PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Usp2 Arntl 23213472,21966515 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Csnk1e 21966515 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Nedd4 21478478 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Nr3c2 23548632 biogrid exp Per2 Usp2 23213472 biogrid exp G G G G G G G G G G G G G G G G G G G G Usp2 Cry2 23213472 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Usp2 14686789 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G Per1 Usp2 23213472,21966515 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Ubc 21966515 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Cry1 23213472,21966515 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Bap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Nfkb2 ortho G G G G G G G G G G G Usp2 Egfr ortho G G G G G G G G G G G G G G G G G G Usp2 Vps52 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Lhx4 ortho G Usp2 Aurka ortho G G G G G G G G G G Usp2 Ndel1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Homer3 ortho G G G G G G G G G Usp2 Znf598 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Cacna2d2 ortho G G G G G G G G G G Usp2 Ubox5 ortho G G G G G G G G G G G G G G G G G Usp2 Golga2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Trim8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Tnfrsf1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Dtx3 ortho G G G G G G G G G G G G G G G G G G G G G G Usp2 Brca1 ortho G G G G G G G G G Usp2 Mnat1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Rrp15 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Malt1 ortho Usp2 Prkaa1 ortho Usp2 Rnf166 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G Usp2 Pcgf6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Pik3r3 ortho Usp2 Ccdc85b ortho Usp2 App ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Kifc3 Usp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Begain ortho Usp2 Nefl ortho G G G G G G G G Usp2 Hook1 ortho Usp2 Ccdc57 ortho Usp2 Traf6 ortho G G G G G G G G G G G G G G G G G Usp2 Tbk1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Mtus2 ortho Usp2 Trim23 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Mov10 ortho G G G G G G G G G G G G G G G G Protein Lonrf1 Usp2 ortho Usp2 Kcnq1 ortho G G G G G G G G G G G G G G G Usp2 Rnf126 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Krt40 ortho Usp2 Rnf144b ortho G Usp2 Pcna ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Ccdc136 ortho G G G G G G G G G G G G G G G Usp2 Lzts2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Bend5 ortho Ikbkg Usp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Rbck1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Trim35 ortho G G G G G G G G G G G G G G G G G G G Usp2 Ccdc36 ortho Usp2 Tradd ortho G G G G G G G G G G G G G G G G G G G G G Usp2 Hace1 ortho G G G G G G G G G G Usp2 Rad18 ortho G G G Usp2 Ube2s ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Fasn ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Scnn1g ortho G G Usp2 Trim9 ortho Usp2 Erbb2 ortho G G G G G G G G G G G G Usp2 Casp8 ortho G G G G G G G G G G G G G G G G G G G G Usp2 Krt15 ortho G G G G G G Usp2 Card11 ortho Usp2 Usp21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Ripk1 ortho G G G G G G G G G G G G G G G G G G G G G Usp2 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Traf2 ortho G G G G G G G G G G G G G G G G G G G G G Usp2 Scnn1a ortho G G G G G G G G G G G G G G G G Usp2 Trim39 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Hook2 ortho G G G G G G G G G G G G G G Usp2 Ccnd1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Mdm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Usp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Map3k2 ortho Usp2 Traip ortho G G G G G Usp2 Ccna1 ortho G Usp2 Trim54 ortho G G G G G G G Usp2 Nxf1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Lnx2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Cblc ortho G G G G G G G G G G G G Usp2 Trim27 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Lonp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Usp2 Pnma1 ortho Usp2 Scnn1b ortho G G G G G G G G G Usp2 Trim46 ortho G G G G G G G G G G G Usp2 Trim63 ortho Usp2 Lrsam1 ortho

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Usp2 Csnk1e MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21966515 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_321886|BIOGRID_321896 bait|prey prey|bait Per1 Usp2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21966515,23213472 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_321891|BIOGRID_325042|BIOGRID_325041|BIOGRID_325036 bait|bait|prey|prey prey|prey|bait|bait Usp2 Nedd4 MI:0004(affinity chromatography technology) 21478478 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_316151 bait prey Usp2 Ubc MI:0004(affinity chromatography technology) 21966515 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_321880 prey bait Usp2 Cry1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21966515,23213472 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_321884|BIOGRID_325038|BIOGRID_321893 bait|bait|prey prey|prey|bait Per2 Usp2 MI:0004(affinity chromatography technology) 23213472 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_325037 prey bait Usp2 Nr3c2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23548632 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_328888|BIOGRID_328889 bait|prey prey|bait Usp2 Arntl MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21966515,23213472 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_321883|BIOGRID_321885|BIOGRID_325040 prey|bait|bait bait|prey|prey Usp2 Cry2 MI:0004(affinity chromatography technology) 23213472 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_325039 bait prey

PPI - HINT Gene A Gene B PMID Method Quality NR3C2 USP2 23548632 0004 LC PER1 USP2 21966515,23213472,23213472 0004,0004,0096 LC USP2 USP2 14686789 0096 LC USP2 UBC 21966515 0004 LC USP2 NEDD4 21478478 0096 LC USP2 CRY1 21966515,23213472 0004,0004 LC USP2 Q8C8R0 23213472 0004 LC USP2 CSNK1E 21966515 0004 LC USP2 CRY2 23213472 0004 LC USP2 ARNTL 21966515,23213472 0004,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID O88623 O54943 USP2 PER2 0.376 23213472 Q9JMK2 O88623 CSNK1E USP2 0.376 21966515 P0CG50 O88623 UBC USP2 0.21 21966515 O88623 O75604 USP2 USP2 0.309 14686789 O88623 O88623 USP2 USP2 0.332 14686789 P46934 O88623 NEDD4 USP2 0.21 21478478 P46935 O88623 NEDD4 USP2 0.309 21478478 Q9WTL8 O88623 ARNTL USP2 0.61 21966515,23213472 P97784 O88623 CRY1 USP2 0.61 21966515,23213472 O88623 O35973 USP2 PER1 0.765 21966515,23213472 Q9R194 O88623 CRY2 USP2 0.376 23213472