PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Sh3gl2 Park2 20064468 biogrid exp G G G Ubc Sh3gl2 20064468 biogrid exp GP G G G G G G G G G G G G G G G G G G G G Ywhaz Sh3gl2 19562802 intact exp GP G G G G G G G G G G G G G G G G G G G G Dlg4 Sh3gl2 19455133 intact exp P G G G G G G G G G G Drd2 Sh3gl2 20551902 biogrid exp G G G G G Rasd1 Sh3gl2 21247419 intact exp G G G G G G G G G G G G G G Ywhae Sh3gl2 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G Sh3gl2 Dennd1a 17182770 mint,intact exp G G G G G G G G G G G G G G G G G G G Htt Sh3gl2 12456676 biogrid exp GP G G G G G G G G G G G G G G G G G G G G Syn1 Sh3gl2 12456676 biogrid exp P G G G G G G G G G G Sh3gl2 Amph 12456676 biogrid,i2d exp, ortho P G G G G G G G G G Atxn2 Sh3gl2 18602463 biogrid,mint,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G Bin1 Sh3gl2 12456676 biogrid,i2d exp, ortho GP G G G G G G G G G G G G G G G G G G G Sh3gl2 Pdcd6ip 12034747 mint,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G Adam9 Sh3gl2 10531379 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G Sh3gl2 Synj1 18093523,12456676,20064468 biogrid,i2d exp, ortho P Sh3gl2 Sh3kbp1 20551902 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G Adam15 Sh3gl2 10531379 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G Sh3gl2 Sh3gl2 18940612 i2d,dip exp, ortho GP G G G G G G G G G G G G G G G G G G G G Dnm1 Sh3gl2 12456676,22167186,16319076 biogrid,i2d,mint,intact exp, ortho GP G G G G G G G G G G G G G G G G G Sh3gl2 Zfp219 ortho G G G G G G G G G G G G G G G G G G G G G Sh3gl2 Dnm3 ortho P G G G G G G G G G G G G G H2-Aa Sh3gl2 ortho GP G G G G G G G G G G G G G G G G G G G Sh3gl2 Itsn1 ortho GP G G G G G G G G G G G G G G G G G Sh3gl2 Prr14 ortho G G G G G G G G G G G G G G G G G G G G G Dlgap4 Sh3gl2 ortho GP G G G G G G G G G G G G G G G G G G G G Dpysl4 Sh3gl2 ortho G G G G G G G G G G Tmem8b Sh3gl2 ortho Sh3gl2 Tmem108 ortho Sh3gl2 Dppa4 ortho Adam19 Sh3gl2 ortho G G G G G G G G G G G G G G G App Sh3gl2 ortho GP G G G G G G G G G G G G G G G G G G G G Sh3gl2 Ptpn23 ortho GP G G G G G G G G G G G G G G G G Mast2 Sh3gl2 ortho G G G G G G G G G G G G G G G G G G G G G Vwa5b2 Sh3gl2 ortho Terf1 Sh3gl2 ortho G G G G G G G G G G G G G G G G G G G Cbl Sh3gl2 ortho G G G G G G G G G G G G G G G G G G G G G Sh3gl2 Sh3gl3 ortho G G G G G G G G G G Sh3gl2 Scyl1 ortho GP G G G G G G G G G G G G G G G G G G G G Sh3gl2 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G Sh3gl2 C8g ortho G G Acta1 Sh3gl2 ortho GP G G G G G G G G G G G G G G G G G Sh3gl2 Asap1 ortho GP G G G G G G G G G G G G G G G G G G G Sh3gl2 Egfl6 ortho G G G G G Sh3gl2 F13a1 ortho GP G G G G G G G G G G G G Gch1 Sh3gl2 ortho P G G G G G G G G G G G G Dyrk1a Sh3gl2 ortho GP G G G G G G G G G G G G G G G G G G G G Sh3gl2 Znf580 ortho Slc17a7 Sh3gl2 ortho Sh3gl2 Ipo11 ortho GP G G G G G G G G G G G G G G G G G G G G Sh3gl2 Srgap3 ortho G G G G G G G G G G G G G G G G Sh3gl2 Diras1 ortho P G G G G G G G G Lrrk2 Sh3gl2 ortho GP G G G G G G G G G G G G G G Sh3gl2 Zxdc ortho G G G G G G G G G G G G G G G G G G G G G Sh3gl2 Ppp6r1 ortho P Sh3gl2 Synm ortho P Clec3b Sh3gl2 ortho GP G G G G G Gstm5 Sh3gl2 ortho GP G G G G G G G G G G G G G G G G G G G G Sh3gl2 Pak2 ortho GP G G G G G G G G G G G G G G G G G G G G Actg1 Sh3gl2 ortho GP G G G G G G G G G G G G G G G G G G G G Lcp2 Sh3gl2 ortho G G G G G G G Sh3gl2 Dact1 ortho G G G G G G G G G G G G G G G G G G G G G Sh3gl2 Itch ortho GP G G G G G G G G G G G G G G G G G G G G Tango2 Sh3gl2 ortho GP G G G G G G G G G G G G G G G G G G G G Cblb Sh3gl2 ortho Sh3gl2 Reps2 ortho P Il6 Sh3gl2 ortho P Sh3gl2 Fam102a ortho G G G G G G G G G G G G G G G G G G G G G Sh3gl1 Sh3gl2 ortho GP G G G G G G G G G G G G G G G G G G G G Emd Sh3gl2 ortho GP G G G G G G G G G G G G G G G G G G G G Sh3gl2 Tcea2 ortho G G G G G G G G G G G G G Adrb1 Sh3gl2 ortho G G G G G G G G Arnt2 Sh3gl2 ortho G G G G Sh3gl2 Phf2 ortho G G G G G G G G G G G G G G G G G G G G G Tyms Sh3gl2 ortho G Egfr Sh3gl2 ortho GP G G G G G G G G G G G Ppp1r21 Sh3gl2 ortho GP G G G G G G G G G G G G G G G G G G G G Dnm2 Sh3gl2 ortho GP G G G G G G G G G G G G G G G G G G G G Sh3gl2 Tiam2 ortho G G G G G G G G G G G Erh Sh3gl2 ortho P Sh3gl2 Map4k3 ortho G G G G G G G G G G G G G G G G G G G G G Protein Raph1 Sh3gl2 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O08539 Q62420 - 12456676 - X 2 Q62420 - 12456676 - X 2 Q7TQF7 Q62420 - 12456676 - X 2 Q62420 Q62420 - 16023669 - X 2 O88935-1 Q62420 - 12456676 - X 2 Q62420 Q8CHC4 - 12456676 - X 2 Q62420 affinity chromatography technology 18602463 physical association X 2 Q62420 affinity chromatography technology 18602463 physical association X 2 Q62420 P39053 affinity chromatography technology 22167186 physical association X 2 Q62420 D3Z656 affinity chromatography technology 18093523 physical association X 2 Q62420 P0CG50 affinity chromatography technology 20064468 physical association X 2 Q62420 D3Z656 pull down 20064468 direct interaction X 2 Q62420 D3Z656 affinity chromatography technology 20064468 physical association X 2 Q62420 D3Z656 pull down 20064468 direct interaction X 2 Q9WVS6 Q62420 affinity chromatography technology 20064468 physical association X 2 Q9WVS6 Q62420 affinity chromatography technology 20064468 physical association X 2 Q9WVS6 Q62420 affinity chromatography technology 20064468 physical association X 2 Q9WVS6 Q62420 x-ray crystallography 20064468 association X 2 Q9WVS6 Q62420 x-ray crystallography 20064468 association X 2 Q9WVS6 Q62420 pull down 20064468 direct interaction X 2 Q9WVS6 Q62420 enzymatic study 20064468 direct interaction X 2 Q62420 B4DJ51 affinity chromatography technology 16512683 physical association X 2 Q62420 Q62420 x ray scattering 18940612 direct interaction Y 1 Q62420 Q62420 molecular sieving 18940612 direct interaction Y 1 Q62420 cosedimentation in solution 19562802 association C 137 Q62420 affinity chromatography technology 16512683 association C 138 Q62420 anti tag coimmunoprecipitation 19455133 association C 226 O35626 Q62420 two hybrid 21247419 physical association X 2 P39053-4 Q62420 peptide array 16319076 direct interaction X 2 O70305 Q62420 anti bait coimmunoprecipitation 18602463 physical association X 2 Q62420 Q9WU78 two hybrid 12034747 physical association X 2 Q62420 Q9WU78 imaging technique 12034747 colocalization X 2 Q62420 P21575 pull down 16606361 physical association X 2 O88839 Q62420 coimmunoprecipitation 10531379 physical association X 2 Q62634 Q62420 pull down 16606361 physical association X 2 Q99700 Q62420 pull down 18602463 physical association X 2 Q61072 Q62420 coimmunoprecipitation 10531379 physical association X 2 Q8K382 Q62420 pull down 17182770 physical association X 2 Q8K382 Q62420 anti bait coimmunoprecipitation 17182770 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Adam15 Sh3gl2 MI:0018(two hybrid)|MI:0027(cosedimentation) 10531379,16615898 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0403(colocalization) (intact)|(intact) UniProt_159888|UniProt_167114 prey|neutral component bait|neutral component Dnm1 Sh3gl2 MI:0028(cosedimentation in solution)|MI:0028(cosedimentation in solution)|MI:0027(cosedimentation)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0027(cosedimentation) 10,16319076,16615898,19562802,22167186 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0914(association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0403(colocalization) (intact)|(intact)|(intact)|(biogrid)|(intact)|MI:0471(mint)|MI:0471(mint)|(intact) UniProt_170828|UniProt_101549|UniProt_167117|BIOGRID_320692|UniProt_166179|MINT_71640|MINT_71631|UniProt_167114 neutral component|neutral component|neutral component|bait|null|null|null|neutral component neutral component|neutral component|neutral component|prey|prey|bait|prey|neutral component Rasd1 Sh3gl2 MI:0006(anti bait coimmunoprecipitation) 21247419 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_172347 bait prey Adam9 Sh3gl2 MI:0018(two hybrid) 10531379 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_159887 prey bait Ubc Sh3gl2 MI:0004(affinity chromatography technology) 20064468 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_316285 prey bait Atxn2 Sh3gl2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 10,18602463 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|MI:0471(mint)|(intact) BIOGRID_320625|BIOGRID_320626|MINT_74931|UniProt_169777 prey|bait|prey|prey bait|prey|bait|bait Sh3gl2 Dennd1a MI:0096(pull down)|MI:0096(pull down) 17182770 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_167451|UniProt_167455 bait|prey prey|bait Sh3gl2 Synj1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18093523,20064468 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_325474|BIOGRID_316290|BIOGRID_316287|BIOGRID_316286 bait|prey|prey|bait prey|bait|bait|prey Sh3gl2 Pdcd6ip MI:0018(two hybrid)|MI:0018(two hybrid) 12034747 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0915(physical association) (intact)|(intact) UniProt_160919|UniProt_160917 unspecified role|prey unspecified role|bait Sh3gl2 Sh3gl2 MI:0826(x ray scattering) 18940612 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) MI:0465(dip) DIP_579 - -

PPI - HINT Gene A Gene B PMID Method Quality BIN1 SH3GL2 12456676,12456676,12456676 0004,0096,0047 LC RASD1 SH3GL2 21247419 0018 LC ADAM15 SH3GL2 10531379 0019 LC SYN1 SH3GL2 12456676,12456676,12456676 0004,0096,0047 LC DNM1 SH3GL2 12456676,16319076,12456676,12456676 0004,0081,0047,0096 LC YWHAE SH3GL2 16615898 0027 LC YWHAZ SH3GL2 19562802 0028 LC ADAM9 SH3GL2 10531379 0019 LC SH3GL2 SH3GL2 18940612,18940612,16023669 0826,0071,0114 LC SH3GL2 AMPH 12456676,12456676,12456676 0004,0096,0047 LC SH3GL2 SYNJ1 12456676,12456676,12456676 0096,0004,0047 LC SH3GL2 PDCD6IP 12034747,12034747 0428,0018 LC SH3GL2 PARK2 20064468,20064468,20064468,20064468 0415,0096,0004,0114 LC BIN1 SH3GL2 12456676,12456676,12456676 0004,0096,0047 LC ATXN2 SH3GL2 18602463,18602463 0004,0006 LC SYN1 SH3GL2 12456676,12456676,12456676 0004,0096,0047 LC UBC SH3GL2 20064468 0004 LC DNM1 SH3GL2 12456676,22167186,12456676,12456676 0004,0004,0047,0096 LC HTT SH3GL2 12456676 0096 LC DRD2 SH3GL2 20551902 0004 LC DLG4 SH3GL2 19455133 0007 LC SH3GL2 AMPH 12456676,12456676,12456676 0004,0096,0047 LC SH3GL2 SYNJ1 18093523,20064468,12456676,12456676,20064468,12456676 0004,0004,0096,0004,0096,0047 LC SH3GL2 DENND1A 17182770,17182770 0096,0006 LC SH3GL2 SH3KBP1 20551902 0004 LC SH3GL2 PDCD6IP 12034747,12034747 0428,0018 LC SH3GL2 PARK2 20064468,20064468,20064468,20064468 0415,0096,0004,0114 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q62420 P61168 SH3GL2 DRD2 0.21 20551902 Q62420 P62259 SH3GL2 YWHAE 0.081 16615898 Q9WU78 Q62420 PDCD6IP SH3GL2 0.396 12034747 Q62420 Q62108 SH3GL2 DLG4 0.236 19455133 Q62420 O88935 SH3GL2 SYN1 0.309 12456676 Q62420 O70305 SH3GL2 ATXN2 0.507 18602463 Q62420 O08539 SH3GL2 BIN1 0.309 12456676 Q62420 O35626 SH3GL2 RASD1 0.309 21247419 Q62420 P0CG50 SH3GL2 UBC 0.21 20064468 Q62420 P39053 SH3GL2 DNM1 0.623 22167186,12456676,16319076 Q99700 Q62420 ATXN2 SH3GL2 0.21 18602463 Q7TQF7 Q62420 AMPH SH3GL2 0.309 12456676 Q8R550 Q62420 SH3KBP1 SH3GL2 0.21 20551902 Q62634 Q62420 SLC17A7 SH3GL2 0.21 16606361 Q8K382 Q62420 DENND1A SH3GL2 0.376 17182770 Q62420 Q62420 SH3GL2 SH3GL2 0.554 18940612 Q62420 P62158 SH3GL2 CALM3 0.236 16512683 Q9WVS6 Q62420 PARK2 SH3GL2 0.858 20064468 Q62420 P63101 SH3GL2 YWHAZ 0.126 19562802 Q62420 P21575 SH3GL2 DNM1 0.21 16606361