PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Eed Ube4b 24457600 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Itpr1 Ube4b 16103111 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube4b Ube4b 11435423,23509263 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vcp Ube4b 12504083,15189447,22174917,10811609 biogrid,i2d,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hdlbp Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Zfyve19 Ube4b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2v1 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Xpc Ube4b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ttc9c Ube4b ortho Ttc4 Ube4b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube4b Ndufa7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pcid2 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vav2 Ube4b ortho G Ube4b Vps29 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc27 Ube4b ortho G G G G G G Ufd1l Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ndufa2 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp34 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vps4b Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Elavl1 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d2 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sco2 Ube4b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nusap1 Ube4b ortho G G G G G G G G G G G G G G G G G Nf2 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nsfl1c Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubxn7 Ube4b ortho P Ube4b Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube4b Abcb10 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Igbp1 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G Usp9x Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d1 Ube4b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube4b Dnajb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube4b Pde3a ortho G G G G Sbds Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube4b Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Foxk1 Ube4b ortho P G G G Nploc4 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbl Ube4b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rbm12 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2l3 Ube4b ortho P Ube4b Trip6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube4b Dnajc7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vps35 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspa9 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atxn3 Ube4b ortho P Fbxw11 Ube4b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube4b Uchl3 ortho P Esr1 Ube4b ortho G G G G G Sf3b4 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sssca1 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tp63 Ube4b ortho G G G G G G G Ube4b Tp73 ortho G Psmb1 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ahcyl1 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube4b Mad2l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Supt6h Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2c Ube4b ortho G G G G G G G G G G G G G G G G G G Yod1 Ube4b ortho Ufm1 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Trip12 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rad23b Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ttk Ube4b ortho G G G G G G G G Uba6 Ube4b ortho P Ube2d3 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Thy1 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Casp6 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Tp53 Ube4b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubxn1 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Trub2 Ube4b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm2 Ube4b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubqln1 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vps36 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vps26a Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Egfr Ube4b ortho GP G G G G G G G G G G G G G G G G G Zpr1 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hrsp12 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ntrk1 Ube4b ortho Btrc Ube4b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mrpl53 Ube4b ortho P Fez1 Ube4b ortho G G G G G G G G G G G G G G G G G Ube4b Dnaja2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hgs Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stk16 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Srprb Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nudcd3 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Casp3 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube4b Gyg1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubl7 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atp6v1f Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sarnp Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdkn2a Ube4b ortho Hspa4 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rad23a Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppif Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Casp7 Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants B2RSC8 Q9ES00 enzymatic study 11435423 direct interaction X 2 P11881 Q9ES00 affinity chromatography technology 16103111 physical association X 2 Q9ES00 P0CG50 affinity chromatography technology 11435423 physical association X 2 Q9ES00 Q9ES00 enzymatic study 11435423 direct interaction X 2 Q9ES00 P0CG50 enzymatic study 11435423 direct interaction X 2 Q9ES00 Q9ES00 enzymatic study 23509263 direct interaction X 2 Q9ES00 P61077-3 pull down 23509263 direct interaction X 2 Q9ES00 Q96FI0 pull down 23509263 direct interaction X 2 Q9ES00 Q921E6 affinity chromatography technology 24457600 physical association X 2 Q01853 Q9ES00 affinity chromatography technology 22174917 physical association X 2 Q01853 Q9ES00 affinity chromatography technology 10811609 physical association X 2 Q01853 Q9ES00 affinity chromatography technology 15189447 physical association X 2 Q01853 Q9ES00 affinity chromatography technology 15189447 physical association X 2 Q01853 Q9ES00 affinity chromatography technology 12504083 physical association X 2 Q01853 Q9ES00 coimmunoprecipitation 12504083 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality VCP UBE4B 12504083,12504083 0019,0004 LC UBE4B UBE4B 23509263,11435423 0415,0415 LC ITPR1 UBE4B 16103111 0004 LC VCP UBE4B 22174917,12504083,12504083,15189447,10811609 0004,0019,0004,0004,0004 LC EED UBE4B 24457600 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9ES00 P11881 UBE4B ITPR1 0.21 16103111 Q9ES00 Q9ES00 UBE4B UBE4B 0.554 11435423,23509263 Q9ES00 P61077 UBE4B UBE2D3 0.523 23509263,11435423 Q9ES00 Q01853 UBE4B VCP 0.692 15189447,22174917,12504083,10811609 Q9ES00 Q921E6 UBE4B EED 0.126 24457600 Q9ES00 Q96B02 UBE4B UBE2W 0.309 23509263