PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ywhae Ubxn2b 16615898 intact exp G G G G G G G G G G G G G G G G G G Ubxn2b Usp14 11566882 biogrid exp G G G G G G G G G G G G G G G G G G Ubxn2b Kiaa1124 ortho Ubxn2b Aspscr1 ortho G G G G G G G G G G G G G G G G G G Meox1 Ubxn2b ortho G G G G G G G G G Ubxn2b Vat1l ortho Ubxn2b Ppp1r11 ortho G G G G G G G G G G G G G G G G G G Ubxn2b Actr6 ortho G G G G G G G G G G G G G G G G G G Ubxn2b Inca1 ortho G G G Ubxn2b Fank1 ortho G G Ubxn2b Ppp1r7 ortho G G G G G G G G G G G G G G G G G G Ubxn2b Ngly1 ortho G G G G G G G G G G G G G G G G G G Vcp Ubxn2b ortho G G G G G G G G G G G G G G G G G G Ubxn2b Vcpip1 ortho Crx Ubxn2b ortho Ubxn2b Nif3l1 ortho G G G G G G G G G G G G G G G G G G Ubxn2b Cog1 ortho G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q0KL01 E9PYI8 biochemical 11566882 colocalization X 2 P46462 Q0KL01 pull down 20691684 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Ubxn2b Usp14 MI:0027(cosedimentation)|MI:0401(biochemical) 11566882,16615898 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0403(colocalization) (intact)|(biogrid) UniProt_167114|BIOGRID_324256 neutral component|prey neutral component|bait

PPI - HINT Gene A Gene B PMID Method Quality YWHAE UBXN2B 16615898 0027 LC UBXN2B USP14 11566882 0401 LC UBXN2B USP14 11566882 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q0KL01 P46462 UBXN2B VCP 0.309 20691684 Q0KL01 P62259 UBXN2B YWHAE 0.081 16615898 Q9JMA1 Q0KL01 USP14 UBXN2B 0.126 11566882