PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Sdcbp Efnb3 9920925 mint,intact exp G G G G G G G G G Sdcbp Efnb1 9920925 i2d,mint,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Pdcd6ip 22660413 intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Ubc 21359963 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Unk 25737280 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Ulk1 i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Ldoc1 ortho Sdcbp Tmem239 ortho 4933404M02Rik Sdcbp ortho Sdcbp Cdipt ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Pde4dip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Rundc3a Sdcbp ortho G G G G G G G G G G G G Sdcbp Gria3 ortho P G G G G G G G G G G Sdcbp Clk2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Ric8a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Tgfa ortho G G G G G G G G G G G G G G G G G G G G G Sdcbp Tarsl2 ortho P Sdcbp Ctnnb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Cd63 ortho P Sdcbp Grm7 ortho Sdcbp Protein Trim38 ortho Sdcbp Sdc3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Mybpc2 ortho P Sdcbp Traf6 ortho G G G G G G G G G G G G G G G G G G G G Sdcbp Tdo2 ortho G G G Sdcbp Psmc6 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Hnrnpc ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Pstpip1 ortho G G G G G G G G G Sdcbp Cnot1 ortho P Sdcbp Hsbp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Trim27 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Cbr3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Grm4 ortho Sdcbp Smarca2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Ppp6r2 ortho P G G G G G G G G Sdcbp Eaf1 ortho Sdcbp Rnh1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Timm8b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Cep170 ortho Sdcbp Thg1l ortho Sdcbp Vcam1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Trim32 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Nagk ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Zbtb14 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Ropn1 ortho G G G Sdcbp Aes ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Gria4 ortho P G G G G Sdcbp Dtnbp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Pnma1 ortho Sdcbp Mad2l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Wdr91 ortho P Sdcbp Klhl12 ortho Sdcbp Lsm6 ortho P Sdcbp Klhl2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Ostf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Gnmt ortho P G G G G G G G G G Sdcbp Pts ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Set ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Edaradd ortho G G G G G Sdcbp Iars ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Srsf11 Sdcbp ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Sdc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Sdcbp ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Prpf40a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Mars ortho P Sdcbp Hprt1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Fzd8 ortho G G G G G G G G G G G G Sdcbp Gria1 ortho G G G G G G G G Sdcbp Aimp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Sept3 ortho P G G G G G G G G G G G G G G G G Sdcbp Ezh2 ortho G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Stx1a ortho G G G G G G G G G G G G G G G G G G G G G G Sdcbp Lztfl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Cadm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Zcchc17 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Nf2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Dak ortho P G G G G G G Sdcbp Gria2 ortho G G G G G G G G G Sdcbp Reep6 ortho GP G G G G G G G G G G G G G G G G G G Sdcbp Prpf38a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Cggbp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Nfasc ortho P Sdcbp Uncharacterized protein C1orf109 homolog ortho Sdcbp Cda ortho G G G G G G G G G G G G G G G G G Sdcbp Abi2 ortho Sdcbp Egfr ortho GP G G G G G G G G G G G G G G G G G Sdcbp Il5ra ortho G G Sdcbp Grm2 ortho Sdcbp Rbm39 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Cutc ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Cdcp1 ortho GP G G G G G G G G G G G G G G G G G Sdcbp Kctd9 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Lgals2 ortho GP G G G G G G G G G Sdcbp Fth1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Wrap73 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdccag3 Sdcbp ortho G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Eif5a2 ortho P Sdcbp Ankrd40 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Grik2 ortho G G G G Sdcbp Fam118b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Itga4 ortho G G G G Sdcbp Sult1b1 ortho P G G G G G Sdcbp Mid2 ortho G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Ltbr ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Clk3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Cox4i1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Necab2 ortho G G G G G G G G G G G G G G G G G Sdcbp Dctpp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Dmc1 ortho G Sdcbp Khdrbs2 ortho G G G G G Sdcbp Kcnh1 ortho G G G G G G G G G G G Samd1 Sdcbp ortho Sdcbp Kctd1 ortho G G G G G G G G G G G G G G G G G G G G G G Sdcbp Taok2 ortho Sdcbp Cmtm5 ortho Sdcbp Ube2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Tnfaip8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Puf60 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Lars ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Dctd ortho Sdcbp Ssna1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Kctd6 ortho Sdcbp Ccdc53 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Apip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Rtn1 ortho P G G G G G G G G G G G G G G G G G G G Sdcbp Elavl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Med4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Traf5 ortho G G G G G G G G G G G G G G G G G Sdcbp Enox1 ortho Sdcbp Phc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Hist1h2bc, Hist1h2be, Hist1h2bg ortho P Sdcbp Mbd3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Nt5c2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Hivep1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Homez ortho Sdcbp Ankrd28 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Src ortho G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Lmna ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Sox4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pten Sdcbp ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Ptprj ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Aim2 ortho G G Sdcbp Grm6 ortho Sdcbp Srsf7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Fzd7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Rel ortho G G G G Sdcbp Aimp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Eprs ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Sdcbp2 ortho GP G G G G G G G G Sdcbp Fam118a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Cd6 ortho G G Sdcbp Mapre3 ortho P G G G G G G G G G G G G G G G G G G G G G G Sdcbp Grik1 ortho G G G G G Sdcbp Nadk ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Pnma2 ortho Sdcbp Zbtb8a ortho G G G G G G G G G G G G G G G G G G Sdcbp Rab5a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Cep55 ortho G G G G G G G G G G G G G Sdcbp Tfcp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sclt1 Sdcbp ortho G G G G Sdcbp Fzd3 ortho G G G G G G G Sdcbp Sdc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Efnb2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Hoxa1 ortho G Sdcbp Pycrl ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Sdc4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Gpr37 ortho G G G G G G G G G Sdcbp Bles03 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Ephb2 ortho G G G G G G G G G G G G Sdcbp Flad1 ortho Sdcbp Lgals8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Bcl2l15 ortho G G G G G G Sdcbp Tifa ortho G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Trim54 ortho G G G G G G G Sdcbp Slc6a5 ortho G G Sdcbp Mtus2 ortho Sdcbp Coiled-coil domain containing 95, isoform CRA_g, INO80 complex subunit E, Protein Ino80e ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Eef1e1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Cadps ortho P G G G G G G G G G Sdcbp Gpatch11 ortho Sdcbp Dars ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Tspan3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Grm3 ortho Sdcbp Eif1ad ortho P Sdcbp Tekt1 ortho G G G G G Sdcbp Rars ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Ikzf1 ortho P G G G G G Sdcbp Ccdc36 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O08992 Q9WU78 two hybrid 22660413 physical association X 2 O08992 Q9WU78 two hybrid 22660413 physical association X 2 O08992 Q9WU78 two hybrid 22660413 physical association X 2 O08992 O35393 lambda phage display 9920925 physical association X 2 O08992 P52795 anti bait coimmunoprecipitation 9920925 physical association X 2 O08992 P52795 pull down 9920925 physical association X 2 O08992 P52795 fluorescence polarization spectroscopy 9920925 direct interaction X 2 O08992 P34901 two hybrid pooling approach 10911369 physical association X 2 O08992 P30203 two hybrid pooling approach 16034076 physical association X 2 O08992 P30203 pull down 16034076 physical association X 2 O08992 P30203 anti bait coimmunoprecipitation 16034076 physical association X 2 O08992 P30203 two hybrid array 16034076 physical association X 2 O08992 P98172 two hybrid 9883737 physical association X 2 O08992 P54759 two hybrid 9883737 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Sdcbp Ubc MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21359963 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_319139|BIOGRID_319140 prey|bait bait|prey Sdcbp Efnb1 MI:0066(lambda phage display)|MI:0066(lambda phage display)|MI:0066(lambda phage display)|MI:0053(fluorescence polarization spectroscopy)|MI:0053(fluorescence polarization spectroscopy)|MI:0053(fluorescence polarization spectroscopy) 9920925 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|(intact) MINT_77998|MINT_77995|MINT_77996|UniProt_177833|UniProt_177832|UniProt_177831 prey|bait|neutral component|bait|prey|neutral component bait|prey|neutral component|prey|bait|neutral component Sdcbp Efnb3 MI:0053(fluorescence polarization spectroscopy)|MI:0066(lambda phage display) 9920925 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint) UniProt_177834|MINT_77993 prey|prey bait|bait

PPI - HINT Gene A Gene B PMID Method Quality SDCBP EFNB3 9920925 0066 LC SDCBP ULK1 15014045,15014045 0007,0018 LC SDCBP UBC 21359963,21359963 0018,0004 LC SDCBP EFNB1 9920925,9920925,9920925,9920925,9920925,9920925,9920925 0045,0004,0053,0006,0019,0405,0096 LC SDCBP PDCD6IP 22660413 0018 LC SDCBP ULK1 15014045,15014045 0007,0018 LC SDCBP UBC 21359963,21359963 0018,0004 LC SDCBP EFNB1 9920925,9920925,9920925,9920925,9920925,9920925,9920925 0045,0004,0053,0006,0019,0405,0096 LC