PTM - CPLM Gene Name UniProt ID Type Position Code Cttn; Ems1 Q60598 Acetylation 87 K Cttn; Ems1 Q60598 Acetylation 124 K Cttn; Ems1 Q60598 Acetylation 144 K Cttn; Ems1 Q60598 Acetylation 161 K Cttn; Ems1 Q60598 Acetylation 189 K Cttn; Ems1 Q60598 Acetylation 198 K Cttn; Ems1 Q60598 Acetylation 203 K Cttn; Ems1 Q60598 Acetylation 235 K Cttn; Ems1 Q60598 Acetylation 272 K Cttn; Ems1 Q60598 Acetylation 304 K Cttn; Ems1 Q60598 Acetylation 309 K Cttn; Ems1 Q60598 Acetylation 319 K Cttn; Ems1 Q60598 Acetylation 107 K Cttn; Ems1 Q60598 Acetylation 110 K Cttn; Ems1 Q60598 Acetylation 263 K Cttn; Ems1 Q60598 Acetylation 181 K Cttn; Ems1 Q60598 Acetylation 205 K Cttn; Ems1 Q60598 Acetylation 295 K Cttn; Ems1 Q60598 Acetylation 346 K Cttn; Ems1 Q60598 Acetylation 171 K Cttn; Ems1 Q60598 Succinylation 171 K Cttn; Ems1 Q60598 Ubiquitination 124 K Cttn; Ems1 Q60598 Ubiquitination 309 K Cttn; Ems1 Q60598 Ubiquitination 336 K

PTM - dbPAF Gene Name UniProt ID Position Type Species Cttn; Ems1 Q60598 104 Y Mus musculus(Mouse) Cttn; Ems1 Q60598 109 S Mus musculus(Mouse) Cttn; Ems1 Q60598 11 S Mus musculus(Mouse) Cttn; Ems1 Q60598 113 S Mus musculus(Mouse) Cttn; Ems1 Q60598 13 T Mus musculus(Mouse) Cttn; Ems1 Q60598 141 Y Mus musculus(Mouse) Cttn; Ems1 Q60598 150 S Mus musculus(Mouse) Cttn; Ems1 Q60598 154 Y Mus musculus(Mouse) Cttn; Ems1 Q60598 172 S Mus musculus(Mouse) Cttn; Ems1 Q60598 215 Y Mus musculus(Mouse) Cttn; Ems1 Q60598 24 T Mus musculus(Mouse) Cttn; Ems1 Q60598 282 S Mus musculus(Mouse) Cttn; Ems1 Q60598 289 Y Mus musculus(Mouse) Cttn; Ems1 Q60598 298 S Mus musculus(Mouse) Cttn; Ems1 Q60598 302 Y Mus musculus(Mouse) Cttn; Ems1 Q60598 322 S Mus musculus(Mouse) Cttn; Ems1 Q60598 334 Y Mus musculus(Mouse) Cttn; Ems1 Q60598 401 T Mus musculus(Mouse) Cttn; Ems1 Q60598 405 S Mus musculus(Mouse) Cttn; Ems1 Q60598 407 S Mus musculus(Mouse) Cttn; Ems1 Q60598 417 S Mus musculus(Mouse) Cttn; Ems1 Q60598 418 S Mus musculus(Mouse) Cttn; Ems1 Q60598 421 Y Mus musculus(Mouse) Cttn; Ems1 Q60598 433 Y Mus musculus(Mouse) Cttn; Ems1 Q60598 442 Y Mus musculus(Mouse) Cttn; Ems1 Q60598 460 Y Mus musculus(Mouse) Cttn; Ems1 Q60598 466 Y Mus musculus(Mouse) Cttn; Ems1 Q60598 47 S Mus musculus(Mouse) Cttn; Ems1 Q60598 475 Y Mus musculus(Mouse) Cttn; Ems1 Q60598 482 Y Mus musculus(Mouse) Cttn; Ems1 Q60598 5 S Mus musculus(Mouse)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q60598 K87-ac Acetylation ASHGYGGkFGVEQDR Q60598 K124-ac Acetylation sVrGFGGkFGVQMDR Q60598 K161-ac Acetylation ysSGFGGkYGVQADR Q60598 K181-ac Acetylation VGFDYQGkTEKHESQ Q60598 K235-ac Acetylation YVKGFGGkFGVQTDR Q60598 K309-ac Acetylation yAKGFGGkYGVQKDR Q60598 R119-m1 Methylation CsQVDsVrGFGGkFG Q60598 S5-p Phosphorylation ___MWKAsAGHAVsI Q60598 S11-p Phosphorylation AsAGHAVsItQDDGG Q60598 T13-p Phosphorylation AGHAVsItQDDGGAD Q60598 T24-p Phosphorylation GGADDWEtDPDFVND Q60598 S47-p Phosphorylation GAKTVQGsGHQEHIN Q60598 Y104-p Phosphorylation RSAVGHEyQSKLSKH Q60598 S113-p Phosphorylation SKLSKHCsQVDsVrG Q60598 S117-p Phosphorylation KHCsQVDsVrGFGGk Q60598 Y141-p Phosphorylation QSAVGFEyQGKTEKH Q60598 S150-p Phosphorylation GKTEKHAsQKDysSG Q60598 Y154-p Phosphorylation KHAsQKDysSGFGGk Q60598 S155-p Phosphorylation HAsQKDysSGFGGkY Q60598 S172-p Phosphorylation QADRVDKsAVGFDYQ Q60598 Y215-p Phosphorylation KSAVGFEyQGKTEKH Q60598 S224-p Phosphorylation GKTEKHEsQKDYVKG Q60598 S261-p Phosphorylation EKLQLHEsQKDYKTG Q60598 S282-p Phosphorylation VQSERQDsSAVGFDy Q60598 Y289-p Phosphorylation sSAVGFDyKERLAKH Q60598 S298-p Phosphorylation ERLAKHEsQQDyAKG Q60598 Y302-p Phosphorylation KHEsQQDyAKGFGGk Q60598 Y334-p Phosphorylation VVQVPSAyQkTVPIE Q60598 T401-p Phosphorylation QARAKKQtPPAsPsP Q60598 S405-p Phosphorylation KKQtPPAsPsPQPIE Q60598 S407-p Phosphorylation QtPPAsPsPQPIEDR Q60598 S417-p Phosphorylation PIEDRPPssPIyEDA Q60598 S418-p Phosphorylation IEDRPPssPIyEDAA Q60598 Y421-p Phosphorylation RPPssPIyEDAAPFK Q60598 Y433-p Phosphorylation PFKAEPSyRGSEPEP Q60598 Y442-p Phosphorylation GSEPEPEySIEAAGI Q60598 Y460-p Phosphorylation GSQQGLTyTSEPVyE Q60598 Y466-p Phosphorylation TyTSEPVyETTEAPG Q60598 Y475-p Phosphorylation TTEAPGHyQAEDDTy Q60598 Y482-p Phosphorylation yQAEDDTyDGYESDL Q60598 Y497-p Phosphorylation GITAIALyDyQAAGD Q60598 Y499-p Phosphorylation TAIALyDyQAAGDDE Q60598 Y541-p Phosphorylation YGLFPANyVELRQ__ Q60598 K124-ub Ubiquitination sVrGFGGkFGVQMDR Q60598 K309-ub Ubiquitination yAKGFGGkYGVQKDR Q60598 K336-ub Ubiquitination QVPSAyQkTVPIEAV

PTM - dbPTM UniProt ID Position Code Type Resources References Q60598 401 T Phosphorylation Swiss-Prot 1010711 17242355;19367708 Q60598 405 S Phosphorylation Swiss-Prot 1010711 17242355 Q60598 407 S Phosphorylation Swiss-Prot 1010711 17242355 Q60598 418 S Phosphorylation Swiss-Prot 1010711 17114649 Q60598 405 S Phosphorylation PhosphoELM.10011 17242355 Q60598 407 S Phosphorylation PhosphoELM.10011 17242355 Q60598 418 S Phosphorylation PhosphoELM.10011 17114649 Q60598 113 S Phosphorylation PhosphoELM.10011 16854367 Q60598 150 S Phosphorylation PhosphoELM.10011 16854367 Q60598 282 S Phosphorylation PhosphoELM.10011 16854367 Q60598 401 T Phosphorylation PhosphoELM.10011 17242355 Q60598 215 Y Phosphorylation PhosphoELM.10011 15592455 Q60598 421 Y Phosphorylation PhosphoELM.10011 15592455;15169891;10921917 Q60598 466 Y Phosphorylation PhosphoELM.10011 15169891;10921917 Q60598 482 Y Phosphorylation PhosphoELM.10011 10921917;10921917 Q60598 405 S Phosphorylation SysPTM 1.1 17242355 Q60598 407 S Phosphorylation SysPTM 1.1 17242355 Q60598 417 S Phosphorylation SysPTM 1.1 17242355 Q60598 418 S Phosphorylation SysPTM 1.1 17242355;18515860 Q60598 401 T Phosphorylation SysPTM 1.1 17242355 Q60598 334 Y Phosphorylation SysPTM 1.1 18515860 Q60598 421 Y Phosphorylation SysPTM 1.1 18515860;17242355 Q60598 442 Y Phosphorylation SysPTM 1.1 18563927 Q60598 466 Y Phosphorylation SysPTM 1.1 18563927

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q60598 401 T 17242355 HTP Phosphorylation Q60598 482 Y 10921917 SRC LTP Phosphorylation Q60598 482 Y 10921917 Fer LTP Phosphorylation Q60598 150 S 16854367 PAK3 LTP Phosphorylation Q60598 421 Y 15592455 HTP Phosphorylation Q60598 421 Y 15169891 SRC LTP Phosphorylation Q60598 421 Y 10921917 Fer LTP Phosphorylation Q60598 113 S 16854367 PAK3 LTP Phosphorylation Q60598 407 S 17242355 HTP Phosphorylation Q60598 215 Y 15592455 HTP Phosphorylation Q60598 418 S 17114649 HTP Phosphorylation Q60598 282 S 16854367 PAK3 LTP Phosphorylation Q60598 466 Y 15169891 SRC LTP Phosphorylation Q60598 466 Y 10921917 Fer LTP Phosphorylation Q60598 405 S 17242355 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q60598 87 N6-acetyllysine 23806337 Q60598 113 Phosphoserine 21183079 Q60598 119 Omega-N-methylarginine 24129315 Q60598 124 N6-acetyllysine 23806337 Q60598 144 N6-acetyllysine; alternate 23806337 Q60598 161 N6-acetyllysine 23806337 Q60598 181 N6-acetyllysine; alternate 23806337 Q60598 198 N6-acetyllysine 23806337 Q60598 235 N6-acetyllysine 23806337 Q60598 272 N6-acetyllysine 23806337 Q60598 295 N6-acetyllysine; alternate 23806337 Q60598 309 N6-acetyllysine 23806337 Q60598 346 N6-acetyllysine 23806337 Q60598 401 Phosphothreonine 17242355;21183079 Q60598 405 Phosphoserine 17242355;21183079 Q60598 407 Phosphoserine 17242355;21183079 Q60598 418 Phosphoserine 21183079 Q60598 482 Phosphotyrosine; by SRC 22252131 Q60598 485 Phosphotyrosine; by SRC 22252131

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type Cttn IPI00118143 S 113 KLSKHCpSQVDSVR phosphorylation Cttn IPI00118143 S 405 KQTPPApSPSPQPI phosphorylation Cttn IPI00118143 S 407 TPPASPpSPQPIED phosphorylation Cttn IPI00118143 S 417 IEDRPPpSSPIYED phosphorylation Cttn IPI00118143 T 401 ARAKKQpTPPASPS phosphorylation Cttn IPI00624988 S 11 SAGHAVpSITQDDG phosphorylation Cttn IPI00624988 S 113 KLSKHCpSQVDSVR phosphorylation Cttn IPI00624988 S 298 RLAKHEpSQQDYAK phosphorylation Cttn IPI00624988 S 405 KQTPPApSPSPQPI phosphorylation Cttn IPI00624988 S 407 TPPASPpSPQPIED phosphorylation Cttn IPI00624988 S 417 IEDRPPpSSPIYED phosphorylation Cttn IPI00624988 S 418 EDRPPSpSPIYEDA phosphorylation Cttn IPI00624988 T 401 ARAKKQpTPPASPS phosphorylation

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID Cttn Mus musculus (Mouse) 124; 309; 336 "124,VRGFGGKFGVQMD; 309,AKGFGGKYGVQKD; 336,VPSAYQKTVPIEA" 124:22790023; 309:22790023; 336:22790023