DNA & RNA Element - AREsite Gene Name Motif CDS Area ARE Area Evidence Hdac6 ATTTA 192-3650 3776-3780;3966-3970 Hdac6 WWATTTAWW 192-3650 3964-3972

DNA & RNA Element - miRTarBase Target Gene (Entrez ID) miRTarBase ID miRNA Species (miRNA) Target Gene Species (Target Gene) Experiments Support Type References (PMID) MIRT010806 mmu-miR-324-3p Mus musculus Hdac6 15185 Mus musculus Sequencing Functional MTI (Weak) 19536157 MIRT008885 mmu-miR-362-5p Mus musculus Hdac6 15185 Mus musculus Sequencing Functional MTI (Weak) 19536157 MIRT007479 mmu-miR-758-3p Mus musculus Hdac6 15185 Mus musculus Sequencing Functional MTI (Weak) 19536157

DNA & RNA Element - microRNA Mirbase Acc miRNA Name Gene ID Gene Symbol miRNA Alignment Alignment Gene Alignment miRNA Start miRNA End Gene Start Gene End Genome Coordinates Conservation Align Score Seed Cat Energy mirSVR Score MIMAT0004529 mmu-miR-125b* 15185 Hdac6 uccAGGGUUCUUGGACUG-AACa || ||||:| |||| ||| agaUCACAAGGA--UGACAUUGa 2 20 261 281 [mm9:X:7507314-7507334:-] 0.5026 124 0 -13.46 -0.5375 MIMAT0004622 mmu-let-7c-1* 15185 Hdac6 ccUUUCGAUCUUCCAAC-AUGUc ||||:|:|| |||| |||| auAAAGUUGGA--GUUGCUACAa 2 21 321 341 [mm9:X:7507254-7507274:-] 0.7120 133 0 -14.39 -1.1847 MIMAT0004626 mmu-miR-18a* 15185 Hdac6 guCUUCCUCGUGAAUCCCGUCa ||:| || ||||||| cuGAGGCCACAGGCAGGGCAGc 2 21 29 50 [mm9:X:7507545-7507566:-] 0.5834 148 7 -19.29 -0.2196 MIMAT0004626 mmu-miR-18a* 15185 Hdac6 guCUUCCUCGUGAAUCCC-GUCa ||||||| : |||| ||| caGAAGGAGGG---AGGGACAGc 2 21 218 237 [mm9:X:7507358-7507377:-] 0.6716 120 0 -25.43 -0.5795 MIMAT0004628 mmu-miR-21* 15185 Hdac6 cuGUCGGGUAGCUGAC-GACAAc ||| ||| | |||| ||||| ccCAGACCA-C-ACUGCCUGUUu 2 21 3 23 [mm9:X:7507572-7507592:-] 0.6619 128 0 -17.17 -0.2913 MIMAT0000578 mmu-miR-337-3p 15185 Hdac6 ucCGUAGUAUAUCCUCGACUu || :| : ||||||||| uaGCCCUAGGAAGGAGCUGAg 2 20 242 262 [mm9:X:7507333-7507353:-] 0.5871 155 7 -20.69 -0.3175 MIMAT0004668 mmu-miR-138* 15185 Hdac6 gggaccacaacacuUCAUCGGc ||||||| gggagggacagcuuAGUAGCCc 2 9 226 247 [mm9:X:7507348-7507369:-] 0.6716 140 7 -13.13 -0.6847 MIMAT0000706 mmu-miR-362-5p 15185 Hdac6 uaagugUGGAUCCAAG-GUUCCUAa | ||: | || ||||||| ggaaggAGCUGAGAUCACAAGGAUg 2 19 250 274 [mm9:X:7507321-7507345:-] 0.5871 153 7 -13.90 -0.3988 MIMAT0003409 mmu-miR-467a 15185 Hdac6 gcguauaUGUACGU-CCGU-GAAu ||| ||| |||| ||| ugaggccACAGGCAGGGCAGCUUa 2 16 30 53 [mm9:X:7507542-7507565:-] 0.5834 122 0 -15.08 -0.3084 MIMAT0003170 mmu-miR-541 15185 Hdac6 ucacACUGGUUGUAG-UCUUA-GGGAa ||| | |||| |||| |||| cacuUGAAC-CCAUCUUGAAUACCCUu 2 22 88 113 [mm9:X:7507482-7507507:-] 0.5807 122 0 -17.73 -0.7722 MIMAT0005448 mmu-miR-467b 15185 Hdac6 guauaUGUACGU-CCGU-GAAUg ||| ||| |||| |||| aggccACAGGCAGGGCAGCUUAg 2 17 32 54 [mm9:X:7507541-7507563:-] 0.5834 127 0 -14.43 -0.1993 MIMAT0003502 mmu-miR-712 15185 Hdac6 ccauggcgggcccACUUCCUc ||||||| acaaggaugacauUGAAGGAg 2 9 266 286 [mm9:X:7507309-7507329:-] 0.5574 140 7 -16.09 -0.5205 MIMAT0004841 mmu-miR-871 15185 Hdac6 guACUGACCGUGAUUAG-ACUUAu | ||| | || ||| ||||| ccUCACUUGAACCCAUCUUGAAUa 2 22 85 108 [mm9:X:7507487-7507510:-] 0.5807 129 0 -10.09 -0.5576 MIMAT0007865 mmu-miR-1897-3p 15185 Hdac6 gaguggccugucuugCUCAACu |||||| uauuuaauaaaguugGAGUUGc 2 8 315 336 [mm9:X:7507259-7507280:-] 0.6621 120 6 -9.26 -0.1462 MIMAT0007872 mmu-miR-1906 15185 Hdac6 ucGGGACGGAGUCCGAC-GACGu ||||||| || ||| |||| gcCCCUGCC-CA--CUGCCUGCu 2 21 176 195 [mm9:X:7507400-7507419:-] 0.6490 127 0 -25.11 -0.2729 MIMAT0000235 mmu-miR-202-3p 15185 Hdac6 agAAGGGU-A-CGCGAUAUGGAGa | ||:: | | | ||||||| acUGCCUGCUCGAGGAAUACCUCu 2 21 186 209 [mm9:X:7507386-7507409:-] 0.6490 142 7 -18.49 -0.3753 MIMAT0000381 mmu-miR-34c 15185 Hdac6 cguUAGUCGAUUGAUGUGACGGa ||| | :|| |||||||| ---AUC-CCAGACCACACUGCCu 2 21 1 19 [mm9:X:7507576-7507594:-] 0.6619 158 7 -19.00 -0.7431 MIMAT0000381 mmu-miR-34c 15185 Hdac6 cguuagucgauugauGUGACGGa ||||||| ugaugugccccugccCACUGCCu 2 9 170 192 [mm9:X:7507403-7507425:-] 0.6490 140 7 -15.98 -0.2618 MIMAT0000382 mmu-miR-34b-5p 15185 Hdac6 uguUAGUCGAUUAAUGUGACGGa ||| | :| |||||||| ---AUC-CCAGACCACACUGCCu 2 21 1 19 [mm9:X:7507576-7507594:-] 0.6619 150 7 -18.29 -0.7431 MIMAT0000382 mmu-miR-34b-5p 15185 Hdac6 uguuagucgauuaauGUGACGGa ||||||| ugaugugccccugccCACUGCCu 2 9 170 192 [mm9:X:7507403-7507425:-] 0.6490 140 7 -15.86 -0.2618 MIMAT0000531 mmu-miR-22 15185 Hdac6 ugucaagaaguugaCCGUCGAa ||||||| gaggccacaggcagGGCAGCUu 2 9 31 52 [mm9:X:7507543-7507564:-] 0.5834 140 7 -18.67 -0.2562 MIMAT0000542 mmu-miR-34a 15185 Hdac6 uguuGGUCGAUUCUGUGACGGu |||| | |||||||| -aucCCAG--ACCACACUGCCu 2 19 1 19 [mm9:X:7507576-7507594:-] 0.6619 151 7 -20.28 -0.7394 MIMAT0000542 mmu-miR-34a 15185 Hdac6 uguuggucgauucuGUGACGGu ||||||| gaugugccccugccCACUGCCu 2 9 171 192 [mm9:X:7507403-7507424:-] 0.6490 140 7 -16.39 -0.2595 MIMAT0001076 mmu-miR-384-3p 15185 Hdac6 uaacacuuguuaaaGAUCCUUa ||||||| acagcuuaguagccCUAGGAAg 2 9 233 254 [mm9:X:7507341-7507362:-] 0.6716 140 7 -12.87 -0.2604 MIMAT0001095 mmu-miR-370 15185 Hdac6 ugguCCAAGGUGGGGUCGUCCg || | :: ||||||| caacGGGGCAGUGGCAGCAGGu 2 19 288 309 [mm9:X:7507286-7507307:-] 0.6122 142 7 -21.53 -0.4235 MIMAT0001542 mmu-miR-449a 15185 Hdac6 uggUCGAUUGUUAUGUGACGGu | | | | |||||||| ---AUCCCAGACCACACUGCCu 2 20 1 19 [mm9:X:7507576-7507594:-] 0.6619 147 7 -18.55 -0.7394 MIMAT0001542 mmu-miR-449a 15185 Hdac6 uggucgauuguuauGUGACGGu ||||||| gaugugccccugccCACUGCCu 2 9 171 192 [mm9:X:7507403-7507424:-] 0.6490 140 7 -14.47 -0.2641 MIMAT0003460 mmu-miR-449c 15185 Hdac6 ggucgaucguuacGUGACGGa ||||||| --aucccagaccaCACUGCCu 2 9 1 19 [mm9:X:7507576-7507594:-] 0.6619 140 7 -19.67 -0.7394 MIMAT0003460 mmu-miR-449c 15185 Hdac6 ggucgaucguuacGUGACGGa ||||||| augugccccugccCACUGCCu 2 9 172 192 [mm9:X:7507403-7507423:-] 0.6490 140 7 -17.65 -0.2595 MIMAT0004853 mmu-miR-874 15185 Hdac6 agccagGGAGCCCGGUCCCGUc || | || ||||||| cugaggCCACAGG-CAGGGCAg 2 17 29 49 [mm9:X:7507546-7507566:-] 0.5834 150 7 -24.61 -0.1021 MIMAT0005447 mmu-miR-449b 15185 Hdac6 cggucGAUUGUUGUGACGGa | :|| |||||||| -auccCAGACCACACUGCCu 2 16 1 19 [mm9:X:7507576-7507594:-] 0.6619 155 7 -22.56 -0.7431 MIMAT0005447 mmu-miR-449b 15185 Hdac6 cggucgauuguuGUGACGGa ||||||| ugugccccugccCACUGCCu 2 9 173 192 [mm9:X:7507403-7507422:-] 0.6490 140 7 -18.97 -0.2618

DNA & RNA Element - TRANSFAC Accession AS Description Species Entrez Pubmed Binding Info G045269 Hdac6 Mus musculus 15185 25516595 74 96 R66881; MOUSE$HDAC6_01; Binding factors: mmu-miR-26a-5p //919 0 R70167; MOUSE$HDAC6_02; Binding factors: FOXO3a