G G G G G G G G G G G G G G G G G G Src Gja1 21282606 dip exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Srcin1 19146815 intact exp, ortho Src Tlr4 21911421 innatedb exp, ortho G G G G G G G G G G G G G G G G Adam15 Src i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Bcar1 i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G Src Grin2b 10862698,16635246 biogrid,intact exp, ortho G G G G Src Jak2 21102457 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Shc1 15716419 biogrid,i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G Src Trpc6 16407161 dip exp, ortho Src Src 10684249 biogrid,i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Tlr3 21911421 innatedb exp, ortho G G G G G G G G G G G G G G G G G G G G G G Src Gab1 12808090 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Arrb1 19122674 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Frs2 23452850 intact exp, ortho Prkaca Src 11804588 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Erbb3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Crebbp ortho G G G G G G G G G G G G G G G G G G G G G G G G G Cd46 Src ortho G G G G G G G Src Kit ortho G G G G G G G G G G G G G G G G G G G G G G Src Jmjd7 ortho Src Stat5a ortho G G G G G G G G G G G G G G G G G G Src Mapk15 ortho Src Nr3c1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Kat5 ortho Src Epor ortho G G G G G G G G G G G G G G G Src Rpp38 ortho Src Shb ortho Src Lig3 ortho G G G G G G G G G G G G G Src Tyro3 ortho G G G G G G G G G G G Src Cav2 ortho G G G G G G G G G G G G G G G G G G G G G G G G Src Polr2d ortho G G G G G G G G G G G G G G G G G G G G G G G G G Ythdc1 Src ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Rps6kb1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Skap2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Ikbkb Src ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Dlgap1 ortho Src Erbb2 ortho G G G G G G G G G G G G Src Parp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Polr2g ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Aldob ortho G G G G G G G G G G G G G G Src Polr2h ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Rasgrf1 ortho G G G G G G G G G G G G Src Ca3 ortho G G G G G G G G G G G G G G G G G G G G G G G G Src Pax3 ortho G G G Src Phf19 ortho G G G G G G G G G G Src Vil1 ortho G G G G G Src Ctf2 ortho Src Rxra ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Vdr ortho G G G G G G G G G G Tmem185a Src ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Jak1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Arhgap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Cdcp1 ortho G G G G G G G G G G G G G G G Src Chuk ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Plscr1 ortho G G G G G G G G G G G G G G G G G G G G Protein E230008N13Rik Src ortho Hdac3 Src ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Hras ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Atp1a1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Gab2 ortho G G G G Src Trat1 ortho G G Src Ppp2cb ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Ptpn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Tgm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G Src Drd4 ortho G G Src Srf ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Cltc ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Ddx58 ortho Cops5 Src ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src P2ry2 ortho G Src Psmb9 ortho G G G G G G G G G G G G G G G G G G G G G Src Rpl10 ortho Src Mylk ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Tpt1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Bcr ortho G G G G G G G G G G G G G G G G G G G G G G G G Src Fancc ortho G G G G G G G G G Src Anxa1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Vcl ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Gtf2i ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Ptpre ortho G G G G G G G G G G G G G G G G G G G G Src Ywhah ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Cav1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Pold1 ortho G G G G G G G G G G G G G G G G G G Fhit Src ortho G G G G G G G G G G G G G G G Src Nprl2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Ccna1 ortho Src Grin2a ortho Src Abce1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Sptan1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Cdk5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Protein Ankrd11 Src ortho Lnx1 Src ortho G G G G G G G G G G G G G G G G G G Src Tbk1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Akap6 ortho Protein Lct Src ortho G G G G Src Dlx4 ortho Src Rps6kb2 ortho G G G G G G G G G G G G G G G G G G G G G G G Inositol 1,4,5-trisphosphate 3-kinase B, MCG6217, Protein Itpkb Src ortho G G G G G G G G G G G G G G G G G G G G G G G G G Tp53 Src ortho G G G G G G G G G G G G G G G G G G G G G G G Src Fgr ortho G G G G G G G G G G Esr2 Src ortho G Src Dlg4 ortho G G G G G G G G G Src Kcna4 ortho G G G G G Src Fgfr1 ortho G G G G G G G G G G G G G G G G G G G G G G Src Afap1l2 ortho Src Grb2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Nos2 ortho G Protein Mki67 Src ortho G G G G G G G G G G G G G G G G G G Sp1 Src ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Rpl3 ortho Src Polr2k ortho Src Gab3 ortho G G G G Protein Rasa1 Src ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Rin3 ortho Src Bmx ortho G G G Akap2 Src ortho G G G G G G G G G G G G G G G G G G G G G G G Src Cd2ap ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Rras ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Asap2 ortho Src Sorbs1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Stat1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Mtnd2 Src ortho Src Celsr2 ortho G G G G G G G G G G G G G G G G G G Src Fyttd1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Actb ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Fbxo5 ortho Src Faslg ortho G Src Ptpn23 ortho G G G G G G G G G G G G G G G G G G G Src Braf ortho G G G G G G G G G G G G G G G G G G G G Src Tec ortho G G G G G G G G G G G G G G G G G G G Src Csk ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Cdc37 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Mapk3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Wwox ortho G G G G G G G G G G G G G G G G G Tnfsf11 Src ortho G G Src Mapk8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Prkci ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Pik3r1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Mapk10 ortho G G G G G G G G G G Src Arhgap32 ortho Src Med28 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Tnks ortho Src Gnb2l1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Ntrk1 ortho Src Cbll1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Adam17 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Asap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G Src Thrb ortho G G G G Src Kifap3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Hif1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Cblc ortho G G G G G G G G G G G G Src Thra ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Ddx4 ortho Src Ptprd ortho G G G G G G G G G G G G G G G G G G G G G G G Hcn2 Src ortho G G G G G G G G Src Fas ortho G G G G G G G G G G G G G G Src Trip10 ortho G G G G G G G G G G G G G G G G G G G G G G G G F2rl2 Src ortho G G G G G G G G G Src Mapt ortho G G G G G G G G G G G G G Src Dusp15 ortho G Src Nphs1 ortho G G G G Src Fcgr2 ortho G G G G G G G G G G G G G G G G G G G G Src Smarcd1 ortho G G G G G G G G G G G G G G G G G G G G G Src Polr2l ortho Cntnap1 Src ortho Src Pax7 ortho G Src Ctnnd1 ortho G G G G G G G G G G G G G G G G G G G G G G G Src Actn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Lrp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Tub ortho G G G G G G G Shroom2 Src ortho Src Mapk1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Cd97 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Protein Prdm2 Src ortho Src Ets1 ortho G G G G G G G G G G G G G G G G G G G G G G G G Src Dock3 ortho Src Calcium-transporting ATPase ortho Src Rtn4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Signal peptidase complex subunit 3, Signal peptidase complex subunit 3 homolog (S. cerevisiae) ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Pdss2 ortho Src Pecam1 ortho G G G G G G G G G G G G G G G G G G G G G G Src Daam1 ortho Src Tom1l1 ortho G G G G G G G G G G G G G G G G G G G G G Src Stx17 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Cttn ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Ptpn6 ortho G G G G G G G G G G G G G G G G G Src Dgkz ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Git1 ortho G G G G G G G G G G G G G G G G G G G G G Polr2j Src ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Zfp189 ortho G Src Nap1 ortho Src Cenpv ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Flnb ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Als2cr12 ortho Src Tulp4 ortho Smarce1 Src ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Csnk2a1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Adrb2 ortho G G G G G G G G Src Cdh1 ortho G G G G G G G G G G G G G G G G G G Src Fsd1 ortho Pdip Src ortho Sema3a Src ortho G G G G G G G G G G G Src Cdh5 ortho G G G G G G G G G G G G G G G G G Dgka Src ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Gucy2c ortho G G G G G Src Ppargc1b ortho G G G G G G G G G G G G G G G G G G G G G G Src Matk ortho G G G G G G G G Src Polr2f ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Sodium/hydrogen exchanger Src ortho Src Osteoregulin, Protein Mepe ortho G Src Flna ortho G G G G G G G G G G G G G G G G G G G G G G G G Src Dab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G Src Bag3 ortho G G G G G G G G G G G G G G G G G G G G G G G G Src Ralgapb ortho Slc6a18 Src ortho G G G G Src Grb10 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Agtr1a ortho Src Fanca ortho G G G G G G G G G G G G G G G G Src Ptger4 ortho G G G G G G G G G G G G G G G G G G G G G Src Runx3 ortho Src Tubb4b ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Kcnq5 ortho G G G Src Map2 ortho Src Sh2d2a ortho G G Src Gpi ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Kcna5 ortho G G G G G G G G G G Src Shank2 ortho Src Raf1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Hemgn ortho G G G Src Mllt4 ortho Src Sh3kbp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Dnm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Tecr ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Ctnnb1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Plcg1 ortho Araf Src ortho G G G G G G G G G G G G G G G G G G G G G G G G Nmt1 Src ortho G G G G G G G G G G G G G G G G G G G G G G G G G Snx3 Src ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Cd63 ortho Src Wbp11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Ccnl2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Pag1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Stap2 ortho G G G G G G G G G G G G G G G G G G G Src Epb41l3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Palld ortho G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Src ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Farp2 ortho G G G G G G G Src Mrpl24 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Cd44 ortho G G G G G G G G G G G G G G G G G G G G G G Src Dok4 ortho G G G G G G G G G G G G G Src Ostf1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Cul9 ortho G G G G G G G G G Src Isg20l2 ortho Src Egln1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Zp2 ortho G G G Abl1 Src ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Pelp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Ror1 ortho Src Pld2 ortho G G G G G G G G G G G G G G G G G G G Src Baat ortho Bmpr2 Src ortho G G G G G G G G G G G G G G G G Src Gjb1 ortho G G G G G G G G G Src Ar ortho G G G G G G G G G G G G G G Src Gsn ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Sh2d3c ortho G G G G G G G G G G G G G G G G Src Alk ortho G G G G G Src Galnt12 ortho Src Mical1 ortho G G G G G G G G G G G G G Src Fn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Dlgap4 Src ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Prkca ortho G G G G G G G G G G G G G G G G G G G Src Ptpn11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Eps8 ortho G G G G G G G G G G G G G G G G G G G G G G G G Src Polr2i ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Mertk ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Traf1 ortho G G G Src Prickle3 ortho Eif3d Src ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Ubox5 ortho G G G G G G G G G G G G G G G G Src Rps26 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Rora ortho G G G G G G G G G G G G G G G G G G G G G G G G Src Aire ortho Src Trip6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Atp5f1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Hes1 ortho G G G G G G G G G G G G G G G G G G G G G G G Pik3r2 Src ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Tiam1 ortho G G G G G G G G G G G G G G G G G G G G G Syn1 Src ortho G G G G G G G G G Src Ubc ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Nkx2-1 ortho G Src Pla2g4a ortho G G G G G G G G G G G G G G G G G G Src Map4k1 ortho G G G G G Protein Gltscr1 Src ortho Src Slc25a41 ortho Src Iqgap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Pkd1 Src ortho G G G G G G G G G G G G G G G G G G G G G G Src Polr2e ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Hnrnpk ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Skap1 ortho Mal Src ortho G G G G G G G G G G G G G G G G G G G Src Mapkapk3 ortho Src Pde6g ortho G G G Src Fbp2 ortho G G G G G G G G G G Src Nxph3 ortho G G G G G G G G G G G G G G G G G G G G G G G G Src Pld1 ortho G G G G G G G G G G G G G G G G G G G G G G Src Ddr2 ortho G G G G G G G G G G G G G G G G G Src Polr2c ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Ddx3y ortho G G G G G G G G G G G G G G G G G G G G G G Src Epha4 ortho G G G G G G G G Src Kcnb1 ortho G G G G G G G G G G Src Hoxb5 ortho G G G G G G Src Dapp1 ortho G G G G G G G G G G G G G G G Src Lcp2 ortho G G G G G G G G G G G Src Igf1r ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Cblb ortho Src Mapk8ip3 ortho G G G G G G G G G G G G G G G G G G G G G G G Src Ywhag ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Sirpa ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Tubb2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Ccna2 ortho G G G G G G G G G G G G G G G G G Src Xpa ortho G G G G G G G G G G G G G G G G G G G Src Dag1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Stat5b ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Stat6 ortho G G G G G G G G G G G G G G G G G G G G G G G Src Gns ortho G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Src ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Rara ortho G G Src Afap1 ortho Src Asb16 ortho G G Src Id4 ortho G G G G G G G G G G G G G G G G G G G G G G Src Crmp1 ortho G G G G G G G G G Src Mst1r ortho G G G G G G G Src Prkcz ortho G G G G G G G G G G G G G G G G G G G Src Protein Rapgef1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Snx17 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Ctsl ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Abl2 ortho G G G G G G G G G Src Traf3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Fbxo18 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Crk ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Dok1 ortho G G G G G G G G G G G G G G G G G Src Tnfrsf1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Hnf1a ortho Src Sin3a ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Rgs16 ortho G G G G G G G Src Pdpk1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Jup ortho G G G G G G G G G G G G G G G G G G G G G G G Sh3pxd2a Src ortho G Src Prkd1 ortho G G G G G G G G G G G G G G G Gfap Src ortho G G G G G Src Cacna1c ortho G G G G G G G G G G G G Src Dock1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Mavs ortho G G G G G G G G G G G G G G G G G G G G G G G Src Kcnd3 ortho Src Cast ortho G G G G G G G G G G G G G G G G G G G G G G G G Src Ccnd1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Prkacb ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Nfkbia ortho G G G G G G G G G G G G G G G G G G G G G G G G G Ccdc8 Src ortho Src Polr2b ortho G G G G G G G G G G G G G G G G G G G G G G G G G Efna5 Src ortho Src Adrbk1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Polr2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Smarcb1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Ptpn2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Foxo1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Trpv4 ortho G G Src Dlgap3 ortho Src Protein Taf15, TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor ortho Src Arhgap17 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Anxa2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Ndfip2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Ptpn18 ortho G G G G G G G G G G G G G G G G G G G Src Pgr ortho G Src Acap1 ortho Src Cfl1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Itk ortho G G G Src Lck ortho G G G G G G G G G G G G G Src Cd59b ortho Src Ppp2r4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Pou2f1 ortho G G G G G G G G G G G G G G G G G G G G G G G Ikbkg Src ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Axl ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Anxa7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Abi1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Lyn ortho Src Usp8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Ckap5 Src ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Ogn ortho G G G G G G G G G G G G G G G G G G G G G G G G Src Hck ortho G G G G G G G G G G G G G G G G G Src Map2k1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Ednra ortho G G G G G G Tert Src ortho Nr1i2 Src ortho G G G G Src Ets2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Prkcd ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Phosphatase and actin regulator ortho G G G G G G G G G G G G G G G G G G G Src Inppl1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Hsp90aa1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Mrps30 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Fyn ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Shank3 ortho G G G G G G G G G G G G G G G G G G G G Src Mpzl1 ortho Src Pdk1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Hoxc8 ortho G G G G G G G G Src N-acetylneuraminic acid synthase (Sialic acid synthase), Protein Nans ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Cdkn1b ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Cyp4f3 ortho G G G G G G G G Src Prkch ortho G G G G G G G G G G G G G G G G Src Pik3r3 ortho Fyb Src ortho G G G G G G G G G G G G G G G Src Dlgap2 ortho Src Fgfr2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Ppard ortho Src Kcnma1 ortho G G G G G G G G G G G G G G G G G G Src Tns3 ortho Src Extl3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Arr3 ortho G Src Acta1 ortho G G G G G G G G G G G G G G G G G G G G G G G Src Ptprr ortho G G G G G G G G G G G G G G G G Src Txk ortho G G Src Cd36 ortho G G G G G G G G G G G G G G G G G G G G G Snca Src ortho G G G G G G G G G G G G G G G Src Dock8 ortho G G G G G G G G G G G G G G G G G G G Src Pak2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Sos2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Il6ra ortho G G G G G G G G G G G Tnfrsf11a Src ortho G G G G G G G Srpk2 Src ortho G G G G G G G G G G G G G G G G G G G G G G G G G Src Arhgap35 ortho G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P05132 P05480 enzymatic study 11804588 direct interaction X 2 Q91YI4 P05480 affinity chromatography technology 19122674 physical association X 2 Q91YI4 P05480 affinity chromatography technology 19122674 physical association X 2 P05480 K7QD41 affinity chromatography technology 14739300 physical association X 2 P05480 P05480 enzymatic study 10684249 direct interaction X 2 P05480 P10598 enzymatic study 10684249 direct interaction X 2 P05480 enzymatic study 10684249 direct interaction X 2 P05480 Q64355 pull down 8647432 direct interaction X 2 P05480 O08808 affinity chromatography technology 18194650 physical association X 2 P05480 K7QD41 affinity chromatography technology 11274221 physical association X 2 P05480 P97318-3 affinity chromatography technology 15062102 physical association X 2 P05480 P09581 affinity chromatography technology 17420256 physical association X 2 P05480 P31750 affinity chromatography technology 19122674 physical association X 2 P05480 P31750 affinity chromatography technology 19122674 physical association X 2 P05480 Q60838 affinity chromatography technology 19920076 physical association X 2 P05480 Q60838 affinity chromatography technology 19920076 physical association X 2 P05480 Q60838 enzymatic study 19920076 direct interaction X 2 P05480 G5E852 affinity chromatography technology 21102457 physical association X 2 P51637 P05480 biochemical 8663016 colocalization X 2 P51637 P05480 affinity chromatography technology 14600260 physical association X 2 Q9QYY0 P05480 affinity chromatography technology 12808090 physical association X 2 P05480 affinity chromatography technology 18602463 physical association X 2 Q01279 P05480 affinity chromatography technology 11274221 physical association X 2 P16054 P05480 affinity chromatography technology 11834516 physical association X 2 P16054 P05480 pull down 11834516 direct interaction X 2 P15208 P05480 affinity chromatography technology 19122674 physical association X 2 O08530 P05480 affinity chromatography technology 21102457 physical association X 2 P05480 A2AI14 affinity chromatography technology 10862698 physical association X 2 P05480 B5B2N4 affinity chromatography technology 20037154 physical association X 2 P05480 Q9CQV6 affinity chromatography technology 22138575 physical association X 2 P05480 Q9ES52-4 affinity chromatography technology 16601135 physical association X 2 P05480 affinity chromatography technology 18194650 physical association X 2 P05480 affinity chromatography technology 18194650 physical association X 2 P05480 Q5U3L0 enzymatic study 22153076 direct interaction X 2 P05480 Q8VI36 affinity chromatography technology 14636584 physical association X 2 P05480 Q8VI36 enzymatic study 14636584 direct interaction X 2 P05480 P19785 affinity chromatography technology 17921256 physical association X 2 P05480 A0A0A6YW06 pull down 8861907 direct interaction X 2 P05480 affinity chromatography technology 15716419 physical association X 2 P05480 affinity chromatography technology 19122674 physical association X 2 P05480 Q9Z0Z3-2 affinity chromatography technology 20596523 physical association X 2 Q8R4N0 P05480 affinity chromatography technology 11804588 physical association X 2 P22682 P05480 affinity chromatography technology 8849724 physical association X 2 P22682 P05480 enzymatic study 8849724 direct interaction X 2 P22682 P05480 affinity chromatography technology 9013636 physical association X 2 P22682 P05480 affinity chromatography technology 9013636 physical association X 2 P22682 P05480 enzymatic study 9013636 direct interaction X 2 P22682 P05480 affinity chromatography technology 22138575 physical association X 2 P22682 P05480 affinity chromatography technology 17420256 physical association X 2 P22682 P05480 affinity chromatography technology 8635998 physical association X 2 P17182 P05480 enzymatic study 9013636 direct interaction X 2 P17182 P05480 enzymatic study 14739300 direct interaction X 2 Q99N57 P05480 enzymatic study 10205168 direct interaction X 2 Q61120 P05480 affinity chromatography technology 15716419 physical association X 2 P0CG48 P05480 affinity chromatography technology 20596523 physical association X 2 Q8BMC3 P05480 affinity chromatography technology 15716419 physical association X 2 Q60749 P05480 enzymatic study 10844001 direct interaction X 2 Q60749 P05480 enzymatic study 15890643 direct interaction X 2 Q01097 P05480 affinity chromatography technology 10862698 physical association X 2 P05480 far western blotting 9539797 association C 4 P05480 anti bait coimmunoprecipitation 21282606 - C 3 P05480 anti bait coimmunoprecipitation 19122674 - C 3 P05480 anti bait coimmunoprecipitation 21282606 - C 4 P05480 P09581 anti bait coimmunoprecipitation 18840695 physical association X 2 P05480 P31750 anti bait coimmunoprecipitation 19122674 physical association X 2 P05480 P31750 anti bait coimmunoprecipitation 19122674 physical association X 2 P05480 P31750 anti bait coimmunoprecipitation 19122674 physical association X 2 P05480 pull down 16407161 direct interaction X 2 Q13507-3 P05480 anti tag coimmunoprecipitation 16407161 direct interaction X 2 Q13507-3 P05480 anti bait coimmunoprecipitation 16407161 direct interaction X 2 Q13507-3 P05480 pull down 16407161 direct interaction X 2 Q13507-3 P05480 pull down 16407161 direct interaction X 2 P05480 anti bait coimmunoprecipitation 18840695 physical association X 2 P05480 anti bait coimmunoprecipitation 19122674 - C 3 P05480 anti bait coimmunoprecipitation 19122674 - C 4 P15208 P05480 anti bait coimmunoprecipitation 19122674 physical association X 2 P15208 P05480 anti bait coimmunoprecipitation 19122674 physical association X 2 P05480 P23242 anti bait coimmunoprecipitation 21282606 physical association X 2 P05480 P23242 anti bait coimmunoprecipitation 21282606 physical association X 2 P05480 P23242 anti bait coimmunoprecipitation 21282606 physical association X 2 P05480 Q9R244 pull down 16407161 direct interaction X 2 P05480 Q0VB97 pull down 16407161 direct interaction X 2 P05480 Q9QX29 pull down 16407161 direct interaction X 2 P05480 Q61143 pull down 16407161 direct interaction X 2 P05480 cosedimentation through density gradient 16635246 colocalization C 608 Q05397 P05480 nuclear magnetic resonance 18560762 direct interaction X 2 Q05397 P05480 nuclear magnetic resonance 21266176 direct interaction X 2 Q05397 P05480 nuclear magnetic resonance 21266176 direct interaction X 2 Q05397 P05480 nuclear magnetic resonance 21266176 direct interaction X 2 Q05397 P05480 isothermal titration calorimetry 21266176 direct interaction X 2 P05480 affinity chromatography technology 16635246 association C 94 P05480 coimmunoprecipitation 11139474 association C 37 P05480 affinity chromatography technology 10862698 association C 58 P05480 anti bait coimmunoprecipitation 16635246 association C 96 P05480 affinity chromatography technology 16635246 association C 83 P05480 anti bait coimmunoprecipitation 19146815 association C 3 P49023 P05480 fluorescent resonance energy transfer 16478788 physical association X 2 P49023 P05480 fluorescent resonance energy transfer 16478788 physical association X 2 P54763 P05480 fluorescence microscopy 16298995 colocalization X 2 P54763 P05480 anti bait coimmunoprecipitation 16298995 physical association X 2 P54763 P05480 anti bait coimmunoprecipitation 16298995 physical association X 2 P05480 Q00960 anti bait coimmunoprecipitation 16990796 physical association X 2 P05480 Q8C180 fluorescence polarization spectroscopy 23452850 direct interaction X 2 P05480 P07333 coimmunoprecipitation 7730365 association X 2 P05480 P08050 pull down 9278444 association X 2 Q63767 P05480 fluorescent resonance energy transfer 16478788 physical association X 2 Q63767 P05480 anti bait coimmunoprecipitation 16478788 physical association X 2 P05480 coimmunoprecipitation 10862698 association C 59 P18052 P05480 protein kinase assay 7518772 phosphorylation reaction X 2 P18052 P05480 protein kinase assay 7518772 phosphorylation reaction X 2 P07141 P05480 pull down 16267818 physical association X 2 P07141 P05480 anti bait coimmunoprecipitation 16267818 physical association X 2 P34152 P05480 anti bait coimmunoprecipitation 18233957 physical association X 2 P05480 Q8T4F7 pull down 10220404 physical association X 2 P05480 Q8T4F7 pull down 10220404 physical association X 2 P05480 Q9WU78 pull down 15557335 physical association X 2 P05480 Q9WU78 pull down 15557335 physical association X 2 P05480 O70469 anti bait coimmunoprecipitation 15831486 physical association X 2 P05480 O70469 anti bait coimmunoprecipitation 15831486 physical association X 2 P05480 O70469 anti tag coimmunoprecipitation 15831486 physical association X 2 P05480 O70469 pull down 15831486 physical association X 2 P05480 Q8VI36 anti tag coimmunoprecipitation 16478788 physical association X 2 P05480 O13016 anti bait coimmunoprecipitation 16522684 physical association X 2 P05480 P97288 anti bait coimmunoprecipitation 19661922 physical association X 2 P05480 Q00959 protein kinase assay 21199370 phosphorylation reaction X 2 P05480 Q00959 protein kinase assay 21199370 phosphorylation reaction X 2 P05480 P05480 protein kinase assay 21199370 phosphorylation reaction Y 1 P05480 Q00959 surface plasmon resonance 21199370 direct interaction X 2 P05480 P05480 protein kinase assay 21199370 phosphorylation reaction Y 1 P05480 P05480 protein kinase assay 21199370 phosphorylation reaction Y 1 P05480 P05480 protein kinase assay 21199370 phosphorylation reaction Y 1 P05480 P05480 protein kinase assay 21199370 phosphorylation reaction Y 1 P05480 Q00959 protein kinase assay 21199370 phosphorylation reaction X 2 P05480 Q00959 protein kinase assay 21199370 phosphorylation reaction X 2 P05480 Q9CQV6 fluorescence microscopy 22732841 colocalization X 2 P35546 P05480 fluorescence microscopy 22732841 colocalization X 2 P35546 P05480 anti bait coimmunoprecipitation 22732841 physical association X 2 Q01973 P05480 anti bait coimmunoprecipitation 22439932 physical association X 2 Q01973 P05480 protein kinase assay 22439932 phosphorylation reaction X 2 Q01973 P05480 anti tag coimmunoprecipitation 22439932 physical association X 2 P05106 P05480 enzyme linked immunosorbent assay 14593208 direct interaction X 2 P05106 P05480 pull down 14593208 physical association X 2 P05106 P05480 pull down 14593208 physical association X 2 P05106 P05480 anti bait coimmunoprecipitation 14593208 physical association X 2 P05106 P05480 anti bait coimmunoprecipitation 14593208 physical association X 2 P70315 P05480 anti tag coimmunoprecipitation 18289379 physical association X 2 P70315 P05480 anti bait coimmunoprecipitation 18289379 physical association X 2 P31016 P05480 pull down 16990796 physical association X 2 P31016 P05480 pull down 16990796 direct interaction X 2 P31016 P05480 anti bait coimmunoprecipitation 16990796 physical association X 2 P31016 P05480 enzyme linked immunosorbent assay 16990796 direct interaction X 2 P31016 P05480 pull down 16990796 physical association X 2 P31016 P05480 enzyme linked immunosorbent assay 16990796 direct interaction X 2 P31016 P05480 pull down 16990796 direct interaction X 2 P31016 P05480 pull down 16990796 direct interaction X 2 P31016 P05480 pull down 16990796 physical association X 2 P16054 P05480 coimmunoprecipitation 11834516 - X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B S1pr1 Src MI:0029(cosedimentation through density gradient)|MI:0004(affinity chromatography technology) 16635246,21102457 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0915(physical association) (intact)|(biogrid) UniProt_166352|BIOGRID_320144 neutral component|prey neutral component|bait Src Csn2 MI:0415(enzymatic study) 10684249 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_322071 bait prey Src Dab1 MI:0004(affinity chromatography technology) 15062102 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_325790 prey bait Diaph1 Src MI:0027(cosedimentation)|MI:0004(affinity chromatography technology) 16615898,18194650 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0915(physical association) (intact)|(biogrid) UniProt_167131|BIOGRID_323148 neutral component|prey neutral component|bait Prkaca Src MI:0004(affinity chromatography technology)|MI:0027(cosedimentation) 11804588,16615898 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0403(colocalization) (biogrid)|(intact) BIOGRID_322734|UniProt_167116 bait|neutral component prey|neutral component Src Egfr MI:0004(affinity chromatography technology) 11274221 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_324424 bait prey Src Shc1 MI:0004(affinity chromatography technology) 15716419 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_329522 prey bait Src Ephb2 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 16298995 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization) (intact)|(intact)|(intact) UniProt_166095|UniProt_166096|UniProt_166101 bait|prey|neutral component prey|bait|neutral component Src Eno1 MI:0027(cosedimentation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0029(cosedimentation through density gradient)|MI:0027(cosedimentation)|MI:0027(cosedimentation) 14739300,16615898,16635246,9013636 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization) (intact)|(biogrid)|(biogrid)|(intact)|(intact)|(intact) UniProt_167131|BIOGRID_321384|BIOGRID_321392|UniProt_166352|UniProt_167115|UniProt_167116 neutral component|bait|bait|neutral component|neutral component|neutral component neutral component|prey|prey|neutral component|neutral component|neutral component Src Shc3 MI:0004(affinity chromatography technology) 15716419 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_329525 prey bait Src Pik3c2a MI:0415(enzymatic study) 10684249 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_322072 bait prey Src Csf1 MI:0096(pull down)|MI:0096(pull down) 16267818 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_164525|UniProt_164526 prey|prey bait|bait Src Grin2b MI:0029(cosedimentation through density gradient)|MI:0029(cosedimentation through density gradient)|MI:0004(affinity chromatography technology) 10862698,16635246 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0914(association)|MI:0915(physical association) (intact)|(intact)|(biogrid) UniProt_166352|UniProt_166358|BIOGRID_321149 neutral component|prey|prey neutral component|prey|bait Src Skp2 MI:0004(affinity chromatography technology) 20596523 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_316446 prey bait Dok2 Src MI:0096(pull down)|MI:0096(pull down)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0096(pull down)|MI:0096(pull down)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 15831486 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|MI:0471(mint)|MI:0471(mint) UniProt_165125|UniProt_165127|MINT_60091|MINT_60090|UniProt_165131|UniProt_165130|MINT_60086|MINT_60089 prey|bait|prey|prey|bait|prey|bait|bait bait|prey|bait|bait|prey|bait|prey|prey Atxn2 Src MI:0018(two hybrid) 18602463 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_333036 bait prey Src Prkce MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0029(cosedimentation through density gradient)|MI:0019(coimmunoprecipitation) 11139474,11834516,16635246 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0407(direct interaction)|MI:0403(colocalization)|MI:0914(association) (biogrid)|(biogrid)|(intact)|(intact) BIOGRID_311877|BIOGRID_311878|UniProt_166352|UniProt_160721 prey|bait|neutral component|prey bait|prey|neutral component|bait Src Csf1r MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation) 17420256,18840695 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0465(dip) BIOGRID_327989|DIP_634 bait|- prey|- Src Nfatc1 MI:0004(affinity chromatography technology) 20037154 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_321407 prey bait Src Inpp5d MI:0004(affinity chromatography technology) 16601135 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_322033 bait prey Src Raf1 MI:0415(enzymatic study) 10205168 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_328821 bait prey Src Ptpra MI:0027(cosedimentation)|MI:0096(pull down)|MI:0096(pull down) 16615898,7518772 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0217(phosphorylation reaction)|MI:0217(phosphorylation reaction) (intact)|(intact)|(intact) UniProt_167131|UniProt_177625|UniProt_177624 neutral component|unspecified role|unspecified role neutral component|unspecified role|unspecified role Src Cbl MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17420256,22138575,8635998,8849724,9013636 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_321292|BIOGRID_321291|BIOGRID_328557|BIOGRID_321382|BIOGRID_321555|BIOGRID_321383|BIOGRID_327990|BIOGRID_321379 bait|bait|bait|prey|prey|bait|bait|bait prey|prey|prey|bait|bait|prey|prey|prey Src Map1lc3b MI:0004(affinity chromatography technology)|MI:0416(fluorescence microscopy) 22138575,22732841 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0403(colocalization) (biogrid)|(intact) BIOGRID_321554|UniProt_175770 prey|neutral component bait|neutral component Src Sh3bp2 MI:0004(affinity chromatography technology) 22153076 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_326143 bait prey Src Pxn MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0055(fluorescent resonance energy transfer) 14636584,16478788,16615898 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0403(colocalization)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(intact)|(biogrid)|(biogrid)|(intact) UniProt_167131|UniProt_167135|BIOGRID_328573|BIOGRID_328574|UniProt_166053 neutral component|neutral component|prey|bait|bait neutral component|neutral component|bait|prey|prey Src Ret MI:0416(fluorescence microscopy)|MI:0416(fluorescence microscopy) 22732841 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0915(physical association) (intact)|(intact) UniProt_175769|UniProt_175773 neutral component|bait neutral component|prey Src Enah MI:0027(cosedimentation)|MI:0096(pull down) 16615898,8861907 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_167115|BIOGRID_328986 neutral component|prey neutral component|bait Src Khdrbs1 MI:0415(enzymatic study)|MI:0415(enzymatic study) 10844001,15890643 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_320263|BIOGRID_322109 bait|bait prey|prey Src Grin1 MI:0029(cosedimentation through density gradient)|MI:0029(cosedimentation through density gradient)|MI:0029(cosedimentation through density gradient)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 10862698,16635246 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0403(colocalization)|MI:0914(association)|MI:0915(physical association)|MI:0914(association) (intact)|(intact)|(intact)|(biogrid)|(intact) UniProt_166356|UniProt_166352|UniProt_166353|BIOGRID_321145|UniProt_161728 prey|neutral component|prey|prey|prey bait|neutral component|bait|bait|bait Src Dvl2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19920076 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_314873|BIOGRID_314869|BIOGRID_314875 prey|bait|prey bait|prey|bait Src Clybl MI:0004(affinity chromatography technology) 11804588 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_322733 bait prey Src Cav3 MI:0004(affinity chromatography technology)|MI:0401(biochemical) 14600260,8663016 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0403(colocalization) (biogrid)|(biogrid) BIOGRID_325940|BIOGRID_325421 bait|prey prey|bait Src Kdr MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18194650 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_323151|BIOGRID_323152 bait|prey prey|bait Src Frs2 MI:0053(fluorescence polarization spectroscopy) 23452850 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (intact) UniProt_175972 neutral component neutral component Itgb3 Src MI:0027(cosedimentation)|MI:0006(anti bait coimmunoprecipitation) 16615898,18840695 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0915(physical association) (intact)|MI:0465(dip) UniProt_167135|DIP_635 neutral component|- neutral component|- Src Ptk2b MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 11274221,14739300 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_321391|BIOGRID_324425 prey|bait bait|prey Src Shc2 MI:0004(affinity chromatography technology) 15716419 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_329523 prey bait Src Dnm1 MI:0006(anti bait coimmunoprecipitation)|MI:0029(cosedimentation through density gradient)|MI:0027(cosedimentation)|MI:0027(cosedimentation) 10,16615898,16635246 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization) MI:0471(mint)|(intact)|(intact)|(intact) MINT_71638|UniProt_166352|UniProt_167115|UniProt_167116 bait|neutral component|neutral component|neutral component null|neutral component|neutral component|neutral component Src Esr1 MI:0004(affinity chromatography technology) 17921256 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_328825 prey bait Src Was MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 18289379 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_168033|UniProt_168035 prey|prey bait|bait Src Ptk2 MI:0027(cosedimentation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 10,16615898,18233957 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|MI:0471(mint) UniProt_167131|UniProt_169313|MINT_74700 neutral component|prey|prey neutral component|bait|bait Src Efs MI:0686(unspecified method) 8647432 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_322644 bait prey Src Jak2 MI:0004(affinity chromatography technology) 21102457 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_320145 bait prey Src Pdcd6ip MI:0027(cosedimentation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0096(pull down)|MI:0006(anti bait coimmunoprecipitation)|MI:0096(pull down)|MI:0027(cosedimentation) 15557335,16615898 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization) (intact)|(intact)|(intact)|(intact)|MI:0471(mint)|(intact)|MI:0471(mint)|(intact) UniProt_167131|UniProt_81194|UniProt_165599|UniProt_165598|MINT_69746|UniProt_81195|MINT_69744|UniProt_167135 neutral component|bait|bait|bait|bait|bait|bait|neutral component neutral component|prey|prey|prey|prey|prey|prey|neutral component

PPI - HINT Gene A Gene B PMID Method Quality PRKACA SRC 11804588 0415 LC SRC SRC 10684249,9010229,8816475,10524630,21199370 0415,0045,0045,0045,0424 LC SRC PDGFRB 9010229 0045 LC SRC CSN2 10684249 0415 LC SRC PRKCE 11834516,11139474,11834516,11834516 0004,0019,0096,0019 LC SRC ENO1 9013636,14739300 0415,0415 LC SRC PTPRA 7518772 0424 LC SRC CBL 9013636,9013636,8849724,8849724 0004,0415,0004,0415 LC SRC PTK2 10931187,9032297,11278488,11278488,7997267,7997267,9566877,9566877,9774338,9032297,7997267,15572128,8816475,9032297,8816475 0019,0045,0004,0019,0019,0045,0004,0019,0045,0004,0004,0019,0019,0019,0045 LC SRC GRIN1 10862698,10862698 0004,0019 LC SRC RET 22732841,22732841 0416,0006 LC SRC STAT3 11278353 0045 LC SRC CAV3 8663016 0401 LC SRC EFNB1 8878483 0045 LC SRC EFNB2 8878483 0045 LC SRC EPHB2 16298995,16298995 0416,0006 LC SRC YWHAE 16615898 0027 LC SRC DCC 15494734,15494734 0045,0019 LC SRC SH3BP2 22153076 0415 LC SRC GRID2IP 11826110 0018 LC SRC KHDRBS1 10844001,15890643,7537265,7537265 0415,0415,0045,0004 LC SRC DVL2 19920076,19920076 0415,0004 LC SRC BCAR1 9032297,10739664,9032297,9032297 0045,0018,0019,0004 LC SRC PIK3C2A 10684249 0415 LC SRC SH3GL1 16054026 0045 LC SRC FRS2 23452850 0053 LC SRC NGEF 15848799 0045 LC SRC PXN 14636584,14636584,14636584,14636584 0019,0045,0004,0415 LC SRC MAP1LC3B 22732841 0416 LC SRC YWHAB 16635246 0029 LC SRC PTK2B 9774338 0019 LC SRC PDCD6IP 15557335,15557335,15557335,15557335 0019,0004,0096,0045 LC S1PR1 SRC 21102457 0004 LC DIAPH1 SRC 18194650 0004 LC ITGB3 SRC 18840695 0006 LC ATXN2 SRC 18602463 0004 LC DOK2 SRC 15831486,15831486,15831486 0006,0096,0007 LC ADAM15 SRC 13679040 0004 LC NFATC1 SRC 20037154 0004 LC SRC CSF1 16267818,16267818 0006,0096 LC SRC CSF1R 17420256,18840695 0004,0006 LC SRC INSR 19122674,19122674 0004,0006 LC SRC PRKCE 11834516,11834516,11834516 0004,0096,0019 LC SRC ESR1 17921256 0004 LC SRC CBL 9013636,17420256,22138575,8635998,9013636,8849724,11804588,8849724 0004,0004,0004,0004,0415,0004,0004,0415 LC SRC GJA1 21282606 0006 LC SRC AKT1 19122674,19122674 0004,0006 LC SRC PTK2 9032297,11278488,11278488,7997267,16966330,7997267,9566877,9566877,18233957,9032297,7997267,9032297 0045,0004,0019,0019,0004,0045,0004,0019,0006,0004,0004,0019 LC SRC GRIN1 16635246,10862698,16635246,10862698 0004,0004,0006,0019 HT SRC RET 22732841,22732841 0416,0006 LC SRC KDR 16966330,18194650 0004,0004 LC SRC CAV3 14600260,8663016 0004,0401 LC SRC EPHB2 16298995,16298995 0416,0006 LC SRC SH3BP1 8402898 0004 LC SRC WAS 18289379,18289379 0006,0007 LC SRC EVL 10945997 0004 LC SRC HTR4 19661922 0006 LC SRC DAB1 15062102 0004 LC SRC SHC1 15716419 0004 LC SRC GRIN2B 16635246,10862698 0004,0004 HT SRC EGFR 11274221 0004 LC SRC ENAH 8861907 0096 LC SRC KHDRBS1 7537265,7537265 0045,0004 LC SRC DVL2 19920076,19920076 0415,0004 LC SRC TRPC1 16407161 0096 LC SRC SHC3 15716419 0004 LC SRC BCAR1 11278488,9032297,9032297,9032297 0004,0045,0019,0004 LC SRC TRPC6 16407161 0096 LC SRC JAK2 21102457 0004 LC SRC SOS1 8402898 0004 LC SRC EFS 8647432 0096 LC SRC SHC2 15716419 0004 LC SRC ARRB1 19122674 0004 LC SRC PXN 14636584,14636584,16478788,14636584,14636584 0019,0045,0007,0004,0415 LC SRC ARRB2 19122674 0004 LC SRC MAP1LC3B 22138575 0004 LC SRC INPP5D 16601135 0004 LC SRC TRPC4 16407161 0096 LC SRC PTK2B 11274221,14739300 0004,0004 LC SRC SRCIN1 19146815 0006 LC SRC TRPC5 16407161 0096 LC SRC GAB1 12808090 0004 LC SRC TRPC2 16407161 0096 LC SRC PDCD6IP 15557335,15557335,15557335,15557335 0019,0004,0096,0045 LC SRC SKP2 20596523 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q60838 P05480 DVL2 SRC 0.569 19920076 Q61120 P05480 SHC3 SRC 0.21 15716419 Q61140 P05480 BCAR1 SRC 0.21 11038351 Q05397 P05480 PTK2 SRC 0.671 21266176,18560762 P62259 P05480 YWHAE SRC 0.081 16615898 Q8T4F7 P05480 ENA SRC 0.376 10220404 P05480 O70305 SRC ATXN2 0.21 18602463 Q9WU78 P05480 PDCD6IP SRC 0.21 15557335 Q9Z0Z3 P05480 SKP2 SRC 0.21 20596523 P08050 P05480 GJA1 SRC 0.21 9278444 Q62469 P05480 ITGA2 SRC 0.21 11038351 Q8BMC3 P05480 SHC2 SRC 0.21 15716419 Q8BWG8 P05480 ARRB1 SRC 0.21 19122674 P09581 P05480 CSF1R SRC 0.376 18840695,17420256 P05480 P05132 SRC PRKACA 0.309 11804588 P05480 O08530 SRC S1PR1 0.21 21102457 P05480 O08808 SRC DIAPH1 0.21 18194650 P05480 O54890 SRC ITGB3 0.21 18840695 P05480 O70469 SRC DOK2 0.507 15831486 P05480 P05480 SRC SRC 0.332 10684249 P10598 P05480 CSN2 SRC 0.309 10684249 P16054 P05480 PRKCE SRC 0.569 11834516,11139474 Q00960 P05480 GRIN2B SRC 0.21 16990796 Q01279 P05480 EGFR SRC 0.21 11274221 Q61194 P05480 PIK3C2A SRC 0.309 10684249 Q62120 P05480 JAK2 SRC 0.21 21102457 Q64355 P05480 EFS SRC 0.309 8647432 Q8C180 P05480 FRS2 SRC 0.309 23452850 Q9ES52 P05480 INPP5D SRC 0.21 16601135 P07333 P05480 CSF1R SRC 0.21 7730365 P17182 P05480 ENO1 SRC 0.523 14739300,9013636 P54763 P05480 EPHB2 SRC 0.309 16298995 Q60749 P05480 KHDRBS1 SRC 0.523 15890643,10844001 P07141 P05480 CSF1 SRC 0.376 16267818 Q9CQV6 P05480 MAP1LC3B SRC 0.309 22732841,22138575 Q01097 P05480 GRIN2B SRC 0.236 16635246,10862698 P22682 P05480 CBL SRC 0.908 8635998,17420256,22138575,11804588,8849724,9013636 P34152 P05480 PTK2 SRC 0.376 18233957,16966330 P31016 P05480 DLG4 SRC 0.888 16990796 P35438 P05480 GRIN1 SRC 0.49 10862698,16635246 Q8VI36 P05480 PXN SRC 0.454 14636584 Q91YI4 P05480 ARRB2 SRC 0.376 19122674 P31750 P05480 AKT1 SRC 0.376 19122674 P35546 P05480 RET SRC 0.309 22732841 Q9CQV8 P05480 YWHAB SRC 0.081 16635246 Q9QVP9 P05480 PTK2B SRC 0.376 11274221,14739300 Q9QWI6 P05480 SRCIN1 SRC 0.21 19146815 Q9QYY0 P05480 GAB1 SRC 0.21 12808090 P18052 P05480 PTPRA SRC 0.033 7518772 P97288 P05480 HTR4 SRC 0.21 19661922 P97318 P05480 DAB1 SRC 0.21 15062102 P98083 P05480 SHC1 SRC 0.21 15716419 Q00959 P05480 GRIN2A SRC 0.354 21199370 P51637 P05480 CAV3 SRC 0.309 14600260,8663016 P19785 P05480 ESR1 SRC 0.21 17921256 Q01973 P05480 ROR1 SRC 0.396 22439932 Q03173 P05480 ENAH SRC 0.309 8861907 P15208 P05480 INSR SRC 0.21 19122674 P05480 O13016 SRC PTPN1 0.21 16522684