PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ywhae Gnb1 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Dlg4 19455133 intact exp P G G G G G G G G G G Pou5f1 Gnb1 22083510 biogrid exp Gnb1 Hsd3b4 16615898 intact exp Gnb1 Grin2b 16635246 intact exp G G G G G Gnb1 Vamp2 20114047 biogrid,intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dync1i1 Gnb1 12359736 biogrid exp P G G G G G G G G G G G Gnb1 Ywhaz 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prnp Gnb1 15146195 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Aph1a 15146195 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Aph1b 15146195 biogrid exp Cav3 Gnb1 8663016 biogrid exp G G G G Rasd1 Gnb1 21247419 intact exp, ortho G G G G G G G G G G G G G G G G Gnb1 Gnai3 i2d exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnao1 Gnb1 8550614 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G Gnb1 Gng2 8550614 biogrid exp, ortho G G G G G G G G G G G G G G Btk Gnb1 7972043 biogrid exp, ortho G G G G G Gnb1 Gnb2l1 12359736 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Adrbk1 7972043 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gng11 Gnb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Hdac4 ortho Slc2a4 Gnb1 ortho G G G G G G G G G G G G G G G G G G G G Gnai1 Gnb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Pdlim7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Ntn1 Gnb1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Gng13 ortho G G G G G G G Gnb1 Disc1 ortho Gng4 Gnb1 ortho G G G G G G G Gna12 Gnb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Rasd2 ortho G G G G G G G G G G G G G Gnb1 Flad1 ortho Gnb1 Mtnr1a ortho Gnb1 Gnas ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnaq Gnb1 ortho GP G G G G G G G G G G G G G Gnb1 Rgs6 ortho Fyn Gnb1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pth1r Gnb1 ortho G G G G G G G G G G G G Gnb1 Arhgef18 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Wdr26 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Spag1 ortho G G G G G G G G Gnb1 Gng7 ortho Akt1 Gnb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atxn10 Gnb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Radil ortho Kalrn Gnb1 ortho G G G G Gnb1 Hspa8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ccdc8 Gnb1 ortho Gnb1 Mcf2l ortho Abce1 Gnb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Cacna1c ortho G G G G G G G G G G G G Gnb1 Synpo ortho P G G G G G G G G G G G G G G G G G G G G G Gnb1 Mtnr1b ortho Gnb1 Nudcd3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vcam1 Gnb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Gng3 ortho G G G G G G G G G G G G G G Gnb1 Gngt1 ortho G Gnb1 Erbb2 ortho P G G G G G G G G G G G G Gnb1 Hdac5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Mcc ortho Gnb1 Cytoplasmic FMR1-interacting protein 1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Cdc42bpa ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Mrgprb2 ortho Htt Gnb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Map3k3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Elavl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nr3c1 Gnb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Pan2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Cct5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Pfdn5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Kcnj3 ortho G G G G G G G G G G G G Gnb1 Aarsd1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cacna1b Gnb1 ortho G G G G G Ncf2 Gnb1 ortho G G G G G G G G G G G G G G G G G G G G Protein Mcf2 Gnb1 ortho G G Ptk2 Gnb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Gng10 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Esr1 Gnb1 ortho G G G G G Gnb1 Cacna1a ortho G G G G G G Gnb1 Gngt2 ortho P Gnb1 Mtor ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cox4i1 Gnb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnai2 Gnb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Sumo3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Psmd2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Jun Gnb1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rap1a Gnb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Afp Gnb1 ortho G G G G G Gnb1 Stip1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Epha7 ortho G G G G Gnb1 Plekhg2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 ATPase, H+ transporting, lysosomal V1 subunit B1, ATPase, H+ transporting, lysosomal V1 subunit B1, isoform CRA_a, Protein Atp6v1b1, Vacuolar proton translocating ATPase B1 isoform ortho P G G G G Cd247 Gnb1 ortho G G G Gnb1 Rictor ortho P Tbxa2r Gnb1 ortho G G G G G G G G G G G G G G G G G G G G G G Atp6v1a Gnb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Gng12 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Mlf1 ortho G G G G G G G G G G G Gnb1 Cep128 ortho Gnb1 Ripk3 ortho G G G G G G G G G G G Gnb1 Wasf1 ortho GP G G G G G G G G G G G G G G G G Gnb1 Nol11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Ntrk1 ortho Gnb1 Vav3 ortho G G G G G G G G G G G G G G G G G Gnb1 Mlf2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Tekt2 ortho G G G Gnb1 Pdcl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Ubqln1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Svil ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Gnb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gna11 Gnb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Arrb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Adrb2 Gnb1 ortho G G G G G G G G G Snca Gnb1 ortho P G G G G G G G G G G G G G G G G Avpr2 Gnb1 ortho G G G Nfx1 Gnb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Adra2a ortho G G G G Gnb1 Xpo1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb1 Rptor ortho P Gnb1 Gng8 ortho

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Btk Gnb1 MI:0004(affinity chromatography technology) 7972043 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_328143 bait prey Dync1i1 Gnb1 MI:0096(pull down)|MI:0027(cosedimentation)|MI:0027(cosedimentation) 12359736,16615898 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0403(colocalization)|MI:0403(colocalization) (biogrid)|(intact)|(intact) BIOGRID_322650|UniProt_167115|UniProt_167116 prey|neutral component|neutral component bait|neutral component|neutral component Prnp Gnb1 MI:0004(affinity chromatography technology) 15146195 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_323283 bait prey Gnb1 Gnb2l1 MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0096(pull down)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation) 12359736,16615898 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0915(physical association)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization) (intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(biogrid)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact) UniProt_167131|UniProt_167121|UniProt_167132|UniProt_167117|UniProt_167133|UniProt_167136|UniProt_167123|UniProt_167119|BIOGRID_322649|UniProt_167134|UniProt_167124|UniProt_167128|UniProt_167115|UniProt_167135|UniProt_167116 neutral component|neutral component|neutral component|neutral component|neutral component|neutral component|neutral component|neutral component|bait|neutral component|neutral component|neutral component|neutral component|neutral component|neutral component neutral component|neutral component|neutral component|neutral component|neutral component|neutral component|neutral component|neutral component|prey|neutral component|neutral component|neutral component|neutral component|neutral component|neutral component Gnb1 Adrbk1 MI:0004(affinity chromatography technology) 7972043 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_328142 prey bait Gnb1 Gng2 MI:0096(pull down) 8550614 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_328162 bait prey Pou5f1 Gnb1 MI:0004(affinity chromatography technology) 22083510 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_320922 bait prey Cav3 Gnb1 MI:0401(biochemical) 8663016 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization) (biogrid) BIOGRID_325420 bait prey Gnao1 Gnb1 MI:0096(pull down)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation) 16615898,8550614 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization) (biogrid)|(intact)|(intact)|(intact)|(intact)|(intact) BIOGRID_328163|UniProt_167131|UniProt_167132|UniProt_167117|UniProt_167115|UniProt_167116 prey|neutral component|neutral component|neutral component|neutral component|neutral component bait|neutral component|neutral component|neutral component|neutral component|neutral component Gnb1 Aph1a MI:0004(affinity chromatography technology) 15146195 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_323261 prey bait Gnb1 Aph1b MI:0004(affinity chromatography technology) 15146195 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_323272 prey bait Rasd1 Gnb1 MI:0006(anti bait coimmunoprecipitation) 21247419 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_172345 bait prey

PPI - HINT Gene A Gene B PMID Method Quality RASD1 GNB1 21247419 0018 LC OPRD1 GNB1 9190886 0019 LC CAV3 GNB1 8663016 0401 LC YWHAE GNB1 16615898 0027 LC GNB1 YWHAZ 16615898 0027 LC GNB1 HSD3B4 16615898 0027 LC GNB1 GNAI3 16009138 0019 LC DYNC1I1 GNB1 12359736 0004 LC PRNP GNB1 15146195 0004 LC GNAO1 GNB1 8550614 0096 LC POU5F1 GNB1 22083510 0004 LC BTK GNB1 7972043 0004 LC CAV3 GNB1 8663016 0401 LC GNB1 VAMP2 20114047,20114047 0004,0006 LC GNB1 GNG2 8550614 0096 LC GNB1 RACK1 12359736 0004 LC GNB1 GRIN2B 16635246 0004 HT GNB1 SHANK3 27507650 0004 LC GNB1 DLG4 27507650,19455133 0004,0007 LC GNB1 APH1A 15146195 0004 LC GNB1 APH1B 15146195 0004 LC GNB1 ADRBK1 7972043 0004 LC GNB1 DLGAP1 27507650 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P62874 O43306 GNB1 ADCY6 0.309 17110384 Q61767 P62874 HSD3B4 GNB1 0.081 16615898 P62874 P62259 GNB1 YWHAE 0.081 16615898 P62874 O35626 GNB1 RASD1 0.309 21247419 Q8BVF7 P62874 APH1A GNB1 0.126 15146195 Q8C7N7 P62874 APH1B GNB1 0.126 15146195 P62874 P04925 GNB1 PRNP 0.126 15146195 P62874 P37840 GNB1 SNCA 0.236 18614564 P62874 P10809 GNB1 HSPD1 0.236 26496610 P62874 P17987 GNB1 TCP1 0.236 26496610 P62874 P40227 GNB1 CCT6A 0.236 26496610 P62874 P48643 GNB1 CCT5 0.236 26496610 P62874 P49368 GNB1 CCT3 0.236 26496610 P62874 P50990 GNB1 CCT8 0.236 26496610 P62874 P50991 GNB1 CCT4 0.236 26496610 P78371 P62874 CCT2 GNB1 0.236 26496610 Q13371 P62874 PDCL GNB1 0.236 26496610 Q99832 P62874 CCT7 GNB1 0.236 26496610 Q9UBI6 P62874 GNG12 GNB1 0.236 26496610 P62874 O95622 GNB1 ADCY5 0.523 17110384 P63044 P62874 VAMP2 GNB1 0.236 20114047 Q99MK8 P62874 ADRBK1 GNB1 0.21 7972043 Q9D415 P62874 DLGAP1 GNB1 0.126 27507650 P62874 P35991 GNB1 BTK 0.21 7972043 P63213 P62874 GNG2 GNB1 0.309 8550614 P62874 P18872 GNB1 GNAO1 0.309 8550614 P62874 O88485 GNB1 DYNC1I1 0.21 12359736 P62874 O60925 GNB1 PFDN1 0.126 26496610 P62874 E5RGS4 GNB1 PFDN1 {ECO:0000313|ENSEMBL:ENSP00000428707} 0.126 26496610 Q62108 P62874 DLG4 GNB1 0.332 27507650,19455133 P68040 P62874 GNB2L1 GNB1 0.21 12359736 P63101 P62874 YWHAZ GNB1 0.081 16615898 Q01097 P62874 GRIN2B GNB1 0.126 16635246 P62874 P51637 GNB1 CAV3 0.126 8663016 P62874 P20263 GNB1 POU5F1 0.126 22083510 Q4ACU6 P62874 SHANK3 GNB1 0.126 27507650