PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Isg15 Usp18 24533902 biogrid,intact exp, ortho Ppp5c Usp18 ortho G G G G G G G G G G G G G G G G G G G G G G G Usp18 Skp2 ortho G G G G G G G G G G Nxf1 Usp18 ortho G G G G G G G G G G G G G G G G G G G G G G G Ikbkg Usp18 ortho G G G G G G G G G G G G G G G G G G G G G G G Fkbpl Usp18 ortho G G G G G G G G G G G G G G G G Mov10 Usp18 ortho G G G G G G G G G G G G G G G G G G Pcna Usp18 ortho G G G G G G G G G G G G G G G G G G G G G G G Zdhhc17 Usp18 ortho Ttc1 Usp18 ortho G G G G G G G G G G G G G G G G G G G G G G G Atg14 Usp18 ortho G G G G G G G G G G G G G G G G G G G G G G G Tmem14a Usp18 ortho Mlf1 Usp18 ortho G G G G G G G G G G Nme1 Usp18 ortho G G G G G G G G G G G G G G G G G G G G G G G Aarsd1 Usp18 ortho G G G G G G G G G G G G G G G G G G G G G G G Trim54 Usp18 ortho G G G G G G Hsp90ab1 Usp18 ortho G G G G G G G G G G G G G G G G G G G G G G G Kdm3b Usp18 ortho G G G G G G G G G G G G G G G G G G G G G G G Nudcd3 Usp18 ortho G G G G G G G G G G G G G G G G G G G G G G G Fkbp5 Usp18 ortho G G G G G G G G G G G G G G G G G G G G G G G Sugt1 Usp18 ortho G G G G G G G G G G G G G G G G G G G G G G G Pik3c3 Usp18 ortho G G G G G G G G G G G G G G G G G G G G G G G Stip1 Usp18 ortho G G G G G G G G G G G G G G G G G G G G G G G Protein Herc1 Usp18 ortho G G G G G G G G G G G G G G G G G G G G G G G Hspa8 Usp18 ortho G G G G G G G G G G G G G G G G G G G G G G G Myl6 Usp18 ortho G G G G G G G G G G G G G G G G G G G G G G G Ifnar2 Usp18 ortho G G G G G G G G G G G G G G G G G G G G G G G Sgta Usp18 ortho G G G G G G G G G G G G G G G G G G G G G G G Cacybp Usp18 ortho G G G G G G G G G G G G G G G G G G G G G G G Becn1 Usp18 ortho G G G G G G G G G G G G G G G G G G G G G G G Protein Uvrag Usp18 ortho G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9WTV6 Q64339 pull down 24533902 direct interaction X 2 Q9WTV6 Q64339 microscale thermophoresis 24533902 direct interaction X 2 Q9WTV6 Q64339 enzymatic study 24533902 cleavage reaction X 2

PPI - HINT Gene A Gene B PMID Method Quality ISG15 USP18 24533902,PDB_5CHV,24533902,24533902 0415,0114,1247,0096 LC USP18 USP18 PDB_5CHT,PDB_5CHV 0114,0114 LC IRF8 USP18 21731497 0007 LC ISG15 USP18 24533902,24533902,24533902 0415,1247,0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9WTV6 Q64339 USP18 ISG15 0.539 24533902