PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Lnx1 Scn5a 23022437 mint,intact exp G G G G G G G Lnx1 Ca1 12468544 biogrid exp G G Lnx1 Igsf5 16832352 biogrid exp, ortho G G G G G G G G G G Lnx1 Lnx1 9535908 biogrid,i2d exp, ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Cxadr 12468544 mint,intact exp, ortho G G G G G G G G G G G G G G G G G Lnx1 Lnx2 i2d exp, ortho G G G G G G G G G G G G G G G G G G G Lnx1 Numb 9535908 biogrid,i2d exp, ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Cldn1 19295125 biogrid exp, ortho G G G G G G G G G Lnx1 Erbb2 16122940 biogrid exp, ortho G G G G G G G G G Lnx1 Nxt2 ortho Lnx1 Aida ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Zbtb8b ortho Lnx1 Dnpep ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Sat1 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Trim39 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Sncb ortho G G G G G G G G G G G G G G G G G Lnx1 Gpr142 ortho Lnx1 Gdi1 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Ssna1 ortho G G G G G G G G G G G G G G G G G G G G Akirin2 Lnx1 ortho Lnx1 Mtus2 ortho Lnx1 Mettl21A ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Slc6a15 ortho G G G G G G G G G G Lnx1 Cdc42ep4 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Pdzrn3 ortho G G G G G G G G G G G G G G G G G G Aurkb Lnx1 ortho G G G G G G Lnx1 E4f1 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Tbcel ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Tyro3 ortho G G G G G G G G G G G Lnx1 Arvcf ortho G G G G G G G G G G Lnx1 Gipr ortho Lnx1 Grin1 ortho G G G G G G G G Lnx1 Il3ra ortho G Lnx1 Kxd1 ortho Lnx1 Suv39h2 ortho G Lsm2 Lnx1 ortho G G G G G G G G G G G G G G G G G Lnx1 Eif4h ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Htr2b ortho G Lnx1 Kctd13 ortho Lnx1 Ulk2 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Src ortho G G G G G G G G G G G G G G G G G G Lnx1 Pbk ortho G G G G G G G G G G G G Lnx1 Rufy4 ortho Lnx1 Camk2n2 ortho Lnx1 Bpifa1 ortho G G Lnx1 Iscu ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Hsbp1 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Ldoc1 ortho Lnx1 Wnt8a ortho Lnx1 Krt15 ortho G G G G Lnx1 Deptor ortho G G G G G G G G G G G G G G G G G G G Lnx1 Nup37 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Ehmt2 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Srsf1 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Cib3 ortho Lnx1 Zfp64 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Kcna4 ortho G G G G G Lnx1 Trmt12 ortho Lnx1 Hunk ortho G G G G G G G G G G G G G G G G G G Lnx1 Nagk ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Ctbp1 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Robo3 ortho Lnx1 Cgn ortho Lnx1 Ormdl3 ortho Lnx1 Trip13 ortho G G G G G G G Lnx1 Aimp2 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Ephb3 ortho G G G G G G G G Lnx1 Gas2l2 ortho Lnx1 Tmem14c ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Dctd ortho Lnx1 Rpia ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Cited1 ortho G G G G G Lnx1 Sdk1 ortho Lnx1 Slc6a5 ortho G Lnx1 Tifa ortho G G G G G G G G G G G G G G G Lnx1 Enox1 ortho Lnx1 Nkd2 ortho Strn Lnx1 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Thap7 ortho G G G G G G G G G G G G G G G G G G G G Protein Fam124a Lnx1 ortho Arhgap6 Lnx1 ortho G G G G G G G G G G G G G G G G G G Ctnnd2 Lnx1 ortho G G G G G G G G Lnx1 Ptgir ortho G G Lnx1 Pkm ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Snrpf ortho Lnx1 Paics ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Dab1 ortho G G G G G G G Protein Magea4 Lnx1 ortho Lnx1 Inpp5k ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Cep72 ortho Lnx1 Hsp90aa1 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Agtrap ortho G G G G G G G G G G G G Lnx1 Stac2 ortho G G G G G G G G G G G Lnx1 Acy3 ortho G G G G G G G G G Lnx1 Jak3 ortho G G G G G G Lnx1 Cldn17 ortho Lnx1 Lclat1 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Aurkc ortho G Lnx1 Cldn2 ortho G G G G G G G G G G Lnx1 Dpf2 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Mvb12b ortho G G G G G G G G G G G G G G G G G G Lnx1 Gjd4 ortho Lnx1 Rad54b ortho Lnx1 Traf2 ortho G G G G G G G G G G G G G G G Lnx1 Nadk ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Trim54 ortho G G G G Suv39h1 Lnx1 ortho G G G G G G G G G G G G G G G G G G Lnx1 Vcp ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Pqbp1 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Plekhg5 ortho G G G G G G G G G G G G G G G G Lnx1 Sh2d2a ortho Clk2 Lnx1 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Zadh2 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Nme7 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 MCG61680, Melanoma antigen family B, 18, Protein Mageb18 ortho Lnx1 Cda ortho G G G G G G G G G G G G G G Lnx1 Ctso ortho Lnx1 Fam212b ortho Lnx1 Atrip ortho Lnx1 Grb2 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Fbp1 ortho G G G G G G G G G G G G Lnx1 Kctd1 ortho G G G G G G G G G G G G G G Lnx1 Apip ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Ropn1 ortho G Lnx1 Abcb1a ortho G G G G G G G G G G G G G G G G Lnx1 Prph ortho G G G G G Rad51d Lnx1 ortho G G G G G G G G G G G G G G G G Lnx1 Lgr6 ortho G G G G G G Lnx1 Blvra ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Ccdc85b ortho Lnx1 Cutc ortho G G G G G G G G G G G G G G G G G G G Lnx1 Kiaa1598 ortho Lnx1 Ccdc114 ortho G Lnx1 Ube2z ortho G G G G G G G G G G G G G G G G G G G G Sclt1 Lnx1 ortho G G G G Lnx1 Pomgnt1 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Ube2d2 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Aldoc ortho G G G G G G G G G G G G G G G G G G G Lnx1 Prkca ortho G G G G G G G G G G G G G G G Lnx1 Dvl3 ortho Lnx1 Dapk1 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 C1qtnf1 ortho G G G G G G Lnx1 Kctd6 ortho Lnx1 Pbld1 ortho G G G G G G Lnx1 Fam118a ortho G G G G G G G G G G G G G G G G G G G Lnx1 Golph3l ortho G G G G G G G G G G G G G G G G G G G Lnx1 Trim23 ortho G G G G G G G G G G G G G G G G G G G Lnx1 Rbmx ortho G G G G G G G G G G G G G G G G G G G G Nck2 Lnx1 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 App ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Tyk2 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Khdrbs3 ortho G G G G G G G G G G G G G G G G G Lnx1 Memo1 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Zbtb43 ortho Lnx1 Ebf4 ortho Lnx1 Ddx17 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Stx5 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Ptpn11 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Nrcam ortho G G G G G G G G G G G Lnx1 Abr ortho G G G G G G G G G G G G G G G G G G G Lnx1 Ccdc101 ortho G G G G G G G G G G G G G G G G G G G Lnx1 Bcr ortho G G G G G G G G G G G G G G G G G G G Lnx1 Pafah1b3 ortho G G G G G G G G G G G G G G G G G G G Protein Kctd17 Lnx1 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Snw1 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Mtmr9 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Tssk3 ortho Lnx1 Rabac1 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Pkp4 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Fbxl12 ortho G G G G G G G G G G G G G G G G G G G Lnx1 Pak6 ortho Lnx1 Arhgef16 ortho G G G G G G G G G G G Lnx1 Hmbox1 ortho G G G G G G G G G G G G G G G G G G G Lnx1 Homez ortho Lnx1 Nudt14 ortho G G G G G G G G G G G G G G G G G G G Lnx1 Socs6 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Wwp1 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Abca1 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Sphkap ortho Lnx1 Pts ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Cirbp ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Ilf3 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Hsp90ab1 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Exoc8 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Dcun1d5 ortho G G G G G G G G G G G G G G G G G G G G Catsperd Lnx1 ortho Lnx1 Ras-like protein family member 11B ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Mrps24 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Vrk2 ortho G G G G G G G G G G G Lnx1 Atpaf2 ortho G G G G G G G G G G G G G G G G G G G G Protein Pdzrn4 Lnx1 ortho Lnx1 Znf593 ortho Lnx1 Rhoc ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Cd8a ortho G G Kalrn Lnx1 ortho G G G G Lnx1 Wac ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Klhl12 ortho Lnx1 Ppia ortho Tnfrsf18 Lnx1 ortho G Lnx1 Ruvbl2 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Ppid ortho Lnx1 Mustn1 ortho G G G G G G G G G G G Lnx1 Sapcd1 ortho G Lnx1 Cpne2 ortho G G G G G G G G G G G G Lnx1 Pcbd1 ortho G G G G G G G G G G G G G G G G G G G Lnx1 Tsc22d4 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Alkbh3 ortho Lnx1 Adra1d ortho Lnx1 Pkdrej ortho Lnx1 Ammecr1l ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Dock9 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Nek6 ortho G G G G G G G G G G G G G G G G G G G Lnx1 Lrrc3b ortho G G G G G G G G G G G Lnx1 Tsc2 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Necab2 ortho G G G G G G G G G G G G Lnx1 Coil ortho G G G G G G G G G G G G G G G G G G G G Lnx1 1700012B18Rik ortho G G G G G G G G G G G G G Lnx1 Ca8 ortho G G G G G G G G G G G G G G G G Lnx1 Fhl3 ortho Lnx1 Osbp2 ortho Lnx1 Snrnp25 ortho G G G G G G G G G G G G G G G G G G G G Lnx1 Sstr3 ortho G Lnx1 Insc ortho Lnx1 Mapk9 ortho G G G G G G G G G G G G G G G G G G G Lnx1 Zbtb8a ortho G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9QZS3 O70263 - 14990566 - X 2 O70263 - 11922143 - X 2 Q9QZS3-2 O70263 - 10551880,11782429,11818085,9535908 - X 2 Q9QZS3-2 O70263 - 14990566 - X 2 O70263 pull down 16832352 association C 3 Q7TSN7 O70263 coimmunoprecipitation 16832352 association X 2 P97792 O70263 two hybrid 12468544 physical association X 2 P97792 O70263 two hybrid 12468544 physical association X 2 P97792 O70263 pull down 12468544 physical association X 2 P97792 O70263 imaging technique 12468544 colocalization X 2 P12931 O70263 anti bait coimmunoprecipitation 17936276 physical association X 2 B1AYL1 O70263 protein array 23022437 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Lnx1 Ca1 MI:0018(two hybrid)|MI:0018(two hybrid) 12468544 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_328958|BIOGRID_328957 prey|prey bait|bait Lnx1 Scn7a MI:0089(protein array)|MI:0089(protein array)|MI:0089(protein array) 23022437 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(intact)|(intact) UniProt_126004|UniProt_175500|UniProt_185785 bait|bait|bait prey|prey|prey Lnx1 Cldn1 MI:0004(affinity chromatography technology) 19295125 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_316093 bait prey Lnx1 Erbb2 MI:0004(affinity chromatography technology) 16122940 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_319859 bait prey Lnx1 Numb MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 9535908 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_322467|BIOGRID_322466 prey|prey bait|bait Lnx1 Igsf5 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 16832352 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_333049|BIOGRID_333047|BIOGRID_333046 prey|prey|prey bait|bait|bait Lnx1 Cxadr MI:0096(pull down)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down) 12468544 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization) MI:0471(mint)|(intact)|MI:0471(mint)|(intact)|MI:0471(mint)|(intact)|(intact)|MI:0471(mint) MINT_59880|UniProt_163435|MINT_59878|UniProt_163436|MINT_59879|UniProt_163434|UniProt_163433|MINT_59881 prey|prey|prey|unspecified role|prey|prey|prey|unspecified role bait|bait|bait|unspecified role|bait|bait|bait|unspecified role

PPI - HINT Gene A Gene B PMID Method Quality LNX1 CA1 12468544,12468544 0004,0018 LC LNX1 CXADR 12468544,12468544,12468544 0428,0018,0096 LC LNX1 SCN7A 23022437 0089 LC LNX1 IGSF5 16832352,16832352,PDB_3VQG,16832352,16832352 0019,0004,0114,0096,0428 LC LNX1 LNX2 11922143 0018 LC LNX1 NUMB 14990566,14990566,10551880,10551880,9535908,9535908,10551880,9535908,11782429,14990566,14990566 0053,0004,0019,0004,0047,0004,0045,0045,0019,0405,0045 LC LNX1 LNX1 9535908 0004 LC LNX1 CLDN1 19295125 0004 LC LNX1 CA1 12468544,12468544 0004,0018 LC LNX1 ERBB2 16122940 0004 LC LNX1 CXADR 12468544,12468544,12468544 0428,0018,0096 LC LNX1 IGSF5 16832352,16832352,16832352,16832352 0019,0004,0096,0428 LC LNX1 NUMB 14990566,14990566,10551880,10551880,9535908,9535908,10551880,9535908,14990566,14990566 0053,0004,0019,0004,0047,0004,0045,0045,0405,0045 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID O70263 B1AYL1 LNX1 SCN7A 0.309 23022437 O70263 O70263 LNX1 LNX1 0.236 9535908 O88551 O70263 CLDN1 LNX1 0.21 19295125 P12931 O70263 SRC LNX1 0.21 17936276 P49757 O70263 NUMB LNX1 0.21 9535908 P70424 O70263 ERBB2 LNX1 0.21 16122940 Q9QZS3 O70263 NUMB LNX1 0.454 9535908 P13634 O70263 CA1 LNX1 0.454 12468544 Q7TSN7 O70263 IGSF5 LNX1 0.523 16832352 P97792 O70263 CXADR LNX1 0.523 12468544