PTM - CPLM Gene Name UniProt ID Type Position Code Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a P46935 Acetylation 529 K Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a P46935 Acetylation 734 K Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a P46935 Acetylation 130 K Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a P46935 Ubiquitination 93 K Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a P46935 Ubiquitination 130 K Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a P46935 Ubiquitination 186 K Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a P46935 Ubiquitination 206 K Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a P46935 Ubiquitination 278 K Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a P46935 Ubiquitination 429 K Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a P46935 Ubiquitination 453 K Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a P46935 Ubiquitination 484 K Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a P46935 Ubiquitination 83 K Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a P46935 Ubiquitination 92 K

PTM - dbPAF Gene Name UniProt ID Position Type Species Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a P46935 10 S Mus musculus(Mouse) Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a P46935 16 S Mus musculus(Mouse) Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a P46935 2 S Mus musculus(Mouse) Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a P46935 215 S Mus musculus(Mouse) Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a P46935 249 S Mus musculus(Mouse) Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a P46935 281 S Mus musculus(Mouse) Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a P46935 287 T Mus musculus(Mouse) Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a P46935 3 S Mus musculus(Mouse) Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a P46935 309 S Mus musculus(Mouse) Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a P46935 320 S Mus musculus(Mouse) Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a P46935 34 S Mus musculus(Mouse) Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a P46935 37 S Mus musculus(Mouse) Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a P46935 375 T Mus musculus(Mouse) Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a P46935 380 S Mus musculus(Mouse) Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a P46935 381 S Mus musculus(Mouse) Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a P46935 456 S Mus musculus(Mouse) Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a P46935 470 T Mus musculus(Mouse) Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a P46935 591 Y Mus musculus(Mouse) Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a P46935 592 Y Mus musculus(Mouse) Nedd4; Kiaa0093; Nedd-4; Nedd4-1; Nedd4a P46935 663 S Mus musculus(Mouse)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA P46935 S16-p Phosphorylation ESEAPVLsEDEVWEF P46935 S215-p Phosphorylation TYLPKNGsEDENADQ P46935 S281-p Phosphorylation RTQWkRPsPDDDLtD P46935 T287-p Phosphorylation PsPDDDLtDEDNDDM P46935 S309-p Phosphorylation FTTRRQIsEDVDGPD P46935 S320-p Phosphorylation DGPDNREsPENWEIV P46935 T470-p Phosphorylation PPGWEERtHTDGRVF P46935 S663-p Phosphorylation ITLHDMEsVDSEYYS P46935 K83-ub Ubiquitination DTRVVRVkVIAGIGL P46935 K92-ub Ubiquitination IAGIGLAkkDILGAS P46935 K93-ub Ubiquitination AGIGLAkkDILGASD P46935 K121-ub Ubiquitination ILTSVQTkTIkkSLN P46935 K124-ub Ubiquitination SVQTkTIkkSLNPkW P46935 K125-ub Ubiquitination VQTkTIkkSLNPkWN P46935 K130-ub Ubiquitination IkkSLNPkWNEEILF P46935 K186-ub Ubiquitination MERPYTFkDFVLHPR P46935 K206-ub Ubiquitination VKGYLRLkMTYLPKN P46935 K278-ub Ubiquitination ESRRTQWkRPsPDDD P46935 K429-ub Ubiquitination YYVDHNSkTTTWSKP P46935 K453-ub Ubiquitination IPAHLRGkTDSNDLG P46935 K484-ub Ubiquitination FFINHNIkKTQWEDP P46935 K557-ub Ubiquitination VKRADLLkARLWIEF P46935 K568-ub Ubiquitination WIEFDGEkGLDYGGV

PTM - dbPTM UniProt ID Position Code Type Resources References P46935 287 T Phosphorylation Swiss-Prot 1010711 17242355;19131326;19367708 P46935 309 S Phosphorylation Swiss-Prot 1010711 16452087;19131326;19367708 P46935 309 S Phosphorylation PhosphoELM.10011 16452087 P46935 287 T Phosphorylation PhosphoELM.10011 17242355 P46935 215 S Phosphorylation Phosphositeplus.1010730 21659604 P46935 281 S Phosphorylation Phosphositeplus.1010730 19854140;21183079;21659605 P46935 309 S Phosphorylation Phosphositeplus.1010730 16452087;17242355;18779572;18846507;19367708;19854140;20139300;20415495;21183079;21659604;21659605 P46935 320 S Phosphorylation Phosphositeplus.1010730 20415495;21659604 P46935 287 T Phosphorylation Phosphositeplus.1010730 18846507;19367708;19655815;19854140;20139300;20415495;21183079;21659604;21659605 P46935 470 T Phosphorylation Phosphositeplus.1010730 17544362 P46935 281 S Phosphorylation SysPTM 1.1 18846507 P46935 309 S Phosphorylation SysPTM 1.1 18846507;17242355;18779572 P46935 287 T Phosphorylation SysPTM 1.1 17242355

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type P46935 287 T 17242355 HTP Phosphorylation P46935 309 S 16452087 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs P46935 287 Phosphothreonine 19131326;21183079 P46935 309 Phosphoserine 16452087;17242355;19131326;21183079

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type Nedd4 IPI00462445 S 309 TTRRQIpSEDVDGP phosphorylation Nedd4 IPI00462445 S 320 GPDNREpSPENWEI phosphorylation Nedd4 IPI00462445 T 287 SPDDDLpTDEDNDD phosphorylation

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID Nedd4 Mus musculus (Mouse) 429; 453; 484; 278; 206; 186; 130; 93; 92; 83 "429,YVDHNSKTTTWSK; 453,PAHLRGKTDSNDL; 484,FINHNIKKTQWED; 278,SRRTQWKRPSPDD; 206,KGYLRLKMTYLPK; 186,ERPYTFKDFVLHP; 130,KKSLNPKWNEEIL; 93,GIGLAKKDILGAS; 92,AGIGLAKKDILGA; 83,TRVVRVKVIAGIG" 429:22790023; 453:22790023; 484:22790023; 278:22790023; 206:22790023; 186:22790023; 130:22790023; 93:22790023; 92:22790023; 83:22790023