PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Gsc2 Rnf4 10822263 biogrid exp, ortho Trps1 Rnf4 12885770 biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G Rnf4 Mecp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d1 Rnf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tardbp Rnf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d2 Rnf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf4 Rnf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Patz1, Transcription factor MAZR, Zinc finger protein 278, isoform CRA_d Rnf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Srpk2 Rnf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2e3 Rnf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Skil Rnf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d3 Rnf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hnf4a Rnf4 ortho G G G G G G G G G G G Ube2t Rnf4 ortho G G G G G G G G G G G G Creb1 Rnf4 ortho G G G G G G G G G G G G G G G G G G G G G G Ube2w Rnf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rnf169 Rnf4 ortho Pml Rnf4 ortho G G G G G G G G G G G G G G G G G G G G G Rnf4 Sart1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tcf20 Rnf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Apex1 Rnf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sumo2 Rnf4 ortho Ube2e2 Rnf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ikbkg Rnf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sumo1 Rnf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Rnf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pgr Rnf4 ortho G Parp1 Rnf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Uhrf1 Rnf4 ortho G G G G G G G G G G G G G Traip Rnf4 ortho G G G G G G G G Ube2h Rnf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Uevld Rnf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Esr1 Rnf4 ortho G G G G G Rnf4 Ube2l6 ortho G G G G G G G G G Trim28 Rnf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rpa1 Rnf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2i Rnf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2v1 Rnf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Uba1 Rnf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nfatc2ip Rnf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdc1 Rnf4 ortho Sp1 Rnf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hist1h4a, Hist1h4b, Hist1h4c, Hist1h4d, Hist1h4f, Hist1h4h, Hist1h4i, Hist1h4j, Hist1h4k, Hist1h4m, Hist2h4a, Hist4h4 Rnf4 ortho G G G G G G G G G G G G G G Ube2k Rnf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hist1h3b, Hist1h3c, Hist1h3d, Hist1h3e, Hist1h3f, Hist2h3b, Hist2h3c1, Hist2h3c2 Rnf4 ortho G G G G Ube2d2b Rnf4 ortho G Ube2n Rnf4 ortho Hist1h2ab, Hist1h2ac, Hist1h2ad, Hist1h2ae, Hist1h2ag, Hist1h2ai, Hist1h2an, Hist1h2ao Rnf4 ortho Ar Rnf4 ortho G G G G G G G G G G G G G G G G Nfe2l2 Rnf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atxn1 Rnf4 ortho Tbp Rnf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2e1 Rnf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P10275 Q9QZS2 - 9710597 - X 2 Q9QZS2 affinity chromatography technology 10822263 physical association X 2 Q9QZS2 affinity chromatography technology 10822263 physical association X 2 Q9QZS2 two hybrid 12885770 direct interaction X 2 Q9QZS2 P61956-2 enzymatic study 24912682 direct interaction X 2 P10275 Q9QZS2 two hybrid 9710597 - X 2

PPI - HINT Gene A Gene B PMID Method Quality TRPS1 RNF4 12885770 0018 LC RNF4 RNF4 20681948 0114 LC GSC2 RNF4 10822263 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9QZS2 Q925H1 RNF4 TRPS1 0.309 12885770 Q9QZS2 Q9QZS2 RNF4 RNF4 0.332 20681948 Q9QZS2 P61956 RNF4 SUMO2 0.309 24912682