PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Sox2 Wwp2 25042802 biogrid exp G G G G G G G G G G G Polr2a Wwp2 17526739 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smarcc1 Wwp2 17526739,24365151 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gsc Wwp2 21170031 biogrid exp Ube2l3 Wwp2 21170031 biogrid exp, ortho P Egr2 Wwp2 19651900 biogrid exp, ortho G G G G G G G G G Pou5f1 Wwp2 15047715 biogrid exp, ortho Ntrk1 Wwp2 ortho Wbp2 Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2e1 Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Arrdc3 Wwp2 ortho Nxf1 Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smad1 Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tubgcp2 Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Amot Wwp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Dido1 Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dgcr2 Wwp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Traf4 Wwp2 ortho G G G G G G G G G G G G G G G G G G Wwp2 Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pdlim7 Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Wwp2 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mknk2 Wwp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smad7 Wwp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Cpsf7 Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G S1pr1 Wwp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cpsf6 Wwp2 ortho P Sftpc Wwp2 ortho G G G G G G G G Ubc Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Arrdc1 Wwp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tp53bp2 Wwp2 ortho P Rusc1 Wwp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smad2 Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wwp2 Scnn1b ortho G G G G G G G G G Wwp2 Psmd10 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Amotl1 Wwp2 ortho Tmem255a Wwp2 ortho Ankrd44 Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Dvl2 Wwp2 ortho G G G G G G G G G G G G Fbxl15 Wwp2 ortho G G G G G G G G G G G G G G G G G G G Arrestin domain containing 4, Protein Arrdc4 Wwp2 ortho G G G G G G G G G G G G G G G G G G G G G G Ubp1 Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wwp2 Scn5a ortho G G G G G G G Scamp3 Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fam168a Wwp2 ortho Eif3a Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lgals9 Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Adarb1 Wwp2 ortho G G G G G G Vasp Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Fbxl18 Wwp2 ortho Scnn1a Wwp2 ortho G G G G G G G G G G G G G G G G G G Smad3 Wwp2 ortho G G G G G G G G G G G G G G G Cdc34 Wwp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d3 Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp7 Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d2 Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Paip1 Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vps11 Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sort1 Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tgfbr1 Wwp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atn1 Wwp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G Notch3 Wwp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Il6ra Wwp2 ortho G G G G G G G G G G G G G G G Ezh2 Wwp2 ortho G G G G G G G G G G G G G G G G G G G G G G Fam189a2 Wwp2 ortho Wwp2 Clcn5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cep131 Wwp2 ortho G G G G G G G G Ndfip2 Wwp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2j2 Wwp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ndfip1 Wwp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mov10 Wwp2 ortho G G G G G G G G G G G G G G G G G G G Ube2e3 Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wipf1 Wwp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G Wwp2 Scnn1g ortho G G Tmem132a Wwp2 ortho G G G G G G G G G G G G G G G G G G G G G G Ptch1 Wwp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vps37c Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2k Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxo11 Wwp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ldlrad4 Wwp2 ortho G Dvl3 Wwp2 ortho Smad6 Wwp2 ortho G G G G G G G G G G G G G G G G G G G Hnrnpul1 Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ptpn14 Wwp2 ortho Pabpc1 Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tfap2a Wwp2 ortho G G G G G G Pten Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Sec24d, Sec24 related gene family, member D (S. cerevisiae) Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Wwp2 Cul1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2g1 Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Rasa1 Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atp6ap2 Wwp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Il2rg Wwp2 ortho G G G G G G G G G G G G G G G G G G G G Tnk2 Wwp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wbp1 Wwp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dag1 Wwp2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q02591 Q9DBH0 affinity chromatography technology 21170031 physical association X 2 Q02591 Q9DBH0 pull down 21170031 direct interaction X 2 Q02591 Q9DBH0 enzymatic study 21170031 direct interaction X 2 Q00915 Q9DBH0 affinity chromatography technology 17526739 physical association X 2 Q00915 Q9DBH0 enzymatic study 17526739 direct interaction X 2 O15105-2 Q9DBH0 affinity chromatography technology 15761153 physical association X 2 P08152 Q9DBH0 affinity chromatography technology 19651900 physical association X 2 Q9DBH0 P48432 affinity chromatography technology 25042802 physical association X 2 Q9DBH0 P0CG50 affinity chromatography technology 21170031 physical association X 2 Q9DBH0 P36897 affinity chromatography technology 15761153 physical association X 2 Q9DBH0 pull down 15047715 direct interaction X 2 Q9DBH0 P97496 affinity chromatography technology 24365151 physical association X 2 Q9DBH0 P97496 pull down 24365151 direct interaction X 2 Q9DBH0 P97496 affinity chromatography technology 24365151 physical association X 2 Q9DBH0 P97496 affinity chromatography technology 24365151 physical association X 2 Q9DBH0 P97496 enzymatic study 24365151 direct interaction X 2 Q9DBH0 Q15796-2 affinity chromatography technology 15761153 physical association X 2 Q9DBH0 affinity chromatography technology 15761153 physical association X 2

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9DBH0 O15105 WWP2 SMAD7 0.126 15761153 Q9DBH0 Q8NEA6 WWP2 GLIS3 0.309 26147758 Q9DBH0 P08775 WWP2 POLR2A 0.74 17526739 Q9DBH0 P36897 WWP2 TGFBR1 0.126 15761153 Q9DBH0 P08152 WWP2 EGR2 0.21 19651900 Q9DBH0 P20263 WWP2 POU5F1 0.309 15047715 Q9DBH0 P48432 WWP2 SOX2 0.21 25042802 Q9DBH0 P68037 WWP2 UBE2L3 0.309 21170031 Q9DBH0 Q15637 WWP2 SF1 0.126 26420826 Q9DBH0 P84022 WWP2 SMAD3 0.126 15761153 Q9DBH0 P97496 WWP2 SMARCC1 0.794 17526739,24365151 Q9DBH0 Q02591 WWP2 GSC 0.623 21170031 Q9DBH0 Q15796 WWP2 SMAD2 0.126 15761153