PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Gnb5 Ywhab 16635246 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G Ywhae Gnb5 16615898 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Ppp1r9b 18439408 intact exp Gng4 Gnb5 8636150 dip exp, ortho G G G G G G G Gnb5 Rgs7bp 15897264 biogrid exp, ortho Rgs9 Gnb5 18204463 dip exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Hspa8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Rgs7 Gnb5 ortho G G G G G G G G G G Cct8 Gnb5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmc5 Gnb5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Ahsa1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Mlf2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Aldh1b1 ortho G G G G G G G G G Gria1 Gnb5 ortho G G G G G G G G Gnb5 Cdc42bpa ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Cct4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Pdcl3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Cct6b ortho G Cad Gnb5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Psmd2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Cct2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Cct6a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Mvd ortho G G G G G G G G G G G G G G G G G G G G G Gnb5 Gnb5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Pfdn5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Nr6a1 ortho G G G G App Gnb5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Mtor ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Pmm2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspa9 Gnb5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Psd ortho G G G G G G G G G G G G Gnb5 Xpr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Anxa7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Rgs6 ortho Gnb5 Csnk2b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Mlf1 ortho G G G G G G G G G G G Gnb5 Rhoa ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Pdcl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd4 Gnb5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G E2f2 Gnb5 ortho Gnb5 Isyna1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd3 Gnb5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Usp38 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Smpx ortho G G G G G G G G G G G G G G G Gnb5 Yeats4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Stip1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdkn1a Gnb5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Cops5 Gnb5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Aarsd1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Gnb5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Gng2 ortho G G G G G G G G G G G G G Gpi Gnb5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Nedd4l ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Rgs11 ortho G G G G G G G G G G G G G G G G Pfdn2 Gnb5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Cct3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Hspd1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Cct5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Eif2s3y ortho G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Rpa1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Skiv2l2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Actg1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Gng13 ortho G G G G G G G Gnb5 Elavl1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Zdhhc17 ortho Tsc22d1 Gnb5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Hsp90ab1 Gnb5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Olfm2 ortho Adrb2 Gnb5 ortho G G G G G G G G Gnb5 Mapk3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Nudc Gnb5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ahcy Gnb5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Atic ortho Shmt1 Gnb5 ortho G G G G G G G G G G G G G G G G G Psmc2 Gnb5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Dnaja2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Actr2 Gnb5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Mcm2 ortho G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Gngt1 ortho G Atp6v1b2 Gnb5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Dnajc7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Tcp1 Gnb5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Cct7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnai2 Gnb5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Gfpt2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Gng7 ortho Gnb5 Gng3 ortho G G G G G G G G G G G G G G Gnb5 Eprs ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb5 Mtap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Gng4 Gnb5 MI:0018(two hybrid) 8636150 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) MI:0465(dip) DIP_118 - - Rgs9 Gnb5 MI:0114(x-ray crystallography) 18204463 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) MI:0465(dip) DIP_631 - - Gnb5 Rgs7bp MI:0004(affinity chromatography technology) 15897264 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_327904 prey bait Gnb5 Gnb5 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 8636150 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|MI:0465(dip)|MI:0465(dip)|MI:0465(dip) DIP_122|DIP_120|DIP_111|DIP_113 -|-|-|- -|-|-|- Gnb5 Ppp1r9b MI:0006(anti bait coimmunoprecipitation)|MI:0029(cosedimentation through density gradient) 16635246,18439408 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0403(colocalization) (intact)|(intact) UniProt_167968|UniProt_166352 prey|neutral component bait|neutral component

PPI - HINT Gene A Gene B PMID Method Quality RGS9 GNB5 18204463 0114 LC GNG4 GNB5 8636150 0018 LC YWHAE GNB5 16615898 0027 LC GNB5 YWHAB 16635246 0029 LC GNB5 PPP1R9B 18439408 0006 LC GNB5 RGS7BP 15897264 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P62881 P62259 GNB5 YWHAE 0.081 16615898 Q8BQP9 P62881 RGS7BP GNB5 0.21 15897264 Q9CQV8 P62881 YWHAB GNB5 0.081 16635246 P63212 P62881 GNG2 GNB5 0.033 8636150 P63211 P62881 GNGT1 GNB5 0.033 8636150 P62881 P50153 GNB5 GNG4 0.033 8636150 P62881 P30671 GNB5 GNG7 0.033 8636150 P62881 O54828 GNB5 RGS9 0.309 18204463 P63214 P62881 GNG3 GNB5 0.033 8636150 P63217 P62881 GNG5 GNB5 0.033 8636150