PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Itpa Arhgef7 15102471 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ywhae Arhgef7 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Arhgef7 Parvb 24035453 intact exp P Ywhab Arhgef7 20338996,16635246 biogrid,intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Pak1 Arhgef7 15102471 i2d,intact exp Cenpc Arhgef7 21274006 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ywhaz Arhgef7 16959763 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Git1 Arhgef7 16959763,19022416 biogrid,i2d,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G Egfr Arhgef7 16892055 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G Cblb Arhgef7 16892055 biogrid exp, ortho Arhgef7 Git2 15102471 i2d,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pxn Arhgef7 12153727,20308429 biogrid,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Lrrk2 Arhgef7 21048939 biogrid,intact exp, ortho GP G G G G G G G G G G G G G G G G G G Pak3 Arhgef7 9726964 biogrid exp, ortho P G G G G G G G G G G G Arhgef6 Arhgef7 16959763 intact exp, ortho Rasgrf1 Arhgef7 ortho G G G G G G G G G G G G G G G G Ywhag Arhgef7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Tgfbr2 Arhgef7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Arhgef7 Gsk3b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Smad4 Arhgef7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Scrib Arhgef7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Smad1 Arhgef7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Arhgef1 Arhgef7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Erbb2ip Arhgef7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Slc33a1 Arhgef7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Shank3 Arhgef7 ortho G G G G G G G G G G G G G G G G G G G G G G Mcm7 Arhgef7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ctnnb1 Arhgef7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Abr Arhgef7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G Arhgef7 Csnk1e ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Dvl2 Arhgef7 ortho G G G G G G G G G G G Arhgef7 Arhgef7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Rel Arhgef7 ortho G G G Cers2 Arhgef7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Arhgef7 Naa10 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Med4 Arhgef7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc42bpa Arhgef7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2r1a Arhgef7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Cd244 Arhgef7 ortho G G Vav1 Arhgef7 ortho G G G G Tubb4a Arhgef7 ortho P G G G G G G G G G G G G G G G G G Cask Arhgef7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G Ppm1e Arhgef7 ortho Lck Arhgef7 ortho G G G G G G G G G G G G Nsfl1c Arhgef7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Akt1 Arhgef7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Tiam1 Arhgef7 ortho G G G G G G G G G G G G G G G G G G G G G G G G Relb Arhgef7 ortho G G G G G G G G G G G G Arhgef7 Itsn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Was Arhgef7 ortho G G G G G G G Cbl Arhgef7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Srgap1 Arhgef7 ortho P G Nck2 Arhgef7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Arhgef7 Itsn2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Arhgef18 Arhgef7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Nck1 Arhgef7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Smad3 Arhgef7 ortho G G G G G G G G G G G G G G Dnmbp Arhgef7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Raf1 Arhgef7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Adam15 Arhgef7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sos1 Arhgef7 ortho P G G G G G G G G G Shank1 Arhgef7 ortho Nod2 Arhgef7 ortho Sec23ip Arhgef7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Kdm2a Arhgef7 ortho Protein Arhgef11, Rho guanine nucleotide exchange factor (GEF) 11 Arhgef7 ortho Lta Arhgef7 ortho G G Nkd1 Arhgef7 ortho G G G G G G Arhgef7 Mtor ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppm1f Arhgef7 ortho P Vav2 Arhgef7 ortho G Meox2 Arhgef7 ortho G G G G G G G G G Farp1 Arhgef7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Pak2 Arhgef7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Akap13 Arhgef7 ortho P Ccl5 Arhgef7 ortho G G G G G G G G G G G Trio Arhgef7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tubb3 Arhgef7 ortho P G G G G G G G G G G Arhgef7 Nckipsd ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Bcr Arhgef7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspb1 Arhgef7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Farp2 Arhgef7 ortho G G G G G G G Smad2 Arhgef7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Itch Arhgef7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ntrk1 Arhgef7 ortho Sh2d1a Arhgef7 ortho P G G Grb2 Arhgef7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Csnk1a1 Arhgef7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Gorasp1 Arhgef7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Arhgef5 Arhgef7 ortho GP G G G G G G G G G G G G G G G G G G G G G Arhgef16 Arhgef7 ortho P G G G G G G G G G G G G G G Rela Arhgef7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Axin1 Arhgef7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Shc1 Arhgef7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Stat6 Arhgef7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Mcf2l Arhgef7 ortho Ahr Arhgef7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Axin2 Arhgef7 ortho G G G G G G G G G G G G G G G G G G G G G G Arhgef7 Srf ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Blk Arhgef7 ortho G G G G Rac1 Arhgef7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Shank2 Arhgef7 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9ES28 anti bait coimmunoprecipitation 15182672 association C 3 Q9ES28 pull down 15182672 association C 3 Q9ES28 cosedimentation through density gradient 16635246 colocalization C 608 Q9ES28 Q68FF6 anti bait coimmunoprecipitation 16959763 physical association X 2 Q9ES28 Q9HBI1 anti bait coimmunoprecipitation 18325335 physical association X 2 Q9ES28 Q9HBI1 pull down 18325335 physical association X 2 Q9ES28 Q9HBI1 pull down 18325335 physical association X 2 Q9ES28 Q9HBI1 pull down 18325335 direct interaction X 2 Q9ES28 Q9HBI1 pull down 18325335 direct interaction X 2 Q9ES28 Q9HBI1 fluorescence microscopy 18325335 colocalization X 2 Q9ES28 Q9HBI1 anti bait coimmunoprecipitation 18325335 physical association X 2 Q9ES28 Q9HBI1 anti bait coimmunoprecipitation 18325335 physical association X 2 Q9ES28 Q9HBI1 anti bait coimmunoprecipitation 18325335 physical association X 2 Q9ES28 Q9HBI1 anti bait coimmunoprecipitation 18325335 physical association X 2 Q9ES28 Q8VI36 fluorescence microscopy 20308429 colocalization X 2 Q9ES28 Q9Z272 pull down 21295525 physical association X 2 Q9ES28 Q14161 pull down 21295525 physical association X 2 Q9ES28 Q9ES46 anti tag coimmunoprecipitation 24035453 physical association X 2 Q9ES28 Q9ES46 anti tag coimmunoprecipitation 24035453 physical association X 2 Q9ES28 tandem affinity purification 16959763 association C 59 Q9ES28 pull down 21295525 association C 3 Q9ES28 anti bait coimmunoprecipitation 20308429 association C 3 Q9ES28 anti bait coimmunoprecipitation 19022416 association C 14 Q9ES28 Q9JLQ2 two hybrid 15102471 physical association X 2 Q9ES28 Q9JLQ2 two hybrid 15102471 physical association X 2 Q9ES28 Q9JLQ2 two hybrid 15102471 physical association X 2 Q9ES28 Q9JLQ2 two hybrid 15102471 physical association X 2 Q9ES28 Q9JLQ2 two hybrid 15102471 physical association X 2 Q9ES28 O88643 two hybrid 15102471 physical association X 2 Q9ES28 Q9JLQ2 two hybrid 15102471 physical association X 2 Q9ES28 Q9D892 two hybrid 15102471 physical association X 2 Q9ES28 Q5S006 anti bait coimmunoprecipitation 21048939 physical association X 2 Q9ES28 pull down 21295525 association C 3 Q9ES28 anti bait coimmunoprecipitation 16959763 association C 3

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Lrrk2 Arhgef7 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 21048939 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0403(colocalization) (intact)|(biogrid) UniProt_172918|BIOGRID_322898 bait|bait prey|prey Itpa Arhgef7 MI:0018(two hybrid)|MI:0027(cosedimentation) 15102471,16615898 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0403(colocalization) (intact)|(intact) UniProt_163027|UniProt_167114 prey|neutral component bait|neutral component Ywhaz Arhgef7 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0029(cosedimentation through density gradient)|MI:0027(cosedimentation) 16615898,16635246,16959763 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0403(colocalization) (biogrid)|(biogrid)|(biogrid)|(intact)|(intact) BIOGRID_327508|BIOGRID_327505|BIOGRID_327354|UniProt_166352|UniProt_167114 bait|prey|bait|neutral component|neutral component prey|bait|prey|neutral component|neutral component Arhgef7 Parvb MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 24035453 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_176691|UniProt_176690 bait|prey prey|bait Pak3 Arhgef7 MI:0018(two hybrid)|MI:0027(cosedimentation) 16615898,9726964 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0403(colocalization) (biogrid)|(intact) BIOGRID_312126|UniProt_167114 bait|neutral component prey|neutral component Egfr Arhgef7 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16892055 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_321285|BIOGRID_321286 bait|prey prey|bait Cblb Arhgef7 MI:0004(affinity chromatography technology) 16892055 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_321284 bait prey Arhgef7 Git2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15102471 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(intact)|(intact) UniProt_162567|UniProt_162827|UniProt_164934|UniProt_164933|UniProt_164932|UniProt_164931 bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey Pxn Arhgef7 MI:0416(fluorescence microscopy)|MI:0004(affinity chromatography technology)|MI:0027(cosedimentation)|MI:0416(fluorescence microscopy) 12153727,16615898,20308429 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0915(physical association)|MI:0403(colocalization)|MI:0914(association) (intact)|(biogrid)|(intact)|(intact) UniProt_169985|BIOGRID_312074|UniProt_167114|UniProt_169980 neutral component|bait|neutral component|bait neutral component|prey|neutral component|prey Git1 Arhgef7 MI:0029(cosedimentation through density gradient)|MI:0004(affinity chromatography technology)|MI:0676(tandem affinity purification)|MI:0006(anti bait coimmunoprecipitation) 16635246,16959763,19022416 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association) (intact)|(biogrid)|(intact)|(intact) UniProt_166352|BIOGRID_327507|UniProt_166716|UniProt_168907 neutral component|prey|prey|bait neutral component|bait|bait|prey Ywhab Arhgef7 MI:0004(affinity chromatography technology)|MI:0029(cosedimentation through density gradient) 16635246,20338996 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0403(colocalization) (biogrid)|(intact) BIOGRID_316327|UniProt_166352 prey|neutral component bait|neutral component Pak1 Arhgef7 MI:0018(two hybrid)|MI:0027(cosedimentation) 15102471,16615898 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0403(colocalization) (intact)|(intact) UniProt_162818|UniProt_167114 prey|neutral component bait|neutral component

PPI - HINT Gene A Gene B PMID Method Quality PAK1 ARHGEF7 15102471 0018 LC YWHAE ARHGEF7 16615898 0027 LC PXN ARHGEF7 20308429,20308429 0006,0416 LC YWHAB ARHGEF7 16635246 0029 LC ITPA ARHGEF7 15102471 0018 LC ARHGEF7 ARHGEF7 16307729 0114 LC ARHGEF7 GIT2 15102471 0018 LC CENPC ARHGEF7 21274006 0096 LC YWHAZ ARHGEF7 16959763 0004 LC EGFR ARHGEF7 16892055 0004 LC CBLB ARHGEF7 16892055 0004 LC SHANK3 ARHGEF7 27507650 0004 LC LRRK2 ARHGEF7 21048939,21048939 0428,0006 LC PAK3 ARHGEF7 9726964 0004 LC GIT1 ARHGEF7 16959763,19022416,16959763 0004,0006,0006 LC ARHGEF6 ARHGEF7 16959763 0006 LC PXN ARHGEF7 12153727,20308429,20308429 0004,0006,0416 LC YWHAB ARHGEF7 20338996 0004 LC Q9EQR1 ARHGEF7 16892055 0004 LC ARHGEF7 PARVB 24035453 0007 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9ES28 P60953 ARHGEF7 CDC42 0.309 14505571 Q9ES28 Q61036 ARHGEF7 PAK3 0.21 9726964 Q9ES28 Q8K4I3 ARHGEF7 ARHGEF6 0.126 16959763 Q9ES28 P62259 ARHGEF7 YWHAE 0.081 16615898 Q9HBI1 Q9ES28 PARVB ARHGEF7 0.702 18325335 Q9HCE7 Q9ES28 SMURF1 ARHGEF7 0.126 15761153 Q9ES28 Q68FF6 ARHGEF7 GIT1 0.332 19022416,16959763 Q9ES28 O88643 ARHGEF7 PAK1 0.183 15102471 Q9Z272 Q9ES28 GIT1 ARHGEF7 0.376 21295525 Q9JLU4 Q9ES28 SHANK3 ARHGEF7 0.376 12626503 Q9ES28 Q5S006 ARHGEF7 LRRK2 0.309 21048939 Q9QX74 Q9ES28 SHANK2 ARHGEF7 0.507 12626503 Q9WV48 Q9ES28 SHANK1 ARHGEF7 0.507 12626503 Q9ES28 Q8VI36 ARHGEF7 PXN 0.21 12153727 Q9ES28 Q9CQV8 ARHGEF7 YWHAB 0.274 16635246,20338996 Q9ES28 Q9D892 ARHGEF7 ITPA 0.183 15102471 Q9ES28 P41227 ARHGEF7 NAA10 0.21 21295525 Q9ES28 P63101 ARHGEF7 YWHAZ 0.236 16959763 Q9ES28 Q01279 ARHGEF7 EGFR 0.376 16892055 Q9ES28 Q14161 ARHGEF7 GIT2 0.376 21295525 Q9ES46 Q9ES28 PARVB ARHGEF7 0.376 24035453 Q9JLQ2 Q9ES28 GIT2 ARHGEF7 0.332 15102471 Q9ES28 P84022 ARHGEF7 SMAD3 0.126 15761153 Q9ES28 P49452 ARHGEF7 CENPC 0.126 21274006 Q9ES28 Q13485 ARHGEF7 SMAD4 0.126 15761153 Q9ES28 P63104 ARHGEF7 YWHAZ 0.126 16959763 Q9ES28 Q15796 ARHGEF7 SMAD2 0.126 15761153 Q9ES28 Q3TTA7 ARHGEF7 CBLB 0.21 16892055 Q9ES28 Q4ACU6 ARHGEF7 SHANK3 0.126 27507650