PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Pias3 Smap2 18413247 innatedb exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Ikzf1 15767674 intact exp G G G G G Pias3 Klf1 25713074 innatedb exp G G G G G G Pias3 Sumo1 12387893 innatedb,biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Rela 20211142,15155458 innatedb,biogrid,i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Mitf 20211142 biogrid,i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Stat3 9388184 innatedb exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Ube2i 12387893 innatedb,biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Gfi1 11060035,20211142 biogrid,i2d,intact exp, ortho G G G G G G Pias3 Tbp 16522640 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Irf1 12387893 innatedb,biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Serbp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Esr1 ortho G G G G G Pias3 Serpina10 ortho G G G G G G G Pias3 Uncharacterized protein C19orf60 homolog ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Ar ortho G G G G G G G G G G G G G G G G Pias3 Grm8 ortho G G G G G Pias3 Zfhx3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Trim27 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Zmiz1 ortho Pias3 Erbb4 ortho Pias3 Crebbp ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Elavl1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Stat5b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Hnrnpk ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Sept6 ortho G G G G G G G G G G G G G G G G Pias3 Ppp1ca ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Hic1 ortho G G G G G G G G G G G G G G G G G G G G G G Pias3 Sept8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Sumo2 ortho Pias3 Creb1 ortho G G G G G G G G G G G G G G G G G G G G G G Pias3 Nr3c2 ortho Pias3 Mbd1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Prpf40a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Siah2 ortho G G G G G G G G G G G G G G G G G G G G Pias3 Psmc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Ncoa2 ortho G G G G Pias3 Stat1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Stat5a ortho G G G G G G G G G G G G G G G G G G G G G G Pias3 Trim32 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Srebf2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Bcl11a ortho G G G G G G G G G G G G G G G G G G G Pias3 Satb1 ortho G G G G G G G G G G G G G G G G G G G G G G G Pias3 Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Esr2 Pias3 ortho G Pias3 Smad3 ortho G G G G G G G G G G G G G G G Pias3 Tab2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Smad2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Crem ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Uba1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Sept3 ortho G G G G G G G G G G G G G G G Pias3 Zmiz2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Habp4 ortho G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Grb2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Sumo3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Rac1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ep300 Pias3 ortho Pias3 Pias1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Gria1 ortho G G G G G G G G Pias3 Smad4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Wnk1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Gria2 ortho G G G G G G G G G Pias3 Trim63 ortho Pias3 Grik2 ortho G G G G Pias3 Skil ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Carhsp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Glul ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MCG19772, Protein Trim55 Pias3 ortho Pias3 Atf7ip ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias3 Pgr ortho G Pias3 Gem (Nuclear organelle) associated protein 4, Protein Gemin4 ortho Pias3 Trim8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hdac1 Pias3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O54714 P70338 pull down 11060035 direct interaction X 2 O54714 P70338 confocal microscopy 11060035 colocalization X 2 O54714 P70338 pull down 11060035 direct interaction X 2 O54714 P70338 two hybrid 11060035 physical association X 2 O54714 P70338 two hybrid 11060035 physical association X 2 O54714 P70338 pull down 11060035 direct interaction X 2 Q03267 O54714 anti bait coimmunoprecipitation 15767674 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Pias3 Irf1 MI:0018(two hybrid)|MI:0018(two hybrid) 12387893 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_321605|BIOGRID_321604 prey|prey bait|bait Pias3 Tbp MI:0018(two hybrid)|MI:0018(two hybrid) 16522640 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_326218|BIOGRID_326215 prey|prey bait|bait Pias3 Rela MI:0018(two hybrid) 20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_313532 prey bait Pias3 Ikzf1 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 15767674 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_80039|UniProt_163995 prey|prey bait|bait Pias3 Mitf MI:0018(two hybrid) 20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_313358 prey bait Pias3 Gfi1 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0018(two hybrid)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 11060035,20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0403(colocalization)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(intact)|(intact)|(biogrid)|(intact)|(intact)|(intact) UniProt_159932|UniProt_159931|UniProt_159930|BIOGRID_313121|UniProt_159935|UniProt_159934|UniProt_159933 prey|prey|prey|prey|neutral component|prey|bait bait|bait|bait|bait|neutral component|bait|prey

PPI - HINT Gene A Gene B PMID Method Quality PIAS3 IRF1 12387893,12387893 0018,0004 LC PIAS3 TBP 16522640,16522640 0018,0004 LC PIAS3 SUMO1 12387893 0018 LC PIAS3 UBE2I 12387893 0018 LC PIAS3 GFI1 11060035,11060035,11060035,20211142,11060035,11060035 0004,0663,0096,0018,0019,0018 LC,HT PIAS3 RELA 20211142,15140884,15140884,15140884,15140884 0018,0018,0019,0004,0045 HT,LC PIAS3 MITF 11709556,14645519,20211142,11709556,14645519,11709556 0004,0004,0018,0019,0019,0018 LC,HT PIAS3 IRF1 12387893,12387893 0018,0004 LC PIAS3 TBP 16522640,16522640 0018,0004 LC PIAS3 GFI1 11060035,11060035,11060035,11060035,11060035 0004,0663,0096,0019,0018 LC PIAS3 IKZF1 15767674 0006 LC PIAS3 RELA 15140884,15140884,15140884,15140884 0018,0019,0004,0045 LC PIAS3 MITF 11709556,14645519,11709556,14645519,11709556 0004,0004,0019,0019,0018 LC