PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q70SY1-3 D3YUA5 pull down 23955342 direct interaction X 2 Q70SY1-3 D3YUA5 affinity chromatography technology 23955342 physical association X 2 Q70SY1-3 D3YUA5 enzymatic study 23955342 direct interaction X 2 P0CG63 D3YUA5 pull down 21070969 direct interaction X 2 Q9QUR7 D3YUA5 affinity chromatography technology 22608923 physical association X 2 Q9QUR7 D3YUA5 affinity chromatography technology 22608923 physical association X 2 P97287 D3YUA5 affinity chromatography technology 21368834 physical association X 2 D3YUA5 affinity chromatography technology 18625840 physical association X 2 D3YUA5 pull down 18625840 direct interaction X 2 D3YUA5 P10242-7 affinity chromatography technology 19421138 physical association X 2 Q3V341 D3YUA5 affinity chromatography technology 20815813 physical association X 2 P28867 D3YUA5 affinity chromatography technology 20815813 physical association X 2 P20444 D3YUA5 affinity chromatography technology 20815813 physical association X 2 P16054 D3YUA5 two hybrid 20815813 direct interaction X 2 P16054 D3YUA5 affinity chromatography technology 20815813 physical association X 2 P16054 D3YUA5 affinity chromatography technology 20815813 physical association X 2 D3YUA5 affinity chromatography technology 20815813 physical association X 2 Q9WTX6 D3YUA5 affinity chromatography technology 11735228 physical association X 2 Q9WTX5 D3YUA5 affinity chromatography technology 11735228 physical association X 2 Q9WTX5 D3YUA5 affinity chromatography technology 23955342 physical association X 2 P49715 D3YUA5 affinity chromatography technology 20534483 physical association X 2 P49715 D3YUA5 affinity chromatography technology 20534483 physical association X 2 Q96BA8 D3YUA5 pull down 23955342 direct interaction X 2 Q96BA8 D3YUA5 affinity chromatography technology 23955342 physical association X 2 Q96BA8 D3YUA5 enzymatic study 23955342 direct interaction X 2

PPI - HINT Gene A Gene B PMID Method Quality JUN FBXW7 14739463,14739463,14739463,14739463 0004,0019,0045,0018 LC PRKCE FBXW7 20815813,20815813 0018,0004 LC GATA2 FBXW7 25670854 0004 LC PPARGC1A FBXW7 25918410 0004 LC MYC FBXW7 25670854 0004 LC JUN FBXW7 14739463,14739463,14739463,14739463 0004,0019,0045,0018 LC MYB FBXW7 25670854 0004 LC PRKCE FBXW7 20815813,20815813 0018,0004 LC PRKCA FBXW7 20815813 0004 LC PRKCD FBXW7 20815813 0004 LC PRKCB FBXW7 20815813 0004 LC MCL1 FBXW7 21368834 0004 LC PRKCZ FBXW7 20815813 0004 LC RUNX2 FBXW7 26542806 0004 LC NPM1 FBXW7 18625840,18625840 0004,0096 LC FBXW7 MTOR 21076392 0006 LC FBXW7 PIN1 22608923 0004 LC FBXW7 SKP1 11735228,23955342,25670854 0004,0004,0004 LC FBXW7 CUL1 11735228,25670854 0004,0004 LC FBXW7 GSK3B 26542806 0004 LC