PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Foxp3 Anapc7 22922362 biogrid exp Ywhah Anapc7 21311561 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Crem Anapc7 16595651 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Pik3ca Anapc7 15102471 mint,intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Creb3l4 Anapc7 16595651 biogrid exp G G G G G G G G Cdc20 Anapc7 22084091 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G Cdc27 Anapc7 10922056 biogrid exp, ortho G G G G G G Protein Taf4a Anapc7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc4 Anapc7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sirt6 Anapc7 ortho Anapc1 Anapc7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ncl Anapc7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Phf8 Anapc7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc5 Anapc7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pten Anapc7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc16 Anapc7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cfap97 Anapc7 ortho G G G Xpo1 Anapc7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdc1 Anapc7 ortho P Foxq1 Anapc7 ortho G G G G G G G G G G G G Usp37 Anapc7 ortho Magix Anapc7 ortho G G G G Ubc Anapc7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc5l Anapc7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vcp Anapc7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E2f1 Anapc7 ortho G G G G G Ep300 Anapc7 ortho P Foxs1 Anapc7 ortho Crebbp Anapc7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkcsh Anapc7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nek2 Anapc7 ortho G G G G G G G G Anapc16 Anapc7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc23 Anapc7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cacng4 Anapc7 ortho G G G G G Anapc7 Anapc7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdh1 Anapc7 ortho G G G G G G G G G G G G G G G G G G G G G G Smarcad1 Anapc7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Notch1 Anapc7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tenm2 Anapc7 ortho P G G G G G G Cdc26 Anapc7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Plekho2 Anapc7 ortho GP G G G G G G G G G G G G G G G G G G G G G G Sox2 Anapc7 ortho G G G G G G G G G G G Ddhd2 Anapc7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc10 Anapc7 ortho Anapc7 Bub1b ortho G G G G G G G G G G G G D6Wsu163e Anapc7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdt1 Anapc7 ortho G G G G G G G G G G G G G G G G G G G G G G G G Tp53bp1 Anapc7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cops5 Anapc7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxo5 Anapc7 ortho Fzr1 Anapc7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc2 Anapc7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc13 Anapc7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Grap2 Anapc7 ortho Ccdc8 Anapc7 ortho Trim33 Anapc7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspb1 Anapc7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sh3kbp1 Anapc7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Nap1l4 Anapc7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bap1 Anapc7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Supt6h Anapc7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9D2A5 Q9WVM3 affinity chromatography technology 16595651 physical association X 2 P42336 Q9WVM3 two hybrid 20368287 direct interaction X 2 Q53Z59 Q9WVM3 affinity chromatography technology 22922362 physical association X 2 Q9WVM3 A2A6Q5 affinity chromatography technology 10922056 physical association X 2 Q9WVM3 D3Z7M6 affinity chromatography technology 16595651 physical association X 2 Q9JJ66 Q9WVM3 affinity chromatography technology 22084091 physical association X 2 Q9WVM3 coimmunoprecipitation 10318877 association C 9 P42337 Q9WVM3 two hybrid 15102471 physical association X 2 P42337 Q9WVM3 two hybrid 15102471 physical association X 2 P42336 Q9WVM3 two hybrid 20368287 physical association X 2

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9WVM3 Q9JJ66 ANAPC7 CDC20 0.21 22084091 Q9WVM3 P42337 ANAPC7 PIK3CA 0.183 15102471 Q9WVM3 P42336 ANAPC7 PIK3CA 0.332 20368287 Q9WVM3 Q99JB6 ANAPC7 FOXP3 0.126 22922362 Q9WVM3 Q9D2A5 ANAPC7 CREB3L4 0.21 16595651 Q9WVM3 P27699 ANAPC7 CREM 0.21 16595651 Q9WVM3 P68510 ANAPC7 YWHAH 0.126 21311561 Q9WVM3 A2A6Q5 ANAPC7 CDC27 0.21 10922056