PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ube2k Eed 24457600 innatedb,biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Ywhae 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Lrsam1 ortho P Wdr1 Ube2k ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Dtx3l ortho P Ube2k Iqcb1 ortho Ube2k Rps27a ortho P Ube2k Rnf111 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nfkb1 Ube2k ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rel Ube2k ortho G G G G Ube2k Nedd4l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Prpf40a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Cyhr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Rnf185 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k March7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Bag3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Mkrn3 ortho Rnf5 Ube2k ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Ube2k ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Mipol1 ortho P Ubc Ube2k ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Rnf167 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Ubox5 ortho GP G G G G G G G G G G G G G G G G G G G Ube2k Cblc ortho G G G G G G G G G G G G G G Ube2k Rnf114 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Uhrf2 ortho Ube2k Rnf138 ortho G G G G G G G G G G G G G G G Mdm2 Ube2k ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mocs3 Ube2k ortho P Ube2k Trim31 ortho G G G G G Ube2k March3 ortho Ube2k Trim39 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pcbp3 Ube2k ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc6 Ube2k ortho G G G G G G G G Ube2k Ppp2r1a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tyms Ube2k ortho G G Psmd4 Ube2k ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Pin1 ortho P Bard1 Ube2k ortho Ube2k Ube2v1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Wdr61 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Txndc17 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tp53 Ube2k ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Ube2d2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Ak2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Psmb2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Mkrn2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Itsn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Ube2k ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Amfr ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Nme2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Diablo ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Ube2n ortho P Birc7 Ube2k ortho Mid1 Ube2k ortho Ube2k Cops8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Htt Ube2k ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Rnf41 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Dstyk ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Ube2k ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Ddx58 ortho P Ube2k Tmem189 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Nxf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Sumo1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Dzip3 ortho Ube2k Rnf2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Cct7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Uba1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Pias4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k1 Ube2k ortho G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Ube3c ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Ube2i ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Traip ortho G G G G G G G G Ube2k Trim2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Bfar ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Txn Ube2k ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nub1 Ube2k ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Zdhhc17 ortho Ube2k Rab1A ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Itch ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmb8 Ube2k ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Rnf4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Ube2k ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Ddi1 ortho P Ube2k Dtx3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Rnf144a ortho G G G G G G G G G G G G G G G G Ube2k Trim27 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Abcd3 Ube2k ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Trim35 ortho G G G G G G G G G G G G G G G G G G G G G G G Brca1 Ube2k ortho G G G G G G G G G G G G G Ube2k Traf7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Senp1 Ube2k ortho G G G G G G G G G G G G G G G G G G G G G G G Ube2k Rnf32 ortho G G G G G G G G G G G G G G G G G G G G G Ube2k Ikbke ortho G G G G G G G G G G G G G Ube2k Prrg4 ortho Ube2k Rbck1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Anapc11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Trim3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P61087 Q921E6 affinity chromatography technology 24457600 physical association X 2 Q8WV22 P61087 pull down 22992278 direct interaction X 2 A0A024R206 P61087 pull down 22992278 direct interaction X 2 P61087 Q2KHN1 pull down 22992278 direct interaction X 2 P61087 enzymatic study 25260751 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Ube2k Eed MI:0004(affinity chromatography technology) 24457600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_332325 prey bait

PPI - HINT Gene A Gene B PMID Method Quality UBC UBE2K 25471371 0415 LC UBE2K YWHAE 16615898 0027 LC UBE2K EED 24457600 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P61087 B4DT77 UBE2K B4DT77 0.126 26496610 P61087 E9PJD7 UBE2K CYHR1 {ECO:0000313|ENSEMBL:ENSP00000433769} 0.126 26496610 P61087 P0CG50 UBE2K UBC 0.309 25471371 P61087 P20073 UBE2K ANXA7 0.126 26496610 Q6ZMK1 P61087 CYHR1 UBE2K 0.126 26496610 P62259 P61087 YWHAE UBE2K 0.081 16615898 Q9BVI0 P61087 PHF20 UBE2K 0.236 26496610 P61087 P11441 UBE2K UBL4A 0.236 26496610 Q96QC0 P61087 PPP1R10 UBE2K 0.236 26496610 Q15596 P61087 NCOA2 UBE2K 0.236 26496610 P61087 P22314 UBE2K UBA1 0.236 26496610 P61087 P47897 UBE2K QARS 0.236 26496610 Q86SQ7 P61087 SDCCAG8 UBE2K 0.236 26496610 Q29RF7 P61087 PDS5A UBE2K 0.236 26496610 Q63HN8 P61087 RNF213 UBE2K 0.236 26496610 Q9BXK1 P61087 KLF16 UBE2K 0.236 26496610 Q9UHX1 P61087 PUF60 UBE2K 0.236 26496610 Q8WV22 P61087 NSMCE1 UBE2K 0.309 22992278 Q921E6 P61087 EED UBE2K 0.126 24457600 Q9BV68 P61087 RNF126 UBE2K 0.309 22992278 Q2KHN1 P61087 RNF151 UBE2K 0.309 22992278