PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Usp9x Eed 24457600 innatedb,biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Sall4 20362541 biogrid,intact exp Ywhae Usp9x 16615898 intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Htt Usp9x 17500595 biogrid,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dcx Usp9x 15607950 biogrid exp, ortho G G G G G Usp9x Ctnnb1 15607950 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Unk 25737280 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Lats2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Ecm29 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Yap1 Usp9x ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pex5 Usp9x ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Axin1 Usp9x ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Casp4 Usp9x ortho G G G G G G G G G G G G G Usp9x Tenm2 ortho P G G G G G G Usp9x Srxn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Csnk1e ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Ntrk1 ortho Usp9x Ikbkap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x March7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Nudcd2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Epn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdh1 Usp9x ortho G G G G G G G G G G G G G G G G G G G G G G Protein Sec24c, SEC24 related gene family, member C (S. cerevisiae), isoform CRA_a Usp9x ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sssca1 Usp9x ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Clk3 Usp9x ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Gpsm1 ortho P G G G G G G G G G G G G G G Usp9x Psd4 ortho Usp9x Rassf10 ortho Usp9x Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Usp9x ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Smad3 ortho G G G G G G G G G G G G G G G Usp9x Bcar3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Hdac6 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Apc ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Peg10 ortho G Usp9x Dvl3 ortho Usp9x Ubqln2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Nek6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmb8 Usp9x ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Sox2 Usp9x ortho G G G G G G G G G G G Tsc22d1 Usp9x ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Cct4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Ube2c ortho G G G G G G G G G G G G G G G G G G Usp9x Asb15 ortho G G G G Eftud2 Usp9x ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Uchl3 ortho P Usp9x Ppp5c ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Mib1 ortho P G G G G G G G G G Ccdc8 Usp9x ortho Usp9x Nubp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Rictor ortho P Usp9x Grk5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Psma4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Mex3c ortho Smad1 Usp9x ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Erg ortho Sod1 Usp9x ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Hdac5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2b Usp9x ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Igbp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G Usp9x Ufc1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Psmb4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Relb ortho G G G G G G G G G G G G Usp9x Bcl10 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ntn1 Usp9x ortho G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d2 Usp9x ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Zfyve19 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Phb Usp9x ortho P Usp9x Ubl7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Mark4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Terf1 Usp9x ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc3 Usp9x ortho G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Mtor ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Shb ortho P Tcp1 Usp9x ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k1 Usp9x ortho G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Zyx ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc5 Usp9x ortho G G G G G G G G G G G G G G Usp9x Aurka ortho G G G G G G G G G G G G G G Usp9x Cand1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubr4 Usp9x ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Rps6kb2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Shc1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Ube2v2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ruvbl1 Usp9x ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Smad4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Maged1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Prpf8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Ect2 ortho G G G G G G G G G G G G G Usp9x Hecw2 ortho Usp9x Ttll12 ortho P Usp9x Dcaf6 ortho Usp9x Mllt4 ortho P Sash1 Usp9x ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Itch ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Arl6ip5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Usp34 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2l3 Usp9x ortho P Usp9x Prickle1 ortho G G G G G G G G G G G G G G G G G G G G G G G Usp9x Prickle2 ortho Usp9x Huwe1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cftr Usp9x ortho G G G G G G G G Usp9x Nfkb2 ortho P G G G G G G G G G G G G G Jun Usp9x ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pja1 Usp9x ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Egfr ortho GP G G G G G G G G G G G G G G G G G Usp9x Xpo1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Cul3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Ubxn7 ortho P Usp9x Rptor ortho P Usp9x Dvl2 ortho G G G G G G G G G G G G Terf2 Usp9x ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Ubqln1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Pkp3 ortho G G G G G G G G G G G G G G G G G G G G Ufm1 Usp9x ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Smurf1 ortho Nfx1 Usp9x ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Usp9x ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d1 Usp9x ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Nuak1 ortho Myc Usp9x ortho G G G G G G G G G G G G G G G G G G G G G Usp9x Ahcyl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Mcl1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Malt1 ortho Usp9x Smad2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Sec23a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Atp6v1f ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Snrnp200 ortho P Usp9x Sirt7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Snca Usp9x ortho P G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q5YB86 P70398 mass spectrometry studies of complexes 17038327 association X 2 Q5YB86 P70398 affinity chromatography technology 17038327 association X 2 Q5YB86 P70398 coimmunoprecipitation 17038327 association X 2 P70398 anti bait coimmunoprecipitation 17500595 association C 9 A5PKW4 P70398 pull down 20339350 direct interaction X 2 A5PKW4 P70398 pull down 20339350 physical association X 2 A5PKW4 P70398 fluorescence microscopy 20339350 colocalization X 2 Q95LE0 P70398 fluorescence microscopy 20339350 colocalization X 2 P70398 anti tag coimmunoprecipitation 22653443 association C 31 P70398 anti tag coimmunoprecipitation 20362541 association C 42 A0A024R5Z3 P70398 anti tag coimmunoprecipitation 19135894 physical association X 2 P70398 A0A024R274 anti tag coimmunoprecipitation 19135894 physical association X 2 P70398 A0A024R274 anti bait coimmunoprecipitation 19135894 physical association X 2 P70398 A0A024R274 anti bait coimmunoprecipitation 19135894 physical association X 2 P70398 A0A024R274 enzymatic study 19135894 deubiquitination reaction X 2 Q15796 P70398 anti tag coimmunoprecipitation 19135894 physical association X 2 Q15796 P70398 anti tag coimmunoprecipitation 19135894 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Usp9x Ctnnb1 MI:0018(two hybrid) 15607950 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_319538 bait prey Usp9x Sall4 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 20362541 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0914(association)|MI:0915(physical association) (intact)|(intact)|(biogrid) UniProt_107198|UniProt_170697|BIOGRID_313997 prey|prey|prey bait|bait|bait Htt Usp9x MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 17500595 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_166535|BIOGRID_323650 bait|bait prey|prey Usp9x Usp9x MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 10,20339350 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization) (intact)|MI:0471(mint)|(intact) UniProt_170979|MINT_76670|UniProt_105809 neutral component|neutral component|neutral component neutral component|neutral component|neutral component Usp9x Eed MI:0004(affinity chromatography technology) 24457600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_332736 prey bait Dcx Usp9x MI:0018(two hybrid) 15607950 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_319536 bait prey Usp9x PSD MI:0096(pull down)|MI:0096(pull down) 10 taxid:10090(Mus musculus) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) MI:0471(mint)|MI:0471(mint) MINT_76662|MINT_46026 bait|bait prey|prey

PPI - HINT Gene A Gene B PMID Method Quality YWHAE USP9X 16615898 0027 LC UBC USP9X 26811477 0004 LC USP9X CTNNB1 15607950 0004 LC USP9X DCX 15607950 0004 LC USP9X SALL4 20362541,20362541 0004,0007 LC USP9X EED 24457600 0004 LC USP9X CHAF1A 26365490 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P70398 P62259 USP9X YWHAE 0.081 16615898 P70398 P0CG50 USP9X UBC 0.21 26811477 P70398 O88809 USP9X DCX 0.21 15607950 Q8BL48 P70398 UNK USP9X 0.126 25737280 P70398 P04637 USP9X TP53 0.126 22653443 Q13485 P70398 SMAD4 USP9X 0.539 19135894 Q8BX22 P70398 SALL4 USP9X 0.236 20362541 Q95LE0 P70398 Q95LE0 USP9X 0.126 20339350 Q921E6 P70398 EED USP9X 0.126 24457600 Q9QWF0 P70398 CHAF1A USP9X 0.126 26365490 P70398 A5PKW4 USP9X PSD 0.523 20339350 P84022 P70398 SMAD3 USP9X 0.376 19135894 Q02248 P70398 CTNNB1 USP9X 0.21 15607950 Q15796 P70398 SMAD2 USP9X 0.376 19135894 P70398 P42859 USP9X HTT 0.126 17500595