PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Pdcd6 Rnf115 11591653 i2d,mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rab7a Rnf115 12972561 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Rnf115 17462600 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf115 Rnf115 17462600 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sssca1 Rnf115 11591653 i2d,mint,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atn1 Rnf115 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d3 Rnf115 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Akt1 Rnf115 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Myc Rnf115 ortho G G G G G G G G G G G G G G G G G G G G G Cst3 Rnf115 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d2b Rnf115 ortho G Ube2e3 Rnf115 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Herc2 Rnf115 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf115 Mfap4 ortho G G G G G G G G G G G Mdm4 Rnf115 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rab7b Rnf115 ortho G G G G G G G G G G G G G G G G G G G Rad23a Rnf115 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G App Rnf115 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2w Rnf115 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2i Rnf115 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf115 Dnajb2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Elavl1 Rnf115 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Egfr Rnf115 ortho G G G G G G G G G G G G G G G G G G Ttr Rnf115 ortho G G G G G G G G G G G G G G G G G G G G G G G Sfn Rnf115 ortho G G G G G G G G Ube2d1 Rnf115 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf115 Dazap2 ortho Rpl18a Rnf115 ortho Ywhab Rnf115 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2n Rnf115 ortho Cdk10 Rnf115 ortho Rnf115 Pfdn5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hras Rnf115 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d2 Rnf115 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2e1 Rnf115 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxw11 Rnf115 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dock4 Rnf115 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9D0C1 pull down 17462600 direct interaction X 2 Q9D0C1 P62837 pull down 17462600 direct interaction X 2 Q9D0C1 P61077-3 pull down 17462600 direct interaction X 2 Q9D0C1 P0CG50 enzymatic study 17462600 direct interaction X 2 Q9D0C1 P51150 protein complementation assay 12972561 direct interaction X 2 Q9D0C1 A0A024R2K3 pull down 17462600 direct interaction X 2 Q9D0C1 Q9D0C1 enzymatic study 17462600 direct interaction X 2 Q9D0C1 P12815 two hybrid array 11591653 physical association X 2 Q9D0C1 P56873 two hybrid array 11591653 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality UBC RNF115 17462600 0415 LC PDCD6 RNF115 11591653,11591653 0018,0397 HT RAB7A RNF115 12972561 0090 LC SSSCA1 RNF115 11591653,11591653 0018,0397 HT RNF115 RNF115 17462600 0415 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9D0C1 P56873 RNF115 SSSCA1 0.126 11591653 Q9D0C1 P12815 RNF115 PDCD6 0.126 11591653 Q9D0C1 P0CG50 RNF115 UBC 0.309 17462600 Q9D0C1 P51965 RNF115 UBE2E1 0.309 17462600 Q9D0C1 P61077 RNF115 UBE2D3 0.309 17462600 Q9D0C1 P62256 RNF115 UBE2H 0.309 17462600 Q9D0C1 P62837 RNF115 UBE2D2 0.309 17462600 Q9D0C1 Q9D0C1 RNF115 RNF115 0.332 17462600 Q9D0C1 P51150 RNF115 RAB7A 0.309 12972561